Alcohol, dementia and cognitive decline in the elderly: a systematic review
Background: dementia and cognitive decline have been linked to cardiovascular risk. Alcohol has known negative effects in large quantities but may be protective for the cardiovascular system in smaller amounts. Effect of alcohol intake may be greater in the elderly and may impact on cognition. Metho...
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| Veröffentlicht in: | Age and ageing 2008-09, Vol.37 (5), p.505-512 |
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| creator | Peters, Ruth Peters, Jean Warner, James Beckett, Nigel Bulpitt, Christopher |
| description | Background: dementia and cognitive decline have been linked to cardiovascular risk. Alcohol has known negative effects in large quantities but may be protective for the cardiovascular system in smaller amounts. Effect of alcohol intake may be greater in the elderly and may impact on cognition. Methods: to evaluate the evidence for any relationship between incident cognitive decline or dementia in the elderly and alcohol consumption, a systematic review and meta-analyses were carried out. Criteria for inclusion were longitudinal studies of subjects aged ≥65, with primary outcomes of incident dementia/cognitive decline. Results: 23 studies were identified (20 epidemiological cohort, three retrospective matched case-control nested in a cohort). Meta-analyses suggest that small amounts of alcohol may be protective against dementia (random effects model, risk ratio [RR] 0.63; 95% CI 0.53–0.75) and Alzheimer's disease (RR 0.57; 0.44–0.74) but not for vascular dementia (RR 0.82; 0.50–1.35) or cognitive decline (RR 0.89; 0.67–1.17) However, studies varied, with differing lengths of follow up, measurement of alcohol intake, inclusion of true abstainers and assessment of potential confounders. Conclusions: because of the heterogeneity in the data these findings should be interpreted with caution. However, there is some evidence to suggest that limited alcohol intake in earlier adult life may be protective against incident dementia later. |
| doi_str_mv | 10.1093/ageing/afn095 |
| format | Article |
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Alcohol has known negative effects in large quantities but may be protective for the cardiovascular system in smaller amounts. Effect of alcohol intake may be greater in the elderly and may impact on cognition. Methods: to evaluate the evidence for any relationship between incident cognitive decline or dementia in the elderly and alcohol consumption, a systematic review and meta-analyses were carried out. Criteria for inclusion were longitudinal studies of subjects aged ≥65, with primary outcomes of incident dementia/cognitive decline. Results: 23 studies were identified (20 epidemiological cohort, three retrospective matched case-control nested in a cohort). Meta-analyses suggest that small amounts of alcohol may be protective against dementia (random effects model, risk ratio [RR] 0.63; 95% CI 0.53–0.75) and Alzheimer's disease (RR 0.57; 0.44–0.74) but not for vascular dementia (RR 0.82; 0.50–1.35) or cognitive decline (RR 0.89; 0.67–1.17) However, studies varied, with differing lengths of follow up, measurement of alcohol intake, inclusion of true abstainers and assessment of potential confounders. Conclusions: because of the heterogeneity in the data these findings should be interpreted with caution. However, there is some evidence to suggest that limited alcohol intake in earlier adult life may be protective against incident dementia later.</description><identifier>ISSN: 0002-0729</identifier><identifier>EISSN: 1468-2834</identifier><identifier>DOI: 10.1093/ageing/afn095</identifier><identifier>PMID: 18487267</identifier><identifier>CODEN: AANGAH</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Age Factors ; Aged ; Ageing ; Aging ; alcohol ; Alcohol consumption ; Alcohol Drinking - adverse effects ; Alcohol Drinking - epidemiology ; Alcohol use ; Alzheimer's disease ; Cardiovascular disease ; Cognition - drug effects ; Cognition Disorders - epidemiology ; Cognition Disorders - etiology ; Cognition Disorders - prevention & control ; cognitive decline ; Cognitive impairment ; Dementia ; Dementia - epidemiology ; Dementia - etiology ; Dementia - prevention & control ; Dose-Response Relationship, Drug ; Drinking (Alcoholic beverages) ; Drinking of alcoholic beverages ; Elderly ; Elderly people ; Evidence-Based Medicine ; Female ; Humans ; Incidence ; Male ; Meta-analysis ; Middle Aged ; Odds Ratio ; Older people ; Physiological aspects ; Psychological aspects ; Risk Assessment ; Risk factors</subject><ispartof>Age and ageing, 2008-09, Vol.37 (5), p.505-512</ispartof><rights>Copyright © The Author 2008. Published by Oxford University Press on behalf of the British Geriatrics Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-dc7bae2ab4edf2a151c1c4a7d38ebbf2bd2217b297a2ddeb87563ce08a6d7ac33</citedby><cites>FETCH-LOGICAL-c495t-dc7bae2ab4edf2a151c1c4a7d38ebbf2bd2217b297a2ddeb87563ce08a6d7ac33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906,30980,30981</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18487267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peters, Ruth</creatorcontrib><creatorcontrib>Peters, Jean</creatorcontrib><creatorcontrib>Warner, James</creatorcontrib><creatorcontrib>Beckett, Nigel</creatorcontrib><creatorcontrib>Bulpitt, Christopher</creatorcontrib><title>Alcohol, dementia and cognitive decline in the elderly: a systematic review</title><title>Age and ageing</title><addtitle>Age Ageing</addtitle><description>Background: dementia and cognitive decline have been linked to cardiovascular risk. Alcohol has known negative effects in large quantities but may be protective for the cardiovascular system in smaller amounts. Effect of alcohol intake may be greater in the elderly and may impact on cognition. Methods: to evaluate the evidence for any relationship between incident cognitive decline or dementia in the elderly and alcohol consumption, a systematic review and meta-analyses were carried out. Criteria for inclusion were longitudinal studies of subjects aged ≥65, with primary outcomes of incident dementia/cognitive decline. Results: 23 studies were identified (20 epidemiological cohort, three retrospective matched case-control nested in a cohort). Meta-analyses suggest that small amounts of alcohol may be protective against dementia (random effects model, risk ratio [RR] 0.63; 95% CI 0.53–0.75) and Alzheimer's disease (RR 0.57; 0.44–0.74) but not for vascular dementia (RR 0.82; 0.50–1.35) or cognitive decline (RR 0.89; 0.67–1.17) However, studies varied, with differing lengths of follow up, measurement of alcohol intake, inclusion of true abstainers and assessment of potential confounders. Conclusions: because of the heterogeneity in the data these findings should be interpreted with caution. However, there is some evidence to suggest that limited alcohol intake in earlier adult life may be protective against incident dementia later.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Ageing</subject><subject>Aging</subject><subject>alcohol</subject><subject>Alcohol consumption</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Alcohol use</subject><subject>Alzheimer's disease</subject><subject>Cardiovascular disease</subject><subject>Cognition - drug effects</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - prevention & control</subject><subject>cognitive decline</subject><subject>Cognitive impairment</subject><subject>Dementia</subject><subject>Dementia - epidemiology</subject><subject>Dementia - etiology</subject><subject>Dementia - prevention & control</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drinking (Alcoholic beverages)</subject><subject>Drinking of alcoholic beverages</subject><subject>Elderly</subject><subject>Elderly people</subject><subject>Evidence-Based Medicine</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Older people</subject><subject>Physiological aspects</subject><subject>Psychological aspects</subject><subject>Risk Assessment</subject><subject>Risk factors</subject><issn>0002-0729</issn><issn>1468-2834</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkU1v1DAQQC0EotvCkSuKOHBqqO04tsNtWUEXUVSJLyEulmNPUhfHLna2dP89RrtiJS49jWbmaTQzD6FnBL8iuGvO9AgujGd6CLhrH6AFYVzWVDbsIVpgjGmNBe2O0HHO1yUlLaGP0RGRTArKxQJ9WHoTr6I_rSxMEGanKx1sZeIY3OxuoZSNdwEqF6r5CirwFpLfvq50lbd5hknPzlQJbh38foIeDdpneLqPJ-jru7dfVuv64vL8_Wp5URvWtXNtjeg1UN0zsAPVZSVDDNPCNhL6fqC9pZSInnZCU2uhl6LljQEsNbdCm6Y5QS93c29S_LWBPKvJZQPe6wBxkxXvmOCYdfeCraCtxA25F6SYCcEIL-CL_8DruEmhXKsoYYQKzGSB6h00ag_KBRPDDHezid7DCKr8YnWplkTylnDK8YE3KeacYFA3yU06bRXB6q9ktZOsdpIL_3y_xKafwB7ovdXDQFcM3f3r6_RTla5o1fr7D7X-vH7zafXxmzpv_gANVLLH</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Peters, Ruth</creator><creator>Peters, Jean</creator><creator>Warner, James</creator><creator>Beckett, Nigel</creator><creator>Bulpitt, Christopher</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20080901</creationdate><title>Alcohol, dementia and cognitive decline in the elderly: a systematic review</title><author>Peters, Ruth ; Peters, Jean ; Warner, James ; Beckett, Nigel ; Bulpitt, Christopher</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-dc7bae2ab4edf2a151c1c4a7d38ebbf2bd2217b297a2ddeb87563ce08a6d7ac33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Ageing</topic><topic>Aging</topic><topic>alcohol</topic><topic>Alcohol consumption</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Alcohol Drinking - epidemiology</topic><topic>Alcohol use</topic><topic>Alzheimer's disease</topic><topic>Cardiovascular disease</topic><topic>Cognition - drug effects</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - prevention & control</topic><topic>cognitive decline</topic><topic>Cognitive impairment</topic><topic>Dementia</topic><topic>Dementia - epidemiology</topic><topic>Dementia - etiology</topic><topic>Dementia - prevention & control</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drinking (Alcoholic beverages)</topic><topic>Drinking of alcoholic beverages</topic><topic>Elderly</topic><topic>Elderly people</topic><topic>Evidence-Based Medicine</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Older people</topic><topic>Physiological aspects</topic><topic>Psychological aspects</topic><topic>Risk Assessment</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peters, Ruth</creatorcontrib><creatorcontrib>Peters, Jean</creatorcontrib><creatorcontrib>Warner, James</creatorcontrib><creatorcontrib>Beckett, Nigel</creatorcontrib><creatorcontrib>Bulpitt, Christopher</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Age and ageing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peters, Ruth</au><au>Peters, Jean</au><au>Warner, James</au><au>Beckett, Nigel</au><au>Bulpitt, Christopher</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alcohol, dementia and cognitive decline in the elderly: a systematic review</atitle><jtitle>Age and ageing</jtitle><addtitle>Age Ageing</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>37</volume><issue>5</issue><spage>505</spage><epage>512</epage><pages>505-512</pages><issn>0002-0729</issn><eissn>1468-2834</eissn><coden>AANGAH</coden><abstract>Background: dementia and cognitive decline have been linked to cardiovascular risk. Alcohol has known negative effects in large quantities but may be protective for the cardiovascular system in smaller amounts. Effect of alcohol intake may be greater in the elderly and may impact on cognition. Methods: to evaluate the evidence for any relationship between incident cognitive decline or dementia in the elderly and alcohol consumption, a systematic review and meta-analyses were carried out. Criteria for inclusion were longitudinal studies of subjects aged ≥65, with primary outcomes of incident dementia/cognitive decline. Results: 23 studies were identified (20 epidemiological cohort, three retrospective matched case-control nested in a cohort). Meta-analyses suggest that small amounts of alcohol may be protective against dementia (random effects model, risk ratio [RR] 0.63; 95% CI 0.53–0.75) and Alzheimer's disease (RR 0.57; 0.44–0.74) but not for vascular dementia (RR 0.82; 0.50–1.35) or cognitive decline (RR 0.89; 0.67–1.17) However, studies varied, with differing lengths of follow up, measurement of alcohol intake, inclusion of true abstainers and assessment of potential confounders. Conclusions: because of the heterogeneity in the data these findings should be interpreted with caution. However, there is some evidence to suggest that limited alcohol intake in earlier adult life may be protective against incident dementia later.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>18487267</pmid><doi>10.1093/ageing/afn095</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Age and ageing, 2008-09, Vol.37 (5), p.505-512 |
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| source | MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA); Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Age Factors Aged Ageing Aging alcohol Alcohol consumption Alcohol Drinking - adverse effects Alcohol Drinking - epidemiology Alcohol use Alzheimer's disease Cardiovascular disease Cognition - drug effects Cognition Disorders - epidemiology Cognition Disorders - etiology Cognition Disorders - prevention & control cognitive decline Cognitive impairment Dementia Dementia - epidemiology Dementia - etiology Dementia - prevention & control Dose-Response Relationship, Drug Drinking (Alcoholic beverages) Drinking of alcoholic beverages Elderly Elderly people Evidence-Based Medicine Female Humans Incidence Male Meta-analysis Middle Aged Odds Ratio Older people Physiological aspects Psychological aspects Risk Assessment Risk factors |
| title | Alcohol, dementia and cognitive decline in the elderly: a systematic review |
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