The Atg18-Atg2 Complex Is Recruited to Autophagic Membranes via Phosphatidylinositol 3-Phosphate and Exerts an Essential Function

Atg18 is essential for both autophagy and the regulation of vacuolar morphology. The latter process is mediated by phosphatidylinositol 3,5-bisphosphate binding, which is dispensable for autophagy. Atg18 also binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) in vitro. Here, we investigate the r...

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Veröffentlicht in:	The Journal of biological chemistry 2008-08, Vol.283 (35), p.23972-23980
Hauptverfasser:	Obara, Keisuke, Sekito, Takayuki, Niimi, Kaori, Ohsumi, Yoshinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation - physiology Autophagy - physiology Autophagy-Related Proteins Cell Membrane - genetics Cell Membrane - metabolism Endosomes - genetics Endosomes - metabolism Membrane Proteins Membrane Transport, Structure, Function, and Biogenesis Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Phosphatidylinositol Phosphates - genetics Phosphatidylinositol Phosphates - metabolism Protein Binding - physiology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Vacuoles - genetics Vacuoles - metabolism
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