Is carbon dioxide (CO2) a useful short acting anaesthetic for small laboratory animals?
The anaesthetic effect of carbon dioxide (CO(2) was investigated under predetermined exposure times in rats, mice and guineapigs with admixture of 20% of oxygen (O(2)), and with 20% of ambient air in rats. In rats first symptoms (median) were detectable between 7 and 9.5 s, the induction time (media...
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Veröffentlicht in: | Laboratory animals (London) 1999-04, Vol.33 (2), p.155-161 |
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creator | Kohler, I Meier, R Busato, A Neiger-Aeschbacher, G Schatzmann, U |
description | The anaesthetic effect of carbon dioxide (CO(2) was investigated under predetermined exposure times in rats, mice and guineapigs with admixture of 20% of oxygen (O(2)), and with 20% of ambient air in rats. In rats first symptoms (median) were detectable between 7 and 9.5 s, the induction time (median) varied between 16 and 20.5 s and the surgical tolerance (median) was 40 s (after 60 s of exposure) and 53.5 s (after 120 s of exposure) to 80% CO(2)/20% O(2). When O(2) was replaced by ambient air, a surgical tolerance of 53.5 s (after 60 s of exposure) and 77 s (after 120 s of exposure) was measured. In mice the induction time to 80% CO(2)/20% O(2) was 10 s and the surgical tolerance 19.5 s (after 120 s of exposure). Guineapigs showed an induction period of 20 s and a surgical tolerance of 50 s (after 30 s of exposure) to 80% CO(2)/O(2). Recovery was short and smooth in all species. This method of general anaesthesia seems to be suitable for short and painful interventions, mainly in rats, but also in guineapigs. |
doi_str_mv | 10.1258/002367799780578390 |
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This method of general anaesthesia seems to be suitable for short and painful interventions, mainly in rats, but also in guineapigs.</description><identifier>ISSN: 0023-6772</identifier><identifier>EISSN: 1758-1117</identifier><identifier>DOI: 10.1258/002367799780578390</identifier><identifier>PMID: 10780819</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>anesthesia ; Anesthesia, Inhalation - methods ; Anesthesia, Inhalation - veterinary ; Animal Welfare ; Animals ; carbon dioxide ; Carbon Dioxide - administration & dosage ; Carbon Dioxide - pharmacology ; duration ; Female ; guinea pigs ; Guinea Pigs - physiology ; Male ; mice ; Mice - physiology ; Oxygen - administration & dosage ; Oxygen - pharmacology ; rats ; Rats - physiology ; species differences</subject><ispartof>Laboratory animals (London), 1999-04, Vol.33 (2), p.155-161</ispartof><rights>1999 Royal Society of Medicine Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-87607e2034b2f9d4791168f80dfaa5b0fff53438c8aa8547b0907dd241a43a4b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10780819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kohler, I</creatorcontrib><creatorcontrib>Meier, R</creatorcontrib><creatorcontrib>Busato, A</creatorcontrib><creatorcontrib>Neiger-Aeschbacher, G</creatorcontrib><creatorcontrib>Schatzmann, U</creatorcontrib><title>Is carbon dioxide (CO2) a useful short acting anaesthetic for small laboratory animals?</title><title>Laboratory animals (London)</title><addtitle>Lab Anim</addtitle><description>The anaesthetic effect of carbon dioxide (CO(2) was investigated under predetermined exposure times in rats, mice and guineapigs with admixture of 20% of oxygen (O(2)), and with 20% of ambient air in rats. In rats first symptoms (median) were detectable between 7 and 9.5 s, the induction time (median) varied between 16 and 20.5 s and the surgical tolerance (median) was 40 s (after 60 s of exposure) and 53.5 s (after 120 s of exposure) to 80% CO(2)/20% O(2). When O(2) was replaced by ambient air, a surgical tolerance of 53.5 s (after 60 s of exposure) and 77 s (after 120 s of exposure) was measured. In mice the induction time to 80% CO(2)/20% O(2) was 10 s and the surgical tolerance 19.5 s (after 120 s of exposure). Guineapigs showed an induction period of 20 s and a surgical tolerance of 50 s (after 30 s of exposure) to 80% CO(2)/O(2). Recovery was short and smooth in all species. This method of general anaesthesia seems to be suitable for short and painful interventions, mainly in rats, but also in guineapigs.</description><subject>anesthesia</subject><subject>Anesthesia, Inhalation - methods</subject><subject>Anesthesia, Inhalation - veterinary</subject><subject>Animal Welfare</subject><subject>Animals</subject><subject>carbon dioxide</subject><subject>Carbon Dioxide - administration & dosage</subject><subject>Carbon Dioxide - pharmacology</subject><subject>duration</subject><subject>Female</subject><subject>guinea pigs</subject><subject>Guinea Pigs - physiology</subject><subject>Male</subject><subject>mice</subject><subject>Mice - physiology</subject><subject>Oxygen - administration & dosage</subject><subject>Oxygen - pharmacology</subject><subject>rats</subject><subject>Rats - physiology</subject><subject>species differences</subject><issn>0023-6772</issn><issn>1758-1117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LxDAQxYMoun78Ax40J9FD3UmabpKTyOIXCB508RimbbJb6TaatKD_vZHuQRA8DTP83uPNI-SYwSXjhZoC8HwmpdZSQSFVrmGLTJgsVMYYk9tk8gNkieB7ZD_Gt7QyoWCX7DFIEsX0hLw-RFphKH1H68Z_NrWl5_MnfkGRDtG6oaVx5UNPseqbbkmxQxv7le2bijofaFxj29IWSx-w9-ErAU06xatDsuPStEebeUAWtzcv8_vs8enuYX79mFUCZJ8pOQNpOeSi5E7XQmrGZsopqB1iUYJzrshFriqFqAohS9Ag65oLhiJHUeYH5Gz0fQ_-Y0jZzLqJlW1b7KwfoplpIUFLSCAfwSr4GIN15j2kqOHLMDA_dZq_dSbRycZ9KNe2_iUZ-0vAdAQiLq1580Po0rf_W56OCofe4DI00SyeObAcuGaFTJ7fPPaFUA</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Kohler, I</creator><creator>Meier, R</creator><creator>Busato, A</creator><creator>Neiger-Aeschbacher, G</creator><creator>Schatzmann, U</creator><general>SAGE Publications</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>Is carbon dioxide (CO2) a useful short acting anaesthetic for small laboratory animals?</title><author>Kohler, I ; Meier, R ; Busato, A ; Neiger-Aeschbacher, G ; Schatzmann, U</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-87607e2034b2f9d4791168f80dfaa5b0fff53438c8aa8547b0907dd241a43a4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>anesthesia</topic><topic>Anesthesia, Inhalation - methods</topic><topic>Anesthesia, Inhalation - veterinary</topic><topic>Animal Welfare</topic><topic>Animals</topic><topic>carbon dioxide</topic><topic>Carbon Dioxide - administration & dosage</topic><topic>Carbon Dioxide - pharmacology</topic><topic>duration</topic><topic>Female</topic><topic>guinea pigs</topic><topic>Guinea Pigs - physiology</topic><topic>Male</topic><topic>mice</topic><topic>Mice - physiology</topic><topic>Oxygen - administration & dosage</topic><topic>Oxygen - pharmacology</topic><topic>rats</topic><topic>Rats - physiology</topic><topic>species differences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kohler, I</creatorcontrib><creatorcontrib>Meier, R</creatorcontrib><creatorcontrib>Busato, A</creatorcontrib><creatorcontrib>Neiger-Aeschbacher, G</creatorcontrib><creatorcontrib>Schatzmann, U</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Laboratory animals (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kohler, I</au><au>Meier, R</au><au>Busato, A</au><au>Neiger-Aeschbacher, G</au><au>Schatzmann, U</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is carbon dioxide (CO2) a useful short acting anaesthetic for small laboratory animals?</atitle><jtitle>Laboratory animals (London)</jtitle><addtitle>Lab Anim</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>33</volume><issue>2</issue><spage>155</spage><epage>161</epage><pages>155-161</pages><issn>0023-6772</issn><eissn>1758-1117</eissn><abstract>The anaesthetic effect of carbon dioxide (CO(2) was investigated under predetermined exposure times in rats, mice and guineapigs with admixture of 20% of oxygen (O(2)), and with 20% of ambient air in rats. In rats first symptoms (median) were detectable between 7 and 9.5 s, the induction time (median) varied between 16 and 20.5 s and the surgical tolerance (median) was 40 s (after 60 s of exposure) and 53.5 s (after 120 s of exposure) to 80% CO(2)/20% O(2). When O(2) was replaced by ambient air, a surgical tolerance of 53.5 s (after 60 s of exposure) and 77 s (after 120 s of exposure) was measured. In mice the induction time to 80% CO(2)/20% O(2) was 10 s and the surgical tolerance 19.5 s (after 120 s of exposure). Guineapigs showed an induction period of 20 s and a surgical tolerance of 50 s (after 30 s of exposure) to 80% CO(2)/O(2). Recovery was short and smooth in all species. This method of general anaesthesia seems to be suitable for short and painful interventions, mainly in rats, but also in guineapigs.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>10780819</pmid><doi>10.1258/002367799780578390</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | anesthesia Anesthesia, Inhalation - methods Anesthesia, Inhalation - veterinary Animal Welfare Animals carbon dioxide Carbon Dioxide - administration & dosage Carbon Dioxide - pharmacology duration Female guinea pigs Guinea Pigs - physiology Male mice Mice - physiology Oxygen - administration & dosage Oxygen - pharmacology rats Rats - physiology species differences |
title | Is carbon dioxide (CO2) a useful short acting anaesthetic for small laboratory animals? |
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