Transcutaneous electrogastrography in patients with ileus. Relations to interleukin-1beta, interleukin-6, procalcitonin and C-reactive protein
The aim of the prospective study was to characterize the disturbance of gastric electrical control activity in different types of ileus and to correlate surface electrogastrography (EGG) findings with a set of inflammatory markers. Fifty-four adult patients with mechanic, vascular and paralytic ileu...
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| Veröffentlicht in: | European surgical research 2008, Vol.41 (2), p.197-202 |
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| creator | Frasko, R Maruna, P Gurlich, R Trca, S |
| description | The aim of the prospective study was to characterize the disturbance of gastric electrical control activity in different types of ileus and to correlate surface electrogastrography (EGG) findings with a set of inflammatory markers.
Fifty-four adult patients with mechanic, vascular and paralytic ileus proven on clinical and radiological exams and 14 age- and sex-matched controls were examined. Gastric myoelectrical activity was recorded using 3 Ag-AgCl disposable skin electrodes connected in pseudo-unipolar mode by Microdigitrapper device. The captured signal was amplified and digitalized. The dominant frequency was calculated using computerized algorithms (Fast Fourier transform and running spectrum analysis). The results were correlated with the known pathological diagnoses and 4 inflammatory parameters--interleukin (IL)-1beta, IL-6, procalcitonin (PCT) and C-reactive protein.
Irregular EGG activity without a dominant frequency or bradygastria (electrical control activity frequency |
| doi_str_mv | 10.1159/000134918 |
| format | Article |
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Fifty-four adult patients with mechanic, vascular and paralytic ileus proven on clinical and radiological exams and 14 age- and sex-matched controls were examined. Gastric myoelectrical activity was recorded using 3 Ag-AgCl disposable skin electrodes connected in pseudo-unipolar mode by Microdigitrapper device. The captured signal was amplified and digitalized. The dominant frequency was calculated using computerized algorithms (Fast Fourier transform and running spectrum analysis). The results were correlated with the known pathological diagnoses and 4 inflammatory parameters--interleukin (IL)-1beta, IL-6, procalcitonin (PCT) and C-reactive protein.
Irregular EGG activity without a dominant frequency or bradygastria (electrical control activity frequency <2.4 cycles/min) was seen in all patients with both vascular and parayltic ileus and in 67.86% of the patients with obstructive ileus. Normogastria (2.4-3.7 cycles/min) was found in 32.14% of the patients with obstructive ileus. Among the patients with obstructive ileus and bradygastria, higher concentrations of IL-6 (642.0 +/- 214.7 ng/l) and PCT (0.93 +/- 0.22 microg/l) were observed compared with the patients with normogastria--IL-6 (354.5 +/- 109.2 ng/l), PCT (0.69 +/- 0.11 microg/l); p < 0.05 for both. The C-reactive protein concentration did not differ in both subgroups on p < 0.05.
EGG examination confirmed a high sensitivity in the evaluation of gastric electrical control activity in both vascular and paralytic ileus. Significant correlation of EGG findings and both IL-6 and PCT plasma levels supports a role of the inflammatory milieu in the pathogenesis of impaired gastric electrical activity in patients with ileus.</description><identifier>EISSN: 1421-9921</identifier><identifier>DOI: 10.1159/000134918</identifier><identifier>PMID: 18504369</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Adult ; Aged ; Biomarkers - blood ; C-Reactive Protein - metabolism ; Calcitonin - blood ; Calcitonin Gene-Related Peptide ; Electrodes ; Electrodiagnosis - instrumentation ; Electrodiagnosis - methods ; Female ; Humans ; Ileus - diagnosis ; Ileus - immunology ; Ileus - physiopathology ; Interleukin-1beta - blood ; Interleukin-6 - blood ; Male ; Middle Aged ; Prospective Studies ; Protein Precursors - blood ; Sensitivity and Specificity ; Transcutaneous Electric Nerve Stimulation</subject><ispartof>European surgical research, 2008, Vol.41 (2), p.197-202</ispartof><rights>2008 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18504369$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frasko, R</creatorcontrib><creatorcontrib>Maruna, P</creatorcontrib><creatorcontrib>Gurlich, R</creatorcontrib><creatorcontrib>Trca, S</creatorcontrib><title>Transcutaneous electrogastrography in patients with ileus. Relations to interleukin-1beta, interleukin-6, procalcitonin and C-reactive protein</title><title>European surgical research</title><addtitle>Eur Surg Res</addtitle><description>The aim of the prospective study was to characterize the disturbance of gastric electrical control activity in different types of ileus and to correlate surface electrogastrography (EGG) findings with a set of inflammatory markers.
Fifty-four adult patients with mechanic, vascular and paralytic ileus proven on clinical and radiological exams and 14 age- and sex-matched controls were examined. Gastric myoelectrical activity was recorded using 3 Ag-AgCl disposable skin electrodes connected in pseudo-unipolar mode by Microdigitrapper device. The captured signal was amplified and digitalized. The dominant frequency was calculated using computerized algorithms (Fast Fourier transform and running spectrum analysis). The results were correlated with the known pathological diagnoses and 4 inflammatory parameters--interleukin (IL)-1beta, IL-6, procalcitonin (PCT) and C-reactive protein.
Irregular EGG activity without a dominant frequency or bradygastria (electrical control activity frequency <2.4 cycles/min) was seen in all patients with both vascular and parayltic ileus and in 67.86% of the patients with obstructive ileus. Normogastria (2.4-3.7 cycles/min) was found in 32.14% of the patients with obstructive ileus. Among the patients with obstructive ileus and bradygastria, higher concentrations of IL-6 (642.0 +/- 214.7 ng/l) and PCT (0.93 +/- 0.22 microg/l) were observed compared with the patients with normogastria--IL-6 (354.5 +/- 109.2 ng/l), PCT (0.69 +/- 0.11 microg/l); p < 0.05 for both. The C-reactive protein concentration did not differ in both subgroups on p < 0.05.
EGG examination confirmed a high sensitivity in the evaluation of gastric electrical control activity in both vascular and paralytic ileus. Significant correlation of EGG findings and both IL-6 and PCT plasma levels supports a role of the inflammatory milieu in the pathogenesis of impaired gastric electrical activity in patients with ileus.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Calcitonin - blood</subject><subject>Calcitonin Gene-Related Peptide</subject><subject>Electrodes</subject><subject>Electrodiagnosis - instrumentation</subject><subject>Electrodiagnosis - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Ileus - diagnosis</subject><subject>Ileus - immunology</subject><subject>Ileus - physiopathology</subject><subject>Interleukin-1beta - blood</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Protein Precursors - blood</subject><subject>Sensitivity and Specificity</subject><subject>Transcutaneous Electric Nerve Stimulation</subject><issn>1421-9921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM1OwzAQhC0kREvhwAsgnzg1xT9xEh9RxZ9UCQn1HjnOhhpcJ9gOqC_BM-Oq5cBlV5oZfasdhK4oWVAq5C0hhPJc0uoETWnOaCYloxN0HsJ7coQs5Rma0EqQnBdyin7WXrmgx6gc9GPAYEFH37-psJ9eDZsdNg4PKhpwMeBvEzfYWBjDAr-CTXLvAo59CkXwSf8wLqMNRDX_JxVzPPheK6tN7F0iKtfiZeZB6Wi-YG9GMO4CnXbKBrg87hlaP9yvl0_Z6uXxeXm3ygaRy4wq0mgqoOWdKBnpGOecNYxABaAESe-XTBZdRUQBmolUCJFQak0UF22lKz5DNwdsOvs5Qoj11gQN1h5aqAuZF5Im6gxdH4Njs4W2HrzZKr-r_wrkvx7fcg4</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Frasko, R</creator><creator>Maruna, P</creator><creator>Gurlich, R</creator><creator>Trca, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Transcutaneous electrogastrography in patients with ileus. Relations to interleukin-1beta, interleukin-6, procalcitonin and C-reactive protein</title><author>Frasko, R ; Maruna, P ; Gurlich, R ; Trca, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p549-1a0bc15ed3f5720f23332b20e8eea503497296f8056ec2501309e7cc0a35d8c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Calcitonin - blood</topic><topic>Calcitonin Gene-Related Peptide</topic><topic>Electrodes</topic><topic>Electrodiagnosis - instrumentation</topic><topic>Electrodiagnosis - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Ileus - diagnosis</topic><topic>Ileus - immunology</topic><topic>Ileus - physiopathology</topic><topic>Interleukin-1beta - blood</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Protein Precursors - blood</topic><topic>Sensitivity and Specificity</topic><topic>Transcutaneous Electric Nerve Stimulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frasko, R</creatorcontrib><creatorcontrib>Maruna, P</creatorcontrib><creatorcontrib>Gurlich, R</creatorcontrib><creatorcontrib>Trca, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frasko, R</au><au>Maruna, P</au><au>Gurlich, R</au><au>Trca, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcutaneous electrogastrography in patients with ileus. Relations to interleukin-1beta, interleukin-6, procalcitonin and C-reactive protein</atitle><jtitle>European surgical research</jtitle><addtitle>Eur Surg Res</addtitle><date>2008</date><risdate>2008</risdate><volume>41</volume><issue>2</issue><spage>197</spage><epage>202</epage><pages>197-202</pages><eissn>1421-9921</eissn><abstract>The aim of the prospective study was to characterize the disturbance of gastric electrical control activity in different types of ileus and to correlate surface electrogastrography (EGG) findings with a set of inflammatory markers.
Fifty-four adult patients with mechanic, vascular and paralytic ileus proven on clinical and radiological exams and 14 age- and sex-matched controls were examined. Gastric myoelectrical activity was recorded using 3 Ag-AgCl disposable skin electrodes connected in pseudo-unipolar mode by Microdigitrapper device. The captured signal was amplified and digitalized. The dominant frequency was calculated using computerized algorithms (Fast Fourier transform and running spectrum analysis). The results were correlated with the known pathological diagnoses and 4 inflammatory parameters--interleukin (IL)-1beta, IL-6, procalcitonin (PCT) and C-reactive protein.
Irregular EGG activity without a dominant frequency or bradygastria (electrical control activity frequency <2.4 cycles/min) was seen in all patients with both vascular and parayltic ileus and in 67.86% of the patients with obstructive ileus. Normogastria (2.4-3.7 cycles/min) was found in 32.14% of the patients with obstructive ileus. Among the patients with obstructive ileus and bradygastria, higher concentrations of IL-6 (642.0 +/- 214.7 ng/l) and PCT (0.93 +/- 0.22 microg/l) were observed compared with the patients with normogastria--IL-6 (354.5 +/- 109.2 ng/l), PCT (0.69 +/- 0.11 microg/l); p < 0.05 for both. The C-reactive protein concentration did not differ in both subgroups on p < 0.05.
EGG examination confirmed a high sensitivity in the evaluation of gastric electrical control activity in both vascular and paralytic ileus. Significant correlation of EGG findings and both IL-6 and PCT plasma levels supports a role of the inflammatory milieu in the pathogenesis of impaired gastric electrical activity in patients with ileus.</abstract><cop>Switzerland</cop><pmid>18504369</pmid><doi>10.1159/000134918</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Biomarkers - blood C-Reactive Protein - metabolism Calcitonin - blood Calcitonin Gene-Related Peptide Electrodes Electrodiagnosis - instrumentation Electrodiagnosis - methods Female Humans Ileus - diagnosis Ileus - immunology Ileus - physiopathology Interleukin-1beta - blood Interleukin-6 - blood Male Middle Aged Prospective Studies Protein Precursors - blood Sensitivity and Specificity Transcutaneous Electric Nerve Stimulation |
| title | Transcutaneous electrogastrography in patients with ileus. Relations to interleukin-1beta, interleukin-6, procalcitonin and C-reactive protein |
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