Coordinate production of cephamycin c and clavulanic acid by Streptomyces clavuligerus
Production of cephamycin c and clavulanic acid by Streptomyces clavuligerus was investigated using different media in shake flask condition. Highest cell growth (3.8 g/L) was observed in glycerol, sucrose, proline and glutamic acid (GSPG) medium. Although, GSPG medium supported maximum growth, it wa...
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| Veröffentlicht in: | Indian journal of experimental biology 1999-10, Vol.37 (10), p.1031-1033 |
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| container_title | Indian journal of experimental biology |
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| creator | Thakur, R Roy, M K Dutta, N N Bezbaruah, R L |
| description | Production of cephamycin c and clavulanic acid by Streptomyces clavuligerus was investigated using different media in shake flask condition. Highest cell growth (3.8 g/L) was observed in glycerol, sucrose, proline and glutamic acid (GSPG) medium. Although, GSPG medium supported maximum growth, it was least effective for the synthesis of both cephamycin and clavulanic acid. Yield of cephamycin and clavulanic acid was maximum in dextrin and K medium, respectively. High and low level of constituents of dextrin medium, affected production of both cephamycin and clavulanic acid. Biosynthesis of clavulanic acid was associated with production of cephamycin c. |
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Highest cell growth (3.8 g/L) was observed in glycerol, sucrose, proline and glutamic acid (GSPG) medium. Although, GSPG medium supported maximum growth, it was least effective for the synthesis of both cephamycin and clavulanic acid. Yield of cephamycin and clavulanic acid was maximum in dextrin and K medium, respectively. High and low level of constituents of dextrin medium, affected production of both cephamycin and clavulanic acid. 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Highest cell growth (3.8 g/L) was observed in glycerol, sucrose, proline and glutamic acid (GSPG) medium. Although, GSPG medium supported maximum growth, it was least effective for the synthesis of both cephamycin and clavulanic acid. Yield of cephamycin and clavulanic acid was maximum in dextrin and K medium, respectively. High and low level of constituents of dextrin medium, affected production of both cephamycin and clavulanic acid. 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| ispartof | Indian journal of experimental biology, 1999-10, Vol.37 (10), p.1031-1033 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Anti-Bacterial Agents - biosynthesis cephamycin c Cephamycins - biosynthesis Clavulanic Acid - biosynthesis Culture Media Streptomyces - growth & development Streptomyces - metabolism Streptomyces clavuligerus |
| title | Coordinate production of cephamycin c and clavulanic acid by Streptomyces clavuligerus |
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