Inherited thrombophilia screening in Greek women with recurrent fetal loss
The present study was designed to determine the prevalence of factor V Leiden (FVL), prothrombin gene G20210A (PTG) and methylenetetrahydrofolate reductase (MTHFR C677T) mutations in women from South-Western Greece with recurrent fetal loss (RFL) and negative personal thromboembolic history. 212 wom...
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| Veröffentlicht in: | Clinical and experimental obstetrics & gynecology 2008, Vol.35 (3), p.172-174 |
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| container_title | Clinical and experimental obstetrics & gynecology |
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| creator | Mougiou, A Androutsopoulos, G Karakantza, M Theodori, E Decavalas, G Zoumbos, N |
| description | The present study was designed to determine the prevalence of factor V Leiden (FVL), prothrombin gene G20210A (PTG) and methylenetetrahydrofolate reductase (MTHFR C677T) mutations in women from South-Western Greece with recurrent fetal loss (RFL) and negative personal thromboembolic history.
212 women with RFL and 181 women with at least two pregnancies with normal outcome and no history of pregnancy loss were investigated for the commonest thrombophilic mutations (FVL, PTG, MTHFR C677T). Comparisons between groups were performed by Pearson's chi-square test and odd ratios were calculated.
An abnormal genotype was detected in 49 women of the study group (23.1%) and in 41 women of the control group (22.6%).
Inherited thrombophilia screening is not indicated as an initial approach in Greek women with RFL and negative personal thromboembolic history. |
| format | Article |
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212 women with RFL and 181 women with at least two pregnancies with normal outcome and no history of pregnancy loss were investigated for the commonest thrombophilic mutations (FVL, PTG, MTHFR C677T). Comparisons between groups were performed by Pearson's chi-square test and odd ratios were calculated.
An abnormal genotype was detected in 49 women of the study group (23.1%) and in 41 women of the control group (22.6%).
Inherited thrombophilia screening is not indicated as an initial approach in Greek women with RFL and negative personal thromboembolic history.</description><identifier>ISSN: 0390-6663</identifier><identifier>PMID: 18754285</identifier><language>eng</language><publisher>Canada</publisher><subject>Abortion, Habitual - genetics ; Factor V - genetics ; Female ; Genetic Predisposition to Disease - epidemiology ; Genetic Predisposition to Disease - genetics ; Genetic Testing ; Greece - epidemiology ; Humans ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Pregnancy ; Prevalence ; Prothrombin - genetics ; Thrombophilia - epidemiology ; Thrombophilia - genetics</subject><ispartof>Clinical and experimental obstetrics & gynecology, 2008, Vol.35 (3), p.172-174</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18754285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mougiou, A</creatorcontrib><creatorcontrib>Androutsopoulos, G</creatorcontrib><creatorcontrib>Karakantza, M</creatorcontrib><creatorcontrib>Theodori, E</creatorcontrib><creatorcontrib>Decavalas, G</creatorcontrib><creatorcontrib>Zoumbos, N</creatorcontrib><title>Inherited thrombophilia screening in Greek women with recurrent fetal loss</title><title>Clinical and experimental obstetrics & gynecology</title><addtitle>Clin Exp Obstet Gynecol</addtitle><description>The present study was designed to determine the prevalence of factor V Leiden (FVL), prothrombin gene G20210A (PTG) and methylenetetrahydrofolate reductase (MTHFR C677T) mutations in women from South-Western Greece with recurrent fetal loss (RFL) and negative personal thromboembolic history.
212 women with RFL and 181 women with at least two pregnancies with normal outcome and no history of pregnancy loss were investigated for the commonest thrombophilic mutations (FVL, PTG, MTHFR C677T). Comparisons between groups were performed by Pearson's chi-square test and odd ratios were calculated.
An abnormal genotype was detected in 49 women of the study group (23.1%) and in 41 women of the control group (22.6%).
Inherited thrombophilia screening is not indicated as an initial approach in Greek women with RFL and negative personal thromboembolic history.</description><subject>Abortion, Habitual - genetics</subject><subject>Factor V - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetic Testing</subject><subject>Greece - epidemiology</subject><subject>Humans</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Pregnancy</subject><subject>Prevalence</subject><subject>Prothrombin - genetics</subject><subject>Thrombophilia - epidemiology</subject><subject>Thrombophilia - genetics</subject><issn>0390-6663</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j7FOwzAURT2AaCn8AvLEFsn2c-x4RBWUokosMEeO80IMiRNsRxV_TyXKdM9wdKR7QdYMDCuUUrAi1yl9MialVvyKrHilSymqck1e9qHH6DO2NPdxGptp7v3gLU0uIgYfPqgPdHfiL3qcRgz06HNPI7olRgyZdpjtQIcppRty2dkh4e15N-T96fFt-1wcXnf77cOhmAUzuQApHDIBsm14JTgaDVpwobg2TIKEBrQ04IzorISStbLpnFWSOV3aCoyDDbn_685x-l4w5Xr0yeEw2IDTkmpl5KnAzUm8O4tLM2Jbz9GPNv7U_-_hF0tDVIE</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Mougiou, A</creator><creator>Androutsopoulos, G</creator><creator>Karakantza, M</creator><creator>Theodori, E</creator><creator>Decavalas, G</creator><creator>Zoumbos, N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Inherited thrombophilia screening in Greek women with recurrent fetal loss</title><author>Mougiou, A ; Androutsopoulos, G ; Karakantza, M ; Theodori, E ; Decavalas, G ; Zoumbos, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-342ce0234db1821e9737212617904343b37493c92fa4350d4bfca640c75a839c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Abortion, Habitual - genetics</topic><topic>Factor V - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - epidemiology</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genetic Testing</topic><topic>Greece - epidemiology</topic><topic>Humans</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Pregnancy</topic><topic>Prevalence</topic><topic>Prothrombin - genetics</topic><topic>Thrombophilia - epidemiology</topic><topic>Thrombophilia - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mougiou, A</creatorcontrib><creatorcontrib>Androutsopoulos, G</creatorcontrib><creatorcontrib>Karakantza, M</creatorcontrib><creatorcontrib>Theodori, E</creatorcontrib><creatorcontrib>Decavalas, G</creatorcontrib><creatorcontrib>Zoumbos, N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental obstetrics & gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mougiou, A</au><au>Androutsopoulos, G</au><au>Karakantza, M</au><au>Theodori, E</au><au>Decavalas, G</au><au>Zoumbos, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inherited thrombophilia screening in Greek women with recurrent fetal loss</atitle><jtitle>Clinical and experimental obstetrics & gynecology</jtitle><addtitle>Clin Exp Obstet Gynecol</addtitle><date>2008</date><risdate>2008</risdate><volume>35</volume><issue>3</issue><spage>172</spage><epage>174</epage><pages>172-174</pages><issn>0390-6663</issn><abstract>The present study was designed to determine the prevalence of factor V Leiden (FVL), prothrombin gene G20210A (PTG) and methylenetetrahydrofolate reductase (MTHFR C677T) mutations in women from South-Western Greece with recurrent fetal loss (RFL) and negative personal thromboembolic history.
212 women with RFL and 181 women with at least two pregnancies with normal outcome and no history of pregnancy loss were investigated for the commonest thrombophilic mutations (FVL, PTG, MTHFR C677T). Comparisons between groups were performed by Pearson's chi-square test and odd ratios were calculated.
An abnormal genotype was detected in 49 women of the study group (23.1%) and in 41 women of the control group (22.6%).
Inherited thrombophilia screening is not indicated as an initial approach in Greek women with RFL and negative personal thromboembolic history.</abstract><cop>Canada</cop><pmid>18754285</pmid><tpages>3</tpages></addata></record> |
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| ispartof | Clinical and experimental obstetrics & gynecology, 2008, Vol.35 (3), p.172-174 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Abortion, Habitual - genetics Factor V - genetics Female Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Genetic Testing Greece - epidemiology Humans Methylenetetrahydrofolate Reductase (NADPH2) - genetics Pregnancy Prevalence Prothrombin - genetics Thrombophilia - epidemiology Thrombophilia - genetics |
| title | Inherited thrombophilia screening in Greek women with recurrent fetal loss |
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