Blebs lead the way: how to migrate without lamellipodia
Membrane blebs are considered to be a hallmark of apoptosis; however, blebs are also observed in healthy cells during cytokinesis and cell motility. What are the potential mechanisms by which blebbing can be polarized and translated into movement? And what are the advantages of blebbing motility? Bl...
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| Veröffentlicht in: | Nature reviews. Molecular cell biology 2008-09, Vol.9 (9), p.730-736 |
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| container_title | Nature reviews. Molecular cell biology |
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| creator | Charras, Guillaume Paluch, Ewa |
| description | Membrane blebs are considered to be a hallmark of apoptosis; however, blebs are also observed in healthy cells during cytokinesis and cell motility. What are the potential mechanisms by which blebbing can be polarized and translated into movement? And what are the advantages of blebbing motility?
Blebs are spherical membrane protrusions that are produced by contractions of the actomyosin cortex. Blebs are often considered to be a hallmark of apoptosis; however, blebs are also frequently observed during cytokinesis and during migration in three-dimensional cultures and
in vivo
. For tumour cells and a number of embryonic cells, blebbing migration seems to be a common alternative to the more extensively studied lamellipodium-based motility. We argue that blebs should be promoted to a more prominent place in the world of cellular protrusions. |
| doi_str_mv | 10.1038/nrm2453 |
| format | Article |
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Blebs are spherical membrane protrusions that are produced by contractions of the actomyosin cortex. Blebs are often considered to be a hallmark of apoptosis; however, blebs are also frequently observed during cytokinesis and during migration in three-dimensional cultures and
in vivo
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Blebs are spherical membrane protrusions that are produced by contractions of the actomyosin cortex. Blebs are often considered to be a hallmark of apoptosis; however, blebs are also frequently observed during cytokinesis and during migration in three-dimensional cultures and
in vivo
. For tumour cells and a number of embryonic cells, blebbing migration seems to be a common alternative to the more extensively studied lamellipodium-based motility. 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Molecular cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Charras, Guillaume</au><au>Paluch, Ewa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blebs lead the way: how to migrate without lamellipodia</atitle><jtitle>Nature reviews. Molecular cell biology</jtitle><stitle>Nat Rev Mol Cell Biol</stitle><addtitle>Nat Rev Mol Cell Biol</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>9</volume><issue>9</issue><spage>730</spage><epage>736</epage><pages>730-736</pages><issn>1471-0072</issn><eissn>1471-0080</eissn><abstract>Membrane blebs are considered to be a hallmark of apoptosis; however, blebs are also observed in healthy cells during cytokinesis and cell motility. What are the potential mechanisms by which blebbing can be polarized and translated into movement? And what are the advantages of blebbing motility?
Blebs are spherical membrane protrusions that are produced by contractions of the actomyosin cortex. Blebs are often considered to be a hallmark of apoptosis; however, blebs are also frequently observed during cytokinesis and during migration in three-dimensional cultures and
in vivo
. For tumour cells and a number of embryonic cells, blebbing migration seems to be a common alternative to the more extensively studied lamellipodium-based motility. We argue that blebs should be promoted to a more prominent place in the world of cellular protrusions.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18628785</pmid><doi>10.1038/nrm2453</doi><tpages>7</tpages></addata></record> |
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| subjects | Actin Animals Apoptosis Biochemistry Biomedical and Life Sciences Cancer Research Cell Biology Cell Movement Cytokinesis Developmental Biology Embryos Health aspects Kinases Life Sciences Motility opinion-2 Physiological aspects Proteins - metabolism Pseudopodia - metabolism Stem Cells |
| title | Blebs lead the way: how to migrate without lamellipodia |
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