P2Y2 receptor elevates intracellular calcium concentration in rabbit eye suprachoroid

Effects of ATP on the intracellular free calcium ion concentration ([Ca2+]i) in the rabbit eye suprachoroid were investigated by means of fura-2 microfluorophotometry. ATP application (10 to 100 microM) elicited a dose-dependent biphasic [Ca2+]i-increase: a fast phase typically peaking within 30 s a...

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Veröffentlicht in:	Journal of medical and dental sciences 1999-06, Vol.46 (2), p.83-92
Hauptverfasser:	Sugamoto, Y, Hirai, K, Tokoro, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Animals Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium Signaling - drug effects Choroid - drug effects Choroid - metabolism Cytophotometry Dentistry Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Estrenes - pharmacology Female Fluorescent Dyes Fura-2 Gallic Acid - analogs & derivatives Gallic Acid - pharmacology Male Phosphodiesterase Inhibitors - pharmacology Pyrrolidinones - pharmacology Rabbits Receptors, Purinergic P2 - drug effects Receptors, Purinergic P2 - physiology Receptors, Purinergic P2Y2 Sarcoplasmic Reticulum - drug effects Sarcoplasmic Reticulum - metabolism Statistics as Topic Suramin - pharmacology Thapsigargin - pharmacology Time Factors Type C Phospholipases - antagonists & inhibitors Uridine Triphosphate - pharmacology
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