Primary CNS lymphoma and HLA class I and II alleles in a German cohort of immunocompetent patients
Human leukocyte antigens (HLA) are involved in the regulation of immune response to infection and in malignant transformation. Several HLA alleles are associated with immunological or malignant diseases. The aim of the present study was to evaluate a potential association of HLA class I and II allel...
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| Veröffentlicht in: | Journal of neuro-oncology 2008-10, Vol.90 (1), p.53-55 |
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| container_title | Journal of neuro-oncology |
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| creator | Kurzwelly, Delia Müller, Claudia A. Korfel, Agnieszka Thiel, Eckhard Linnebank, Michael Weller, Michael Herrlinger, Ulrich |
| description | Human leukocyte antigens (HLA) are involved in the regulation of immune response to infection and in malignant transformation. Several HLA alleles are associated with immunological or malignant diseases. The aim of the present study was to evaluate a potential association of HLA class I and II alleles with primary central nervous system lymphoma (PCNSL) in immunocompetent patients. We therefore analyzed particular HLA-A, HLA-B and HLA-DRB1 alleles in 82 PCNSL patients and compared the data to those in 327 population controls. No significant difference between these two groups was found using Pearson’s χ
2
test. These data do not support the hypothesis that HLA alleles play a major role in the pathogenesis of PCNSL. |
| doi_str_mv | 10.1007/s11060-008-9630-5 |
| format | Article |
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2
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2
test. These data do not support the hypothesis that HLA alleles play a major role in the pathogenesis of PCNSL.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Central Nervous System Neoplasms - genetics</subject><subject>Clinical Trials, Phase IV as Topic</subject><subject>Clinical-Patient Studies</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Germany</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>Humans</subject><subject>Lymphoma, Non-Hodgkin - genetics</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multicenter Studies as Topic</subject><subject>Neurology</subject><subject>Oncology</subject><issn>0167-594X</issn><issn>1573-7373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkUtLxDAUhYMoOj5-gBsJLtxV82iSZimDjgODCiq4C2maaqVpatIu_Pdm7IAgiK4OIV9Ozr0HgGOMzjFC4iJijDjKECoyySnK2BaYYSZoJqig22CGMBcZk_nzHtiP8Q0hlAuKd8EeLlghGBUzUN6HxunwAee3D7D9cP2rdxrqroI3q0toWh0jXH6dl0na1rY2wqaDGi5scLqDxr_6MEBfw8a5sfPGu94Othtgr4cmaTwEO7Vuoz3a6AF4ur56nN9kq7vFcn65ykwu8iETHJUSkwJJQayuiWCFRrSUQouaEkkko5WxnFZVxUStacpvalHlxhYlwQk9AGeTbx_8-2jjoFwTjW1b3Vk_RsVlzpks8J8gloxLmbP_gGmJtEjg6Q_wzY-hS9MqgiUnqYd1PjxBJvgYg61VP-1eYaTWfaqpT5X6VOs-1TrBycZ4LJ2tvl9sCkwAmYCYrroXG75__t31E9GEqNo</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Kurzwelly, Delia</creator><creator>Müller, Claudia A.</creator><creator>Korfel, Agnieszka</creator><creator>Thiel, Eckhard</creator><creator>Linnebank, Michael</creator><creator>Weller, Michael</creator><creator>Herrlinger, Ulrich</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>Primary CNS lymphoma and HLA class I and II alleles in a German cohort of immunocompetent patients</title><author>Kurzwelly, Delia ; 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2
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| subjects | Adolescent Adult Aged Central Nervous System Neoplasms - genetics Clinical Trials, Phase IV as Topic Clinical-Patient Studies European Continental Ancestry Group Female Genetic Predisposition to Disease Germany Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class II - genetics Humans Lymphoma, Non-Hodgkin - genetics Male Medicine Medicine & Public Health Middle Aged Multicenter Studies as Topic Neurology Oncology |
| title | Primary CNS lymphoma and HLA class I and II alleles in a German cohort of immunocompetent patients |
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