Naked plasmid-mediated gene transfer to skeletal muscle ameliorates diabetes mellitus

Background The ability of tissues to take up naked plasmid DNA in vivo suggests an approach for reconstituting systemic metabolic deficiencies without the disadvantages of viral vectors and lipid‐DNA complexes. Plasmid‐mediated gene transfer into skeletal muscle was investigated as a means of provid...

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Veröffentlicht in:The journal of gene medicine 1999-05, Vol.1 (3), p.186-194
Hauptverfasser: Kon, Oi Lian, Sivakumar, Sasirekha, Teoh, Khay Lin, Lok, Serene HL, Long, Yun Chau
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Sprache:eng
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