Designed metal-binding sites in biomolecular and bioinorganic interactions

Designed metal-binding sites in biomolecular and bioinorganic interactions

The design of metal-binding functionality in proteins is expanding into many different areas with a wide range of practical and research applications. Here we review several developing areas of metal-related protein design, including the use of metals to induce protein–protein interactions or facili...

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Veröffentlicht in:Current opinion in structural biology 2008-08, Vol.18 (4), p.484-490
Hauptverfasser: Matthews, Jacqueline M, Loughlin, Fionna E, Mackay, Joel P
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Sprache:eng
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Binding Sites
Metals - metabolism
Models, Molecular
Proteins - metabolism
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container_issue 4
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container_title Current opinion in structural biology
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creator Matthews, Jacqueline M
Loughlin, Fionna E
Mackay, Joel P
description The design of metal-binding functionality in proteins is expanding into many different areas with a wide range of practical and research applications. Here we review several developing areas of metal-related protein design, including the use of metals to induce protein–protein interactions or facilitate the assembly of extended nanostructures; the design of metallopeptides that bind metal and other inorganic surfaces, an area with potential in diverse applications ranging from nanoelectronics and photonics to biotechnology and biomedicine; and, the creation of sensitive and selective metal sensors for use both in vivo and in vitro.
doi_str_mv 10.1016/j.sbi.2008.04.009
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subjects Binding Sites
Metals - metabolism
Models, Molecular
Proteins - metabolism
title Designed metal-binding sites in biomolecular and bioinorganic interactions
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