Gene transfer by guanidinium‐cholesterol: dioleoylphosphatidyl‐ethanolamine liposome‐DNA complexes in aerosol

Background A major challenge of gene therapy is the efficient transfer of genes to cell sites where effective transfection can occur. The impact of jet nebulization on DNA structural and functional integrity has been problematic for the aerosol delivery of genes to pulmonary sites and remains a seri...

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Veröffentlicht in:	The journal of gene medicine 1999-07, Vol.1 (4), p.251-264
Hauptverfasser:	Densmore, Charles L., Giddings, Thomas H., Waldrep, J. Clifford, Kinsey, Berma M., Knight, Vernon
Format:	Artikel
Sprache:	eng
Schlagworte:	aerosol Aerosols beta-Galactosidase - genetics cationic lipid Cell Line Chloramphenicol O-Acetyltransferase - genetics Cholesterol Cytomegalovirus - genetics DNA - administration & dosage DNA - genetics DOPE Gene therapy Gene Transfer Techniques Genes, Reporter Genetic Vectors Guanidine guanidinium cholesterol Humans liposome Liposomes Lung - enzymology Microscopy, Electron Nebulizers and Vaporizers Phosphatidylethanolamines Transfection
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