Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3β and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen–glucose deprivation-induced apoptosis in primary rat cortical neuronal cells

Only acylated ghrelin (AG) binds GH secretagog receptor 1a (GHS-R1a) and has central endocrine activities. An anti-apoptotic effect of AG in neuronal cells has recently been reported. However, whether there is a neuroprotective effect of unacylated ghrelin (UAG), the most abundant form of ghrelin in...

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Veröffentlicht in:	Journal of endocrinology 2008-09, Vol.198 (3), p.511-521
Hauptverfasser:	Chung, Hyunju, Seo, Sanghee, Moon, Minho, Park, Seungjoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Animals Apoptosis - drug effects Biological and medical sciences Blotting, Western Caspase 3 - metabolism Cell Hypoxia - physiology Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - metabolism Chromones - pharmacology Flavonoids - pharmacology Ghrelin - metabolism Ghrelin - pharmacology Glucose - deficiency Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Immunohistochemistry Medical sciences Miscellaneous Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - metabolism Morpholines - pharmacology Neurons - cytology Neurons - drug effects Neurons - metabolism Neuropharmacology Pharmacology. Drug treatments Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Receptors, Ghrelin - metabolism Regular papers Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering Signal Transduction - drug effects
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