Experimental study on paratumoral injection of cisplatin-loaded microspheres for gastric cancer

Microspheres from glycolide-L-lactide copolymers incorporating cisplatin (CDDP-MS) were prepared to evaluate the sustained release and anticancer effect by paratumoral injection on the gastric cancer with regional lymphnode metastases induced by VX2 tumor in rabbits. In the first set of experiment,...

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Veröffentlicht in:	Kobe journal of the medical sciences 1999-10, Vol.45 (5), p.229-243
Hauptverfasser:	Narita, K, Ikuta, H, Hamabe, Y, Kuroda, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Biological Availability Cisplatin - administration & dosage Cisplatin - pharmacokinetics Disease Models, Animal Female Injections, Intralesional Injections, Intravenous Microspheres Neoplasm Transplantation Probability Rabbits Random Allocation Reference Values Sensitivity and Specificity Stomach Neoplasms - drug therapy
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