HLA‐DQB102 Dose Effect on RIA Anti‐tissue Transglutaminase Autoantibody Levels and Clinicopathological Expressivity of Celiac Disease
ABSTRACT Objectives: Celiac disease is an autoimmune enteropathy caused by gluten ingestion in genetically susceptible individuals. Anti‐transglutaminase autoantibody (tTGAb) assay is useful to detect candidates undergoing intestinal biopsy. Our aim was to investigate whether the DQB1*02 allele coul...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2008-09, Vol.47 (3), p.288-292 |
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| container_title | Journal of pediatric gastroenterology and nutrition |
| container_volume | 47 |
| creator | Nenna, Raffaella Mora, Barbara Megiorni, Francesca Mazzilli, Maria Cristina Magliocca, Fabio Massimo Tiberti, Claudio Bonamico, Margherita |
| description | ABSTRACT
Objectives:
Celiac disease is an autoimmune enteropathy caused by gluten ingestion in genetically susceptible individuals. Anti‐transglutaminase autoantibody (tTGAb) assay is useful to detect candidates undergoing intestinal biopsy. Our aim was to investigate whether the DQB1*02 allele could influence tTGAb titers and the clinicopathological expressivity of the disease.
Methods:
A total of 124 patients with celiac disease, tested for RIA tTGAb at diagnosis, were typed for HLA‐DRB1, ‐DQA1, and ‐DQB1 genes and divided according to the number of DQB1*02 alleles: group 1, homozygous; group 2, heterozygous; group 3, negative.
Results:
The mean of tTGAb indexes was significantly higher in group 1 patients than in group 2 (P < 0.02) and group 3 patients (P < 0.01). Patients with at least 1 DQB1*02 allele showed more often a typical CD and diffuse histological lesions than did patients in the other groups.
Conclusions:
The study demonstrates that tTGAb titers are HLA‐DQB1*02 dose dependent, with significantly higher levels in homozygous individuals. Moreover, individuals with at least 1 HLA‐DQB1*02 allele tend to have a more expressed clinical and histological form of celiac disease. |
| doi_str_mv | 10.1097/MPG.0b013e3181615ca7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69474561</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69474561</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4805-ff1da2393bdc73b13e9d0e73bbef53d743c5715a46adf5c1f998f39f974839dd3</originalsourceid><addsrcrecordid>eNqNks1u1DAUhS0EokPhDRDyBnYpdhzH8YLFdGb6gwYoqKwtx7nuGDzxEDsts2PLjmfkSTA0ohIrVv7Rd-71PccIPaXkiBIpXr65OD0iLaEMGG1oTbnR4h6aUc7qomoIvY9mpBSiKCmtD9CjGD8RQkTFyUN0QBtRNrxkM_T9bD3_-e3H8v0xJSVehgh4ZS2YhEOPP5zP8bxPLgPJxTgCvhx0H6_8mPTW9TrD8zEFnZE2dHu8hmvwEeu-wwvvemfCTqdN8OHKGe3x6utugBjdtUt7HCxegHfa4KWLkEs9Rg-s9hGeTOsh-niyulycFet3p-eL-boweSpeWEs7XTLJ2s4I1ubxZUcg71qwnHWiYoYLynVV685yQ62UjWXSSlE1THYdO0QvbuvuhvBlhJjU1kUD3usewhhVLavsUk0zWN2CZggxDmDVbnBbPewVJep3BCpHoP6NIMueTfXHdgvdnWjyPAPPJ0DHbIvNlhoX_3IlqWnTMH7X_yb4BEP87McbGNQGtE8blcMknIq6KAlpiMyn4s9Vlr2aZM7D_r_erF5fvGXHJ6SS-ff8Agk8tOE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69474561</pqid></control><display><type>article</type><title>HLA‐DQB102 Dose Effect on RIA Anti‐tissue Transglutaminase Autoantibody Levels and Clinicopathological Expressivity of Celiac Disease</title><source>MEDLINE</source><source>Wiley Online Library</source><source>Journals@Ovid Complete</source><creator>Nenna, Raffaella ; Mora, Barbara ; Megiorni, Francesca ; Mazzilli, Maria Cristina ; Magliocca, Fabio Massimo ; Tiberti, Claudio ; Bonamico, Margherita</creator><creatorcontrib>Nenna, Raffaella ; Mora, Barbara ; Megiorni, Francesca ; Mazzilli, Maria Cristina ; Magliocca, Fabio Massimo ; Tiberti, Claudio ; Bonamico, Margherita</creatorcontrib><description>ABSTRACT
Objectives:
Celiac disease is an autoimmune enteropathy caused by gluten ingestion in genetically susceptible individuals. Anti‐transglutaminase autoantibody (tTGAb) assay is useful to detect candidates undergoing intestinal biopsy. Our aim was to investigate whether the DQB1*02 allele could influence tTGAb titers and the clinicopathological expressivity of the disease.
Methods:
A total of 124 patients with celiac disease, tested for RIA tTGAb at diagnosis, were typed for HLA‐DRB1, ‐DQA1, and ‐DQB1 genes and divided according to the number of DQB1*02 alleles: group 1, homozygous; group 2, heterozygous; group 3, negative.
Results:
The mean of tTGAb indexes was significantly higher in group 1 patients than in group 2 (P < 0.02) and group 3 patients (P < 0.01). Patients with at least 1 DQB1*02 allele showed more often a typical CD and diffuse histological lesions than did patients in the other groups.
Conclusions:
The study demonstrates that tTGAb titers are HLA‐DQB1*02 dose dependent, with significantly higher levels in homozygous individuals. Moreover, individuals with at least 1 HLA‐DQB1*02 allele tend to have a more expressed clinical and histological form of celiac disease.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1097/MPG.0b013e3181615ca7</identifier><identifier>PMID: 18728523</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adolescent ; Adult ; Alleles ; Anti‐transglutaminase autoantibodies ; Autoantibodies - blood ; Biological and medical sciences ; Celiac disease ; Celiac Disease - genetics ; Celiac Disease - immunology ; Celiac Disease - pathology ; Child ; Child, Preschool ; Clinical data ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology. Liver. Pancreas. Abdomen ; Genotype ; Histology ; HLA ; HLA-DQ Antigens - genetics ; HLA-DQ beta-Chains ; Humans ; Infant ; Male ; Medical sciences ; Other diseases. Semiology ; Radioimmunoassay ; Risk Factors ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Transglutaminases - immunology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Young Adult</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 2008-09, Vol.47 (3), p.288-292</ispartof><rights>2008 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>2008 Lippincott Williams & Wilkins, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4805-ff1da2393bdc73b13e9d0e73bbef53d743c5715a46adf5c1f998f39f974839dd3</citedby><cites>FETCH-LOGICAL-c4805-ff1da2393bdc73b13e9d0e73bbef53d743c5715a46adf5c1f998f39f974839dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2FMPG.0b013e3181615ca7$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2FMPG.0b013e3181615ca7$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20618835$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18728523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nenna, Raffaella</creatorcontrib><creatorcontrib>Mora, Barbara</creatorcontrib><creatorcontrib>Megiorni, Francesca</creatorcontrib><creatorcontrib>Mazzilli, Maria Cristina</creatorcontrib><creatorcontrib>Magliocca, Fabio Massimo</creatorcontrib><creatorcontrib>Tiberti, Claudio</creatorcontrib><creatorcontrib>Bonamico, Margherita</creatorcontrib><title>HLA‐DQB102 Dose Effect on RIA Anti‐tissue Transglutaminase Autoantibody Levels and Clinicopathological Expressivity of Celiac Disease</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>ABSTRACT
Objectives:
Celiac disease is an autoimmune enteropathy caused by gluten ingestion in genetically susceptible individuals. Anti‐transglutaminase autoantibody (tTGAb) assay is useful to detect candidates undergoing intestinal biopsy. Our aim was to investigate whether the DQB1*02 allele could influence tTGAb titers and the clinicopathological expressivity of the disease.
Methods:
A total of 124 patients with celiac disease, tested for RIA tTGAb at diagnosis, were typed for HLA‐DRB1, ‐DQA1, and ‐DQB1 genes and divided according to the number of DQB1*02 alleles: group 1, homozygous; group 2, heterozygous; group 3, negative.
Results:
The mean of tTGAb indexes was significantly higher in group 1 patients than in group 2 (P < 0.02) and group 3 patients (P < 0.01). Patients with at least 1 DQB1*02 allele showed more often a typical CD and diffuse histological lesions than did patients in the other groups.
Conclusions:
The study demonstrates that tTGAb titers are HLA‐DQB1*02 dose dependent, with significantly higher levels in homozygous individuals. Moreover, individuals with at least 1 HLA‐DQB1*02 allele tend to have a more expressed clinical and histological form of celiac disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alleles</subject><subject>Anti‐transglutaminase autoantibodies</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Celiac disease</subject><subject>Celiac Disease - genetics</subject><subject>Celiac Disease - immunology</subject><subject>Celiac Disease - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical data</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genotype</subject><subject>Histology</subject><subject>HLA</subject><subject>HLA-DQ Antigens - genetics</subject><subject>HLA-DQ beta-Chains</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Radioimmunoassay</subject><subject>Risk Factors</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Transglutaminases - immunology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Young Adult</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1u1DAUhS0EokPhDRDyBnYpdhzH8YLFdGb6gwYoqKwtx7nuGDzxEDsts2PLjmfkSTA0ohIrVv7Rd-71PccIPaXkiBIpXr65OD0iLaEMGG1oTbnR4h6aUc7qomoIvY9mpBSiKCmtD9CjGD8RQkTFyUN0QBtRNrxkM_T9bD3_-e3H8v0xJSVehgh4ZS2YhEOPP5zP8bxPLgPJxTgCvhx0H6_8mPTW9TrD8zEFnZE2dHu8hmvwEeu-wwvvemfCTqdN8OHKGe3x6utugBjdtUt7HCxegHfa4KWLkEs9Rg-s9hGeTOsh-niyulycFet3p-eL-boweSpeWEs7XTLJ2s4I1ubxZUcg71qwnHWiYoYLynVV685yQ62UjWXSSlE1THYdO0QvbuvuhvBlhJjU1kUD3usewhhVLavsUk0zWN2CZggxDmDVbnBbPewVJep3BCpHoP6NIMueTfXHdgvdnWjyPAPPJ0DHbIvNlhoX_3IlqWnTMH7X_yb4BEP87McbGNQGtE8blcMknIq6KAlpiMyn4s9Vlr2aZM7D_r_erF5fvGXHJ6SS-ff8Agk8tOE</recordid><startdate>200809</startdate><enddate>200809</enddate><creator>Nenna, Raffaella</creator><creator>Mora, Barbara</creator><creator>Megiorni, Francesca</creator><creator>Mazzilli, Maria Cristina</creator><creator>Magliocca, Fabio Massimo</creator><creator>Tiberti, Claudio</creator><creator>Bonamico, Margherita</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200809</creationdate><title>HLA‐DQB102 Dose Effect on RIA Anti‐tissue Transglutaminase Autoantibody Levels and Clinicopathological Expressivity of Celiac Disease</title><author>Nenna, Raffaella ; Mora, Barbara ; Megiorni, Francesca ; Mazzilli, Maria Cristina ; Magliocca, Fabio Massimo ; Tiberti, Claudio ; Bonamico, Margherita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4805-ff1da2393bdc73b13e9d0e73bbef53d743c5715a46adf5c1f998f39f974839dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alleles</topic><topic>Anti‐transglutaminase autoantibodies</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Celiac disease</topic><topic>Celiac Disease - genetics</topic><topic>Celiac Disease - immunology</topic><topic>Celiac Disease - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical data</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genotype</topic><topic>Histology</topic><topic>HLA</topic><topic>HLA-DQ Antigens - genetics</topic><topic>HLA-DQ beta-Chains</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Radioimmunoassay</topic><topic>Risk Factors</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Transglutaminases - immunology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nenna, Raffaella</creatorcontrib><creatorcontrib>Mora, Barbara</creatorcontrib><creatorcontrib>Megiorni, Francesca</creatorcontrib><creatorcontrib>Mazzilli, Maria Cristina</creatorcontrib><creatorcontrib>Magliocca, Fabio Massimo</creatorcontrib><creatorcontrib>Tiberti, Claudio</creatorcontrib><creatorcontrib>Bonamico, Margherita</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nenna, Raffaella</au><au>Mora, Barbara</au><au>Megiorni, Francesca</au><au>Mazzilli, Maria Cristina</au><au>Magliocca, Fabio Massimo</au><au>Tiberti, Claudio</au><au>Bonamico, Margherita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA‐DQB102 Dose Effect on RIA Anti‐tissue Transglutaminase Autoantibody Levels and Clinicopathological Expressivity of Celiac Disease</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2008-09</date><risdate>2008</risdate><volume>47</volume><issue>3</issue><spage>288</spage><epage>292</epage><pages>288-292</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>ABSTRACT
Objectives:
Celiac disease is an autoimmune enteropathy caused by gluten ingestion in genetically susceptible individuals. Anti‐transglutaminase autoantibody (tTGAb) assay is useful to detect candidates undergoing intestinal biopsy. Our aim was to investigate whether the DQB1*02 allele could influence tTGAb titers and the clinicopathological expressivity of the disease.
Methods:
A total of 124 patients with celiac disease, tested for RIA tTGAb at diagnosis, were typed for HLA‐DRB1, ‐DQA1, and ‐DQB1 genes and divided according to the number of DQB1*02 alleles: group 1, homozygous; group 2, heterozygous; group 3, negative.
Results:
The mean of tTGAb indexes was significantly higher in group 1 patients than in group 2 (P < 0.02) and group 3 patients (P < 0.01). Patients with at least 1 DQB1*02 allele showed more often a typical CD and diffuse histological lesions than did patients in the other groups.
Conclusions:
The study demonstrates that tTGAb titers are HLA‐DQB1*02 dose dependent, with significantly higher levels in homozygous individuals. Moreover, individuals with at least 1 HLA‐DQB1*02 allele tend to have a more expressed clinical and histological form of celiac disease.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>18728523</pmid><doi>10.1097/MPG.0b013e3181615ca7</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library; Journals@Ovid Complete |
| subjects | Adolescent Adult Alleles Anti‐transglutaminase autoantibodies Autoantibodies - blood Biological and medical sciences Celiac disease Celiac Disease - genetics Celiac Disease - immunology Celiac Disease - pathology Child Child, Preschool Clinical data Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Genotype Histology HLA HLA-DQ Antigens - genetics HLA-DQ beta-Chains Humans Infant Male Medical sciences Other diseases. Semiology Radioimmunoassay Risk Factors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transglutaminases - immunology Vertebrates: anatomy and physiology, studies on body, several organs or systems Young Adult |
| title | HLA‐DQB102 Dose Effect on RIA Anti‐tissue Transglutaminase Autoantibody Levels and Clinicopathological Expressivity of Celiac Disease |
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