Skin-Autofluorescence, a Measure of Tissue Advanced Glycation End-Products (AGEs), is Related to Diastolic Function in Dialysis Patients
Abstract Background Diastolic dysfunction is a frequent cause of heart failure, particularly in dialysis patients. Advanced glycation endproducts (AGEs) are increased in dialysis patients and are suggested to play a role in the development of diastolic dysfunction. The aim of our study was to assess...
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| Veröffentlicht in: | Journal of cardiac failure 2008-09, Vol.14 (7), p.596-602 |
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| creator | Hartog, Jasper W.L., MD Hummel, Yoran M., BSc Voors, Adriaan A., MD, PhD Schalkwijk, Casper G., PhD Miyata, Toshio, MD, PhD Huisman, Roel M., MD, PhD Smit, Andries J., MD, PhD Van Veldhuisen, Dirk J., MD, PhD |
| description | Abstract Background Diastolic dysfunction is a frequent cause of heart failure, particularly in dialysis patients. Advanced glycation endproducts (AGEs) are increased in dialysis patients and are suggested to play a role in the development of diastolic dysfunction. The aim of our study was to assess whether AGE accumulation in dialysis patients is related to the presence of diastolic dysfunction. Methods and Results Data were analyzed from 43 dialysis patients, age 58 ± 15 years, of whom 65% were male. Diastolic function was assessed using tissue velocity imaging (TVI) on echocardiography. Tissue AGE accumulation was measured using a validated skin-autofluorescence (skin-AF) reader. Plasma Nϵ -(carboxymethyl)lysine (CML) and Nϵ -(carboxyethyl)lysine (CEL) were measured by stable-isotope-dilution tandem mass spectrometry. Plasma pentosidine was measured by high-performance liquid chromatography. Skin-AF correlated with mean E′ ( r = −0.51, P < .001), E/A ratio ( r = −0.39, P = .014), and E/E′ ( r = 0.38, P = .019). Plasma AGEs were not significantly associated with diastolic function. Multivariable linear regression analysis revealed that 54% of the variance of average E′ was explained by age ( P = .007), dialysis type ( P = 0.016), and skin-AF ( P = .013). Conclusions Tissue AGEs measured as skin-AF, but not plasma AGE levels, were related to diastolic function in dialysis patients. Although this may support the concept that tissue AGEs explain part of the increased prevalence of diastolic dysfunction in these patients, the ambiguous relation between plasma and tissue AGEs needs further exploring. |
| doi_str_mv | 10.1016/j.cardfail.2008.03.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69460639</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S107191640800122X</els_id><sourcerecordid>69460639</sourcerecordid><originalsourceid>FETCH-LOGICAL-c487t-75dd9be14ff32def86c135c873e76e44985659c872e8112772814bbcdd1d72473</originalsourceid><addsrcrecordid>eNqFkl1rFDEUhgdRbK3-hZIrUeiM-Zpk5kZc6nYVKhZbwbuQTc5AttmkTWYK-w_82Wa6WwRvvHrz8Zz3cD6q6pTghmAiPmwao5MdtPMNxbhrMGuKPKuOScto3XHCn5czlqTuieBH1aucN7gQHMuX1RHpJKWMiuPq9_WtC_ViGuPgp5ggGwgGzpBG30DnKQGKA7pxOU-AFvZBl0-LVn5n9OhiQMtg66sU7WTGjN4tVsv8_gy5jH6A12Mhx4g-O53H6J1BF1Mwj1EuzK9-lwt5VYwgjPl19WLQPsObg55UPy-WN-df6svvq6_ni8va8E6OtWyt7ddA-DAwamHohCGsNZ1kIAVw3netaPtyp9ARQqWkHeHrtbGWWEm5ZCfV273vXYr3E-RRbV0p2nsdIE5ZiZ4LLFhfQLEHTYo5JxjUXXJbnXaKYDXPQG3U0wzUPAOFmSpSAk8PGab1FuzfsEPTC_BpD0Cp88FBUtm4ue3WJTCjstH9P8fHfyyMd8EZ7W9hB3kTpxRKFxVRmSqsrudNmBcBdxgTSn-xP2g8sHg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69460639</pqid></control><display><type>article</type><title>Skin-Autofluorescence, a Measure of Tissue Advanced Glycation End-Products (AGEs), is Related to Diastolic Function in Dialysis Patients</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Hartog, Jasper W.L., MD ; Hummel, Yoran M., BSc ; Voors, Adriaan A., MD, PhD ; Schalkwijk, Casper G., PhD ; Miyata, Toshio, MD, PhD ; Huisman, Roel M., MD, PhD ; Smit, Andries J., MD, PhD ; Van Veldhuisen, Dirk J., MD, PhD</creator><creatorcontrib>Hartog, Jasper W.L., MD ; Hummel, Yoran M., BSc ; Voors, Adriaan A., MD, PhD ; Schalkwijk, Casper G., PhD ; Miyata, Toshio, MD, PhD ; Huisman, Roel M., MD, PhD ; Smit, Andries J., MD, PhD ; Van Veldhuisen, Dirk J., MD, PhD</creatorcontrib><description>Abstract Background Diastolic dysfunction is a frequent cause of heart failure, particularly in dialysis patients. Advanced glycation endproducts (AGEs) are increased in dialysis patients and are suggested to play a role in the development of diastolic dysfunction. The aim of our study was to assess whether AGE accumulation in dialysis patients is related to the presence of diastolic dysfunction. Methods and Results Data were analyzed from 43 dialysis patients, age 58 ± 15 years, of whom 65% were male. Diastolic function was assessed using tissue velocity imaging (TVI) on echocardiography. Tissue AGE accumulation was measured using a validated skin-autofluorescence (skin-AF) reader. Plasma Nϵ -(carboxymethyl)lysine (CML) and Nϵ -(carboxyethyl)lysine (CEL) were measured by stable-isotope-dilution tandem mass spectrometry. Plasma pentosidine was measured by high-performance liquid chromatography. Skin-AF correlated with mean E′ ( r = −0.51, P < .001), E/A ratio ( r = −0.39, P = .014), and E/E′ ( r = 0.38, P = .019). Plasma AGEs were not significantly associated with diastolic function. Multivariable linear regression analysis revealed that 54% of the variance of average E′ was explained by age ( P = .007), dialysis type ( P = 0.016), and skin-AF ( P = .013). Conclusions Tissue AGEs measured as skin-AF, but not plasma AGE levels, were related to diastolic function in dialysis patients. Although this may support the concept that tissue AGEs explain part of the increased prevalence of diastolic dysfunction in these patients, the ambiguous relation between plasma and tissue AGEs needs further exploring.</description><identifier>ISSN: 1071-9164</identifier><identifier>EISSN: 1532-8414</identifier><identifier>DOI: 10.1016/j.cardfail.2008.03.008</identifier><identifier>PMID: 18722326</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age Factors ; Arginine - analogs & derivatives ; Arginine - blood ; Arginine - pharmacokinetics ; carboxymethyllysine ; Cardiac Volume - physiology ; Cardiovascular ; Chromatography, High Pressure Liquid ; Cross-Sectional Studies ; Echocardiography ; Echocardiography, Doppler ; Echocardiography, Doppler, Color ; Female ; Fluorescence ; Glycation End Products, Advanced - analysis ; Glycation End Products, Advanced - blood ; Glycation End Products, Advanced - pharmacokinetics ; Heart failure ; Heart Failure, Diastolic - etiology ; Heart Failure, Diastolic - physiopathology ; Humans ; Lysine - analogs & derivatives ; Lysine - blood ; Lysine - pharmacokinetics ; Male ; Middle Aged ; Myocardial Contraction - physiology ; Renal Dialysis - classification ; Risk Factors ; Sex Factors ; Skin - metabolism ; Skin - physiopathology ; Stroke Volume - physiology ; Tandem Mass Spectrometry ; tissue velocity imaging ; Ventricular Dysfunction - etiology ; Ventricular Dysfunction - physiopathology ; Ventricular Function - physiology ; Ventricular Pressure - physiology</subject><ispartof>Journal of cardiac failure, 2008-09, Vol.14 (7), p.596-602</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-75dd9be14ff32def86c135c873e76e44985659c872e8112772814bbcdd1d72473</citedby><cites>FETCH-LOGICAL-c487t-75dd9be14ff32def86c135c873e76e44985659c872e8112772814bbcdd1d72473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cardfail.2008.03.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18722326$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hartog, Jasper W.L., MD</creatorcontrib><creatorcontrib>Hummel, Yoran M., BSc</creatorcontrib><creatorcontrib>Voors, Adriaan A., MD, PhD</creatorcontrib><creatorcontrib>Schalkwijk, Casper G., PhD</creatorcontrib><creatorcontrib>Miyata, Toshio, MD, PhD</creatorcontrib><creatorcontrib>Huisman, Roel M., MD, PhD</creatorcontrib><creatorcontrib>Smit, Andries J., MD, PhD</creatorcontrib><creatorcontrib>Van Veldhuisen, Dirk J., MD, PhD</creatorcontrib><title>Skin-Autofluorescence, a Measure of Tissue Advanced Glycation End-Products (AGEs), is Related to Diastolic Function in Dialysis Patients</title><title>Journal of cardiac failure</title><addtitle>J Card Fail</addtitle><description>Abstract Background Diastolic dysfunction is a frequent cause of heart failure, particularly in dialysis patients. Advanced glycation endproducts (AGEs) are increased in dialysis patients and are suggested to play a role in the development of diastolic dysfunction. The aim of our study was to assess whether AGE accumulation in dialysis patients is related to the presence of diastolic dysfunction. Methods and Results Data were analyzed from 43 dialysis patients, age 58 ± 15 years, of whom 65% were male. Diastolic function was assessed using tissue velocity imaging (TVI) on echocardiography. Tissue AGE accumulation was measured using a validated skin-autofluorescence (skin-AF) reader. Plasma Nϵ -(carboxymethyl)lysine (CML) and Nϵ -(carboxyethyl)lysine (CEL) were measured by stable-isotope-dilution tandem mass spectrometry. Plasma pentosidine was measured by high-performance liquid chromatography. Skin-AF correlated with mean E′ ( r = −0.51, P < .001), E/A ratio ( r = −0.39, P = .014), and E/E′ ( r = 0.38, P = .019). Plasma AGEs were not significantly associated with diastolic function. Multivariable linear regression analysis revealed that 54% of the variance of average E′ was explained by age ( P = .007), dialysis type ( P = 0.016), and skin-AF ( P = .013). Conclusions Tissue AGEs measured as skin-AF, but not plasma AGE levels, were related to diastolic function in dialysis patients. Although this may support the concept that tissue AGEs explain part of the increased prevalence of diastolic dysfunction in these patients, the ambiguous relation between plasma and tissue AGEs needs further exploring.</description><subject>Age Factors</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - blood</subject><subject>Arginine - pharmacokinetics</subject><subject>carboxymethyllysine</subject><subject>Cardiac Volume - physiology</subject><subject>Cardiovascular</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cross-Sectional Studies</subject><subject>Echocardiography</subject><subject>Echocardiography, Doppler</subject><subject>Echocardiography, Doppler, Color</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Glycation End Products, Advanced - analysis</subject><subject>Glycation End Products, Advanced - blood</subject><subject>Glycation End Products, Advanced - pharmacokinetics</subject><subject>Heart failure</subject><subject>Heart Failure, Diastolic - etiology</subject><subject>Heart Failure, Diastolic - physiopathology</subject><subject>Humans</subject><subject>Lysine - analogs & derivatives</subject><subject>Lysine - blood</subject><subject>Lysine - pharmacokinetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Contraction - physiology</subject><subject>Renal Dialysis - classification</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Skin - metabolism</subject><subject>Skin - physiopathology</subject><subject>Stroke Volume - physiology</subject><subject>Tandem Mass Spectrometry</subject><subject>tissue velocity imaging</subject><subject>Ventricular Dysfunction - etiology</subject><subject>Ventricular Dysfunction - physiopathology</subject><subject>Ventricular Function - physiology</subject><subject>Ventricular Pressure - physiology</subject><issn>1071-9164</issn><issn>1532-8414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl1rFDEUhgdRbK3-hZIrUeiM-Zpk5kZc6nYVKhZbwbuQTc5AttmkTWYK-w_82Wa6WwRvvHrz8Zz3cD6q6pTghmAiPmwao5MdtPMNxbhrMGuKPKuOScto3XHCn5czlqTuieBH1aucN7gQHMuX1RHpJKWMiuPq9_WtC_ViGuPgp5ggGwgGzpBG30DnKQGKA7pxOU-AFvZBl0-LVn5n9OhiQMtg66sU7WTGjN4tVsv8_gy5jH6A12Mhx4g-O53H6J1BF1Mwj1EuzK9-lwt5VYwgjPl19WLQPsObg55UPy-WN-df6svvq6_ni8va8E6OtWyt7ddA-DAwamHohCGsNZ1kIAVw3netaPtyp9ARQqWkHeHrtbGWWEm5ZCfV273vXYr3E-RRbV0p2nsdIE5ZiZ4LLFhfQLEHTYo5JxjUXXJbnXaKYDXPQG3U0wzUPAOFmSpSAk8PGab1FuzfsEPTC_BpD0Cp88FBUtm4ue3WJTCjstH9P8fHfyyMd8EZ7W9hB3kTpxRKFxVRmSqsrudNmBcBdxgTSn-xP2g8sHg</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Hartog, Jasper W.L., MD</creator><creator>Hummel, Yoran M., BSc</creator><creator>Voors, Adriaan A., MD, PhD</creator><creator>Schalkwijk, Casper G., PhD</creator><creator>Miyata, Toshio, MD, PhD</creator><creator>Huisman, Roel M., MD, PhD</creator><creator>Smit, Andries J., MD, PhD</creator><creator>Van Veldhuisen, Dirk J., MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080901</creationdate><title>Skin-Autofluorescence, a Measure of Tissue Advanced Glycation End-Products (AGEs), is Related to Diastolic Function in Dialysis Patients</title><author>Hartog, Jasper W.L., MD ; Hummel, Yoran M., BSc ; Voors, Adriaan A., MD, PhD ; Schalkwijk, Casper G., PhD ; Miyata, Toshio, MD, PhD ; Huisman, Roel M., MD, PhD ; Smit, Andries J., MD, PhD ; Van Veldhuisen, Dirk J., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-75dd9be14ff32def86c135c873e76e44985659c872e8112772814bbcdd1d72473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Age Factors</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - blood</topic><topic>Arginine - pharmacokinetics</topic><topic>carboxymethyllysine</topic><topic>Cardiac Volume - physiology</topic><topic>Cardiovascular</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cross-Sectional Studies</topic><topic>Echocardiography</topic><topic>Echocardiography, Doppler</topic><topic>Echocardiography, Doppler, Color</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Glycation End Products, Advanced - analysis</topic><topic>Glycation End Products, Advanced - blood</topic><topic>Glycation End Products, Advanced - pharmacokinetics</topic><topic>Heart failure</topic><topic>Heart Failure, Diastolic - etiology</topic><topic>Heart Failure, Diastolic - physiopathology</topic><topic>Humans</topic><topic>Lysine - analogs & derivatives</topic><topic>Lysine - blood</topic><topic>Lysine - pharmacokinetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Contraction - physiology</topic><topic>Renal Dialysis - classification</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Skin - metabolism</topic><topic>Skin - physiopathology</topic><topic>Stroke Volume - physiology</topic><topic>Tandem Mass Spectrometry</topic><topic>tissue velocity imaging</topic><topic>Ventricular Dysfunction - etiology</topic><topic>Ventricular Dysfunction - physiopathology</topic><topic>Ventricular Function - physiology</topic><topic>Ventricular Pressure - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hartog, Jasper W.L., MD</creatorcontrib><creatorcontrib>Hummel, Yoran M., BSc</creatorcontrib><creatorcontrib>Voors, Adriaan A., MD, PhD</creatorcontrib><creatorcontrib>Schalkwijk, Casper G., PhD</creatorcontrib><creatorcontrib>Miyata, Toshio, MD, PhD</creatorcontrib><creatorcontrib>Huisman, Roel M., MD, PhD</creatorcontrib><creatorcontrib>Smit, Andries J., MD, PhD</creatorcontrib><creatorcontrib>Van Veldhuisen, Dirk J., MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiac failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hartog, Jasper W.L., MD</au><au>Hummel, Yoran M., BSc</au><au>Voors, Adriaan A., MD, PhD</au><au>Schalkwijk, Casper G., PhD</au><au>Miyata, Toshio, MD, PhD</au><au>Huisman, Roel M., MD, PhD</au><au>Smit, Andries J., MD, PhD</au><au>Van Veldhuisen, Dirk J., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skin-Autofluorescence, a Measure of Tissue Advanced Glycation End-Products (AGEs), is Related to Diastolic Function in Dialysis Patients</atitle><jtitle>Journal of cardiac failure</jtitle><addtitle>J Card Fail</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>14</volume><issue>7</issue><spage>596</spage><epage>602</epage><pages>596-602</pages><issn>1071-9164</issn><eissn>1532-8414</eissn><abstract>Abstract Background Diastolic dysfunction is a frequent cause of heart failure, particularly in dialysis patients. Advanced glycation endproducts (AGEs) are increased in dialysis patients and are suggested to play a role in the development of diastolic dysfunction. The aim of our study was to assess whether AGE accumulation in dialysis patients is related to the presence of diastolic dysfunction. Methods and Results Data were analyzed from 43 dialysis patients, age 58 ± 15 years, of whom 65% were male. Diastolic function was assessed using tissue velocity imaging (TVI) on echocardiography. Tissue AGE accumulation was measured using a validated skin-autofluorescence (skin-AF) reader. Plasma Nϵ -(carboxymethyl)lysine (CML) and Nϵ -(carboxyethyl)lysine (CEL) were measured by stable-isotope-dilution tandem mass spectrometry. Plasma pentosidine was measured by high-performance liquid chromatography. Skin-AF correlated with mean E′ ( r = −0.51, P < .001), E/A ratio ( r = −0.39, P = .014), and E/E′ ( r = 0.38, P = .019). Plasma AGEs were not significantly associated with diastolic function. Multivariable linear regression analysis revealed that 54% of the variance of average E′ was explained by age ( P = .007), dialysis type ( P = 0.016), and skin-AF ( P = .013). Conclusions Tissue AGEs measured as skin-AF, but not plasma AGE levels, were related to diastolic function in dialysis patients. Although this may support the concept that tissue AGEs explain part of the increased prevalence of diastolic dysfunction in these patients, the ambiguous relation between plasma and tissue AGEs needs further exploring.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18722326</pmid><doi>10.1016/j.cardfail.2008.03.008</doi><tpages>7</tpages></addata></record> |
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| subjects | Age Factors Arginine - analogs & derivatives Arginine - blood Arginine - pharmacokinetics carboxymethyllysine Cardiac Volume - physiology Cardiovascular Chromatography, High Pressure Liquid Cross-Sectional Studies Echocardiography Echocardiography, Doppler Echocardiography, Doppler, Color Female Fluorescence Glycation End Products, Advanced - analysis Glycation End Products, Advanced - blood Glycation End Products, Advanced - pharmacokinetics Heart failure Heart Failure, Diastolic - etiology Heart Failure, Diastolic - physiopathology Humans Lysine - analogs & derivatives Lysine - blood Lysine - pharmacokinetics Male Middle Aged Myocardial Contraction - physiology Renal Dialysis - classification Risk Factors Sex Factors Skin - metabolism Skin - physiopathology Stroke Volume - physiology Tandem Mass Spectrometry tissue velocity imaging Ventricular Dysfunction - etiology Ventricular Dysfunction - physiopathology Ventricular Function - physiology Ventricular Pressure - physiology |
| title | Skin-Autofluorescence, a Measure of Tissue Advanced Glycation End-Products (AGEs), is Related to Diastolic Function in Dialysis Patients |
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