Jadomycin B, an Aurora-B kinase inhibitor discovered through virtual screening

Aurora kinases have emerged as promising targets for cancer therapy because of their critical role in mitosis. These kinases are well-conserved in all eukaryotes, and IPL1 gene encodes the single Aurora kinase in budding yeast. In a virtual screening attempt, 22 compounds were identified from nearly...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cancer therapeutics 2008-08, Vol.7 (8), p.2386-2393
Hauptverfasser:	Fu, Da-Hua, Jiang, Wei, Zheng, Jian-Ting, Zhao, Gui-Yu, Li, Yan, Yi, Hong, Li, Zhuo-Rong, Jiang, Jian-Dong, Yang, Ke-Qian, Wang, Yanchang, Si, Shu-Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	antitumor agent Aurora Kinase B Aurora Kinases Aurora-B kinase inhibitor Blotting, Western Cell Line Cell Proliferation - drug effects Drug Evaluation, Preclinical Flow Cytometry Histones - antagonists & inhibitors Histones - metabolism Humans Isoquinolines - chemistry Isoquinolines - pharmacology Jadomycin B Molecular Structure natural product Phosphorylation Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein-Serine-Threonine Kinases - antagonists & inhibitors Recombinant Proteins - antagonists & inhibitors virtual screening
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!