The impact of employment status on recipient and renal allograft survival
: Background: With the improved median survival of kidney transplant recipients, there has been an increased focus on quality of life after transplantation. Employment is a widely recognized component of quality of life. To date, no study has demonstrated a link between post‐transplant employment s...
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| Veröffentlicht in: | Clinical transplantation 2008-07, Vol.22 (4), p.428-438 |
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| creator | Petersen, Emily Baird, Bradley C. Barenbaum, Lev L. Leviatov, Alexander Koford, James K. Shihab, Fuad Goldfarb-Rumyantzev, Alexander S. |
| description | : Background: With the improved median survival of kidney transplant recipients, there has been an increased focus on quality of life after transplantation. Employment is a widely recognized component of quality of life. To date, no study has demonstrated a link between post‐transplant employment status and recipient and allograft survival after transplant.
Methods: The records from the United States Renal Data System (USRDS) and the United Network for Organ Sharing (UNOS) from January 1, 1995, through December 31, 2002, were examined in this retrospective study. Two outcomes, allograft survival time (time between the transplantation and allograft failure or censor) and recipient survival time (time between the transplantation and recipient death or censor), were analyzed using Cox models adjusted for potential confounding factors.
Results: Compared to patients working full time at the time of transplantation, those not working by choice have a greater risk to graft [hazard ratio (HR) 1.27, p |
| doi_str_mv | 10.1111/j.1399-0012.2008.00803.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69468344</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69468344</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4343-f8c172df505aa79163841cf97c5d2595a30c8a407b91698f2288561d2ce96d693</originalsourceid><addsrcrecordid>eNqNkE1vEzEQhi0EatPQv1DtBW67-GPttSUuKGrTigqkKIijNfXaZYP3A3u3JP8eL4nCFUuWxzPPa8-8CGUEFyStD7uCMKVyjAktKMaySBuzYv8KLc6F12iBFaYpFuwSXcW4S1lBBL9Al0QyQsuSLdDD9ofNmnYAM2a9y2w7-P7Q2m7M4gjjFLO-y4I1zdDMOejqdOvAZ-B9_xzAJW4KL80L-LfojQMf7fXpXKJvd7fb1X3--HX9sPr0mJuSlSx30pCK1o5jDlApIpgsiXGqMrymXHFg2EgocfWUako6SqXkgtTUWCVqodgSvT--O4T-12TjqNsmGus9dLafohaqFJKl4ZZIHkET-hiDdXoITQvhoAnWs416p2e39OyWnm3Uf23U-yS9Of0xPbW2_ic8-ZaAdycAogHvAnSmiWeOYs4pUTJxH4_c78bbw383oFfbTQqSPD_Kmzja_VkO4acWFau4_v5lrdmabsRGftZ37A8sfZtn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69468344</pqid></control><display><type>article</type><title>The impact of employment status on recipient and renal allograft survival</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Petersen, Emily ; Baird, Bradley C. ; Barenbaum, Lev L. ; Leviatov, Alexander ; Koford, James K. ; Shihab, Fuad ; Goldfarb-Rumyantzev, Alexander S.</creator><creatorcontrib>Petersen, Emily ; Baird, Bradley C. ; Barenbaum, Lev L. ; Leviatov, Alexander ; Koford, James K. ; Shihab, Fuad ; Goldfarb-Rumyantzev, Alexander S.</creatorcontrib><description>: Background: With the improved median survival of kidney transplant recipients, there has been an increased focus on quality of life after transplantation. Employment is a widely recognized component of quality of life. To date, no study has demonstrated a link between post‐transplant employment status and recipient and allograft survival after transplant.
Methods: The records from the United States Renal Data System (USRDS) and the United Network for Organ Sharing (UNOS) from January 1, 1995, through December 31, 2002, were examined in this retrospective study. Two outcomes, allograft survival time (time between the transplantation and allograft failure or censor) and recipient survival time (time between the transplantation and recipient death or censor), were analyzed using Cox models adjusted for potential confounding factors.
Results: Compared to patients working full time at the time of transplantation, those not working by choice have a greater risk to graft [hazard ratio (HR) 1.27, p < 0.001] but not to recipient survival. A similar trend was observed in patients not working at 12 months post‐transplant (HR 1.30, p < 0.001 for graft survival but not for recipient survival). However, at five‐yr post‐transplant not working by choice was protective to the graft (HR 0.47, p < 0.01) as compared to working full time. Results of the analysis in the patient subgroups based on the comorbidities and the overall health status were similar.
Conclusion: Employment status at the time of transplantation and in post‐transplant period has a strong and independent association with the graft and recipient survival. Full time employment at the time of transplant and at one‐yr post‐transplant is associated with lower risk for graft failure and recipient mortality. However, working beyond the time covered by Medicare might be associated with potential risk for graft survival.</description><identifier>ISSN: 0902-0063</identifier><identifier>EISSN: 1399-0012</identifier><identifier>DOI: 10.1111/j.1399-0012.2008.00803.x</identifier><identifier>PMID: 18312443</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Employment ; employment status ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; General aspects ; Graft Rejection - epidemiology ; Graft Rejection - surgery ; Graft Survival ; Humans ; Kidney - surgery ; Kidney Transplantation ; Male ; Medical sciences ; Middle Aged ; outcome ; prediction ; public health ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Quality of Life ; recipient survival ; renal transplant ; Retrospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Survival Rate ; Tissue, organ and graft immunology ; Transplantation, Homologous</subject><ispartof>Clinical transplantation, 2008-07, Vol.22 (4), p.428-438</ispartof><rights>2008 Wiley Periodicals, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4343-f8c172df505aa79163841cf97c5d2595a30c8a407b91698f2288561d2ce96d693</citedby><cites>FETCH-LOGICAL-c4343-f8c172df505aa79163841cf97c5d2595a30c8a407b91698f2288561d2ce96d693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-0012.2008.00803.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-0012.2008.00803.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20552198$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18312443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petersen, Emily</creatorcontrib><creatorcontrib>Baird, Bradley C.</creatorcontrib><creatorcontrib>Barenbaum, Lev L.</creatorcontrib><creatorcontrib>Leviatov, Alexander</creatorcontrib><creatorcontrib>Koford, James K.</creatorcontrib><creatorcontrib>Shihab, Fuad</creatorcontrib><creatorcontrib>Goldfarb-Rumyantzev, Alexander S.</creatorcontrib><title>The impact of employment status on recipient and renal allograft survival</title><title>Clinical transplantation</title><addtitle>Clin Transplant</addtitle><description>: Background: With the improved median survival of kidney transplant recipients, there has been an increased focus on quality of life after transplantation. Employment is a widely recognized component of quality of life. To date, no study has demonstrated a link between post‐transplant employment status and recipient and allograft survival after transplant.
Methods: The records from the United States Renal Data System (USRDS) and the United Network for Organ Sharing (UNOS) from January 1, 1995, through December 31, 2002, were examined in this retrospective study. Two outcomes, allograft survival time (time between the transplantation and allograft failure or censor) and recipient survival time (time between the transplantation and recipient death or censor), were analyzed using Cox models adjusted for potential confounding factors.
Results: Compared to patients working full time at the time of transplantation, those not working by choice have a greater risk to graft [hazard ratio (HR) 1.27, p < 0.001] but not to recipient survival. A similar trend was observed in patients not working at 12 months post‐transplant (HR 1.30, p < 0.001 for graft survival but not for recipient survival). However, at five‐yr post‐transplant not working by choice was protective to the graft (HR 0.47, p < 0.01) as compared to working full time. Results of the analysis in the patient subgroups based on the comorbidities and the overall health status were similar.
Conclusion: Employment status at the time of transplantation and in post‐transplant period has a strong and independent association with the graft and recipient survival. Full time employment at the time of transplant and at one‐yr post‐transplant is associated with lower risk for graft failure and recipient mortality. However, working beyond the time covered by Medicare might be associated with potential risk for graft survival.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Employment</subject><subject>employment status</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>General aspects</subject><subject>Graft Rejection - epidemiology</subject><subject>Graft Rejection - surgery</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>Kidney - surgery</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>outcome</subject><subject>prediction</subject><subject>public health</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Quality of Life</subject><subject>recipient survival</subject><subject>renal transplant</subject><subject>Retrospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Survival Rate</subject><subject>Tissue, organ and graft immunology</subject><subject>Transplantation, Homologous</subject><issn>0902-0063</issn><issn>1399-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1vEzEQhi0EatPQv1DtBW67-GPttSUuKGrTigqkKIijNfXaZYP3A3u3JP8eL4nCFUuWxzPPa8-8CGUEFyStD7uCMKVyjAktKMaySBuzYv8KLc6F12iBFaYpFuwSXcW4S1lBBL9Al0QyQsuSLdDD9ofNmnYAM2a9y2w7-P7Q2m7M4gjjFLO-y4I1zdDMOejqdOvAZ-B9_xzAJW4KL80L-LfojQMf7fXpXKJvd7fb1X3--HX9sPr0mJuSlSx30pCK1o5jDlApIpgsiXGqMrymXHFg2EgocfWUako6SqXkgtTUWCVqodgSvT--O4T-12TjqNsmGus9dLafohaqFJKl4ZZIHkET-hiDdXoITQvhoAnWs416p2e39OyWnm3Uf23U-yS9Of0xPbW2_ic8-ZaAdycAogHvAnSmiWeOYs4pUTJxH4_c78bbw383oFfbTQqSPD_Kmzja_VkO4acWFau4_v5lrdmabsRGftZ37A8sfZtn</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Petersen, Emily</creator><creator>Baird, Bradley C.</creator><creator>Barenbaum, Lev L.</creator><creator>Leviatov, Alexander</creator><creator>Koford, James K.</creator><creator>Shihab, Fuad</creator><creator>Goldfarb-Rumyantzev, Alexander S.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200807</creationdate><title>The impact of employment status on recipient and renal allograft survival</title><author>Petersen, Emily ; Baird, Bradley C. ; Barenbaum, Lev L. ; Leviatov, Alexander ; Koford, James K. ; Shihab, Fuad ; Goldfarb-Rumyantzev, Alexander S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4343-f8c172df505aa79163841cf97c5d2595a30c8a407b91698f2288561d2ce96d693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Employment</topic><topic>employment status</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>General aspects</topic><topic>Graft Rejection - epidemiology</topic><topic>Graft Rejection - surgery</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>Kidney - surgery</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>outcome</topic><topic>prediction</topic><topic>public health</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Quality of Life</topic><topic>recipient survival</topic><topic>renal transplant</topic><topic>Retrospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Survival Rate</topic><topic>Tissue, organ and graft immunology</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petersen, Emily</creatorcontrib><creatorcontrib>Baird, Bradley C.</creatorcontrib><creatorcontrib>Barenbaum, Lev L.</creatorcontrib><creatorcontrib>Leviatov, Alexander</creatorcontrib><creatorcontrib>Koford, James K.</creatorcontrib><creatorcontrib>Shihab, Fuad</creatorcontrib><creatorcontrib>Goldfarb-Rumyantzev, Alexander S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petersen, Emily</au><au>Baird, Bradley C.</au><au>Barenbaum, Lev L.</au><au>Leviatov, Alexander</au><au>Koford, James K.</au><au>Shihab, Fuad</au><au>Goldfarb-Rumyantzev, Alexander S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of employment status on recipient and renal allograft survival</atitle><jtitle>Clinical transplantation</jtitle><addtitle>Clin Transplant</addtitle><date>2008-07</date><risdate>2008</risdate><volume>22</volume><issue>4</issue><spage>428</spage><epage>438</epage><pages>428-438</pages><issn>0902-0063</issn><eissn>1399-0012</eissn><abstract>: Background: With the improved median survival of kidney transplant recipients, there has been an increased focus on quality of life after transplantation. Employment is a widely recognized component of quality of life. To date, no study has demonstrated a link between post‐transplant employment status and recipient and allograft survival after transplant.
Methods: The records from the United States Renal Data System (USRDS) and the United Network for Organ Sharing (UNOS) from January 1, 1995, through December 31, 2002, were examined in this retrospective study. Two outcomes, allograft survival time (time between the transplantation and allograft failure or censor) and recipient survival time (time between the transplantation and recipient death or censor), were analyzed using Cox models adjusted for potential confounding factors.
Results: Compared to patients working full time at the time of transplantation, those not working by choice have a greater risk to graft [hazard ratio (HR) 1.27, p < 0.001] but not to recipient survival. A similar trend was observed in patients not working at 12 months post‐transplant (HR 1.30, p < 0.001 for graft survival but not for recipient survival). However, at five‐yr post‐transplant not working by choice was protective to the graft (HR 0.47, p < 0.01) as compared to working full time. Results of the analysis in the patient subgroups based on the comorbidities and the overall health status were similar.
Conclusion: Employment status at the time of transplantation and in post‐transplant period has a strong and independent association with the graft and recipient survival. Full time employment at the time of transplant and at one‐yr post‐transplant is associated with lower risk for graft failure and recipient mortality. However, working beyond the time covered by Medicare might be associated with potential risk for graft survival.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18312443</pmid><doi>10.1111/j.1399-0012.2008.00803.x</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Employment employment status Epidemiology Female Fundamental and applied biological sciences. Psychology Fundamental immunology General aspects Graft Rejection - epidemiology Graft Rejection - surgery Graft Survival Humans Kidney - surgery Kidney Transplantation Male Medical sciences Middle Aged outcome prediction public health Public health. Hygiene Public health. Hygiene-occupational medicine Quality of Life recipient survival renal transplant Retrospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Survival Rate Tissue, organ and graft immunology Transplantation, Homologous |
| title | The impact of employment status on recipient and renal allograft survival |
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