Knockout Mice Reveal a Role for P2Y6 Receptor in Macrophages, Endothelial Cells, and Vascular Smooth Muscle Cells

P2Y receptors are G-protein-coupled receptors activated by extracellular nucleotides. The P2Y6 receptor is selectively activated by UDP, and its transcript has been detected in numerous organs, including the spleen, thymus, intestine, blood leukocytes, and aorta. To investigate the biological functi...

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Veröffentlicht in:	Molecular pharmacology 2008-09, Vol.74 (3), p.777-784
Hauptverfasser:	Bar, Isabelle, Guns, Pieter-Jan, Metallo, Jessica, Cammarata, Dorothée, Wilkin, Françoise, Boeynams, Jean-Marie, Bult, Hidde, Robaye, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - drug effects Aorta - metabolism Cytokines - biosynthesis Endothelial Cells - drug effects Endothelial Cells - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Gene Deletion Gene Expression Regulation - drug effects Inositol Phosphates - biosynthesis Lipopolysaccharides - pharmacology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - enzymology Macrophages, Peritoneal - metabolism MAP Kinase Signaling System - drug effects Mice Mice, Knockout Muscle Contraction - drug effects Muscle Relaxation - drug effects Muscle, Smooth, Vascular - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Nucleotides - pharmacology Phenylephrine - pharmacology Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Thioglycolates - pharmacology Vasomotor System - drug effects
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