Erythropoietin receptor-mediated Egr-1 activation: Structural requirements and functional implications

The transcription factor Egr-1 is encoded by an immediate early response gene and has been shown to be a key regulator in the induction of apoptosis, mitogenesis and differentiation. It is rapidly induced by different stimuli including the glycoprotein hormone erythropoietin. In this report, we anal...

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Veröffentlicht in:	Cellular signalling 2008-10, Vol.20 (10), p.1848-1854
Hauptverfasser:	Schulze, Christoph, Büchse, Tom, Mikkat, Stefan, Bittorf, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - drug effects Differentiation DNA - metabolism Early Growth Response Protein 1 - chemistry Early Growth Response Protein 1 - metabolism Egr-1 Erythroid Cells - cytology Erythroid Cells - drug effects Erythroid Cells - enzymology Erythropoietin receptor GTPase-Activating Proteins - metabolism Humans Immunoprecipitation Interleukin-3 - pharmacology Janus Kinase 2 - metabolism Mice Mitogen-Activated Protein Kinases - metabolism Mutant Proteins - metabolism Phosphotyrosine - metabolism Protein Binding - drug effects Ras/MAPK pathway Receptor, Epidermal Growth Factor - metabolism Receptors, Erythropoietin - chemistry Receptors, Erythropoietin - metabolism Recombinant Fusion Proteins - metabolism Signal Transduction - drug effects STAT Transcription Factors - metabolism Time Factors
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