Chaotropic salts: Novel modifiers for the capillary electrophoretic analysis of benzodiazepines
This paper describes a CE method for analyzing benzodiazepines using the chaotropic salts lithium trifluoromethanesulfonate (LiOTf), lithium hexafluorophosphate (LiPF6), and lithium bis(trifluoromethanesulfonyl)imide (LiNTf2) as modifiers in the running buffer. Although adequate resolution of seven...
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| Veröffentlicht in: | Electrophoresis 2008-08, Vol.29 (16), p.3384-3390 |
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| creator | Su, Hsiu-Li Lan, Min-Tsu Lin, Kuan-Wen Hsieh, You-Zung |
| description | This paper describes a CE method for analyzing benzodiazepines using the chaotropic salts lithium trifluoromethanesulfonate (LiOTf), lithium hexafluorophosphate (LiPF6), and lithium bis(trifluoromethanesulfonyl)imide (LiNTf2) as modifiers in the running buffer. Although adequate resolution of seven benzodiazepine analytes occurred under the influence of each of the chaotropic anions, the separation efficiency was highest when bis(trifluoromethanesulfonyl)imide (Tf2N−) was the modifier. We applied affinity CE in conjunction with linear analysis to determine the association constants for the formation of complexes between the Tf2N− anion and the benzodiazepines. According to the estimated Gibbs free energies, the interactions between this chaotropic anion and the benzodiazepines were either ion–dipole or ion–induced dipole interactions. Adding chaotropic salts as modifiers into CE buffers is a simple and reproducible technique for separating benzodiazepines. |
| doi_str_mv | 10.1002/elps.200800073 |
| format | Article |
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Although adequate resolution of seven benzodiazepine analytes occurred under the influence of each of the chaotropic anions, the separation efficiency was highest when bis(trifluoromethanesulfonyl)imide (Tf2N−) was the modifier. We applied affinity CE in conjunction with linear analysis to determine the association constants for the formation of complexes between the Tf2N− anion and the benzodiazepines. According to the estimated Gibbs free energies, the interactions between this chaotropic anion and the benzodiazepines were either ion–dipole or ion–induced dipole interactions. 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Although adequate resolution of seven benzodiazepine analytes occurred under the influence of each of the chaotropic anions, the separation efficiency was highest when bis(trifluoromethanesulfonyl)imide (Tf2N−) was the modifier. We applied affinity CE in conjunction with linear analysis to determine the association constants for the formation of complexes between the Tf2N− anion and the benzodiazepines. According to the estimated Gibbs free energies, the interactions between this chaotropic anion and the benzodiazepines were either ion–dipole or ion–induced dipole interactions. Adding chaotropic salts as modifiers into CE buffers is a simple and reproducible technique for separating benzodiazepines.</description><subject>Affinity capillary electrophoresis</subject><subject>Anions - chemistry</subject><subject>Benzodiazepine</subject><subject>Benzodiazepines - analysis</subject><subject>Benzodiazepines - isolation & purification</subject><subject>Capillary electrophoresis</subject><subject>Chaotropic salt</subject><subject>Electrophoresis, Capillary - methods</subject><subject>Ionic liquid</subject><subject>Lithium Compounds - chemistry</subject><subject>Salts - chemistry</subject><issn>0173-0835</issn><issn>1522-2683</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPGzEURi1EBSllyxJ5xW5SP8djdlXEo1KUIpWqS8vjuaMYnHhqT1rCr6-jRLQ7Vt6cc-T7IXRByZQSwj5DGPKUEdIQQhQ_QhMqGatY3fBjNCFU8Yo0XJ6ijzk_FURoIU7QKW0UYaRmE2RmSxvHFAfvcLZhzNd4EX9DwKvY-d5DyriPCY9LwM4OPgSbthgCuJ2zjAnGItq1DdvsM449bmH9WlT7CoNfQ_6EPvQ2ZDg_vGfox-3N4-y-mn-7-zr7Mq-coIxXvaOqcY6xRhMrNKNakIZqrYTqbKtZJ7qmb5WgreSWS2K51lKLWluQtpeCn6GrfXdI8dcG8mhWPjso_11D3GRTF1hxpd4FuaBUlngBp3vQpZhzgt4Mya_K-YYSs9ve7LY3b9sX4fJQ3rQr6P7hh7ELoPfAHx9g-07O3Mwfvv8fr_auzyO8vLk2PZvdXdL8XNwZNVcP6nFRm3v-F-P4oFM</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Su, Hsiu-Li</creator><creator>Lan, Min-Tsu</creator><creator>Lin, Kuan-Wen</creator><creator>Hsieh, You-Zung</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Chaotropic salts: Novel modifiers for the capillary electrophoretic analysis of benzodiazepines</title><author>Su, Hsiu-Li ; Lan, Min-Tsu ; Lin, Kuan-Wen ; Hsieh, You-Zung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4123-fc178cc22890a49219408199747dab92d4d8fb741b53a350a39959469ae5af543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Affinity capillary electrophoresis</topic><topic>Anions - chemistry</topic><topic>Benzodiazepine</topic><topic>Benzodiazepines - analysis</topic><topic>Benzodiazepines - isolation & purification</topic><topic>Capillary electrophoresis</topic><topic>Chaotropic salt</topic><topic>Electrophoresis, Capillary - methods</topic><topic>Ionic liquid</topic><topic>Lithium Compounds - chemistry</topic><topic>Salts - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Hsiu-Li</creatorcontrib><creatorcontrib>Lan, Min-Tsu</creatorcontrib><creatorcontrib>Lin, Kuan-Wen</creatorcontrib><creatorcontrib>Hsieh, You-Zung</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Electrophoresis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Hsiu-Li</au><au>Lan, Min-Tsu</au><au>Lin, Kuan-Wen</au><au>Hsieh, You-Zung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chaotropic salts: Novel modifiers for the capillary electrophoretic analysis of benzodiazepines</atitle><jtitle>Electrophoresis</jtitle><addtitle>ELECTROPHORESIS</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>29</volume><issue>16</issue><spage>3384</spage><epage>3390</epage><pages>3384-3390</pages><issn>0173-0835</issn><eissn>1522-2683</eissn><abstract>This paper describes a CE method for analyzing benzodiazepines using the chaotropic salts lithium trifluoromethanesulfonate (LiOTf), lithium hexafluorophosphate (LiPF6), and lithium bis(trifluoromethanesulfonyl)imide (LiNTf2) as modifiers in the running buffer. Although adequate resolution of seven benzodiazepine analytes occurred under the influence of each of the chaotropic anions, the separation efficiency was highest when bis(trifluoromethanesulfonyl)imide (Tf2N−) was the modifier. We applied affinity CE in conjunction with linear analysis to determine the association constants for the formation of complexes between the Tf2N− anion and the benzodiazepines. According to the estimated Gibbs free energies, the interactions between this chaotropic anion and the benzodiazepines were either ion–dipole or ion–induced dipole interactions. Adding chaotropic salts as modifiers into CE buffers is a simple and reproducible technique for separating benzodiazepines.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>18702062</pmid><doi>10.1002/elps.200800073</doi><tpages>7</tpages></addata></record> |
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| ispartof | Electrophoresis, 2008-08, Vol.29 (16), p.3384-3390 |
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| subjects | Affinity capillary electrophoresis Anions - chemistry Benzodiazepine Benzodiazepines - analysis Benzodiazepines - isolation & purification Capillary electrophoresis Chaotropic salt Electrophoresis, Capillary - methods Ionic liquid Lithium Compounds - chemistry Salts - chemistry |
| title | Chaotropic salts: Novel modifiers for the capillary electrophoretic analysis of benzodiazepines |
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