Direct Assessments of the Antioxidant Effects of Propofol Medium Chain Triglyceride/Long Chain Triglyceride on the Brain of Stroke-prone Spontaneously Hypertensive Rats Using Electron Spin Resonance Spectroscopy
Antioxidant anesthetics such as propofol (2,6-diisopropylphenol) directly inhibit lipid peroxidation via the generation of reactive oxygen species. Currently, there are no other studies regarding the direct effects of propofol medium chain triglyceride/long chain triglyceride (MCT/LCT) on reactive o...
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| Veröffentlicht in: | Anesthesiology (Philadelphia) 2008-09, Vol.109 (3), p.426-435 |
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| creator | KOBAYASHI, Kyo YOSHINO, Fumihiko TAKAHASHI, Shun-Suke TODOKI, Kazuo MAEHATA, Yojiro KOMATSU, Tomoko YOSHIDA, Kazu-Lchi LEE, Masaichi-Chang-Il |
| description | Antioxidant anesthetics such as propofol (2,6-diisopropylphenol) directly inhibit lipid peroxidation via the generation of reactive oxygen species. Currently, there are no other studies regarding the direct effects of propofol medium chain triglyceride/long chain triglyceride (MCT/LCT) on reactive oxygen species generation or in experimental models of reactive oxygen species-induced oxidative stress in the brain.
The authors investigated the effects of propofol MCT/LCT on reactive oxygen species (hydroxyl radical or superoxide) by electron spin resonance spin trapping with 5,5-dimethyl-1-pyrroline-N-oxide. The effects of propofol MCT/LCT on oxidative stress in the brain of Wistar-Kyoto rats or stroke-prone spontaneously hypertensive rats were investigated by using an in vivo L-band electron spin resonance system to monitor the decay rate of 3-methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl as a nitroxyl spin probe.
These studies provided direct evidence that propofol MCT/LCT inhibited hydroxyl radical generation, but not superoxide generation. Regarding the hydroxyl radical from the Fenton system, it is likely to be due to the scavenging effects of vehicle. Anesthesia with propofol MCT/LCT reduced the degree of the high oxidative stress in the brain of stroke-prone spontaneously hypertensive rats.
The current data show that propofol, mixed with clinical reagents (propofol MCT/LCT), resulted in the down-regulation of high oxidative stress due to scavenging hydroxyl radical, as demonstrated by in vitro or in vivo electron spin resonance analysis. These results led to reduced levels of hydroxyl radical, formed by brain injury such as stroke, and may therefore provide advantages for neuroprotection during anesthesia for craniotomy, e.g., in cases of brain disease. |
| doi_str_mv | 10.1097/aln.0b013e318182a903 |
| format | Article |
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The authors investigated the effects of propofol MCT/LCT on reactive oxygen species (hydroxyl radical or superoxide) by electron spin resonance spin trapping with 5,5-dimethyl-1-pyrroline-N-oxide. The effects of propofol MCT/LCT on oxidative stress in the brain of Wistar-Kyoto rats or stroke-prone spontaneously hypertensive rats were investigated by using an in vivo L-band electron spin resonance system to monitor the decay rate of 3-methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl as a nitroxyl spin probe.
These studies provided direct evidence that propofol MCT/LCT inhibited hydroxyl radical generation, but not superoxide generation. Regarding the hydroxyl radical from the Fenton system, it is likely to be due to the scavenging effects of vehicle. Anesthesia with propofol MCT/LCT reduced the degree of the high oxidative stress in the brain of stroke-prone spontaneously hypertensive rats.
The current data show that propofol, mixed with clinical reagents (propofol MCT/LCT), resulted in the down-regulation of high oxidative stress due to scavenging hydroxyl radical, as demonstrated by in vitro or in vivo electron spin resonance analysis. These results led to reduced levels of hydroxyl radical, formed by brain injury such as stroke, and may therefore provide advantages for neuroprotection during anesthesia for craniotomy, e.g., in cases of brain disease.</description><identifier>ISSN: 0003-3022</identifier><identifier>EISSN: 1528-1175</identifier><identifier>DOI: 10.1097/aln.0b013e318182a903</identifier><identifier>PMID: 18719440</identifier><identifier>CODEN: ANESAV</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthetics, Intravenous - chemistry ; Anesthetics, Intravenous - pharmacology ; Animals ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Brain - drug effects ; Brain - metabolism ; Cardiology. Vascular system ; Cerebrovascular Circulation - drug effects ; Disease Models, Animal ; Electron Spin Resonance Spectroscopy - methods ; Hydrogen Peroxide - chemistry ; Hydrogen Peroxide - radiation effects ; Iron - chemistry ; Lipid Peroxidation - drug effects ; Male ; Medical sciences ; Oxidative Stress - drug effects ; Propofol - chemistry ; Propofol - pharmacology ; Rats ; Rats, Inbred SHR ; Rats, Wistar ; Reactive Oxygen Species - metabolism ; Superoxides - metabolism ; Triglycerides - chemistry ; Triglycerides - pharmacology ; Ultraviolet Rays</subject><ispartof>Anesthesiology (Philadelphia), 2008-09, Vol.109 (3), p.426-435</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-9dbda72701bc8f1d77cb8263646facaf55be27a2b5f45d58cfa796560a8ae8733</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20616203$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18719440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOBAYASHI, Kyo</creatorcontrib><creatorcontrib>YOSHINO, Fumihiko</creatorcontrib><creatorcontrib>TAKAHASHI, Shun-Suke</creatorcontrib><creatorcontrib>TODOKI, Kazuo</creatorcontrib><creatorcontrib>MAEHATA, Yojiro</creatorcontrib><creatorcontrib>KOMATSU, Tomoko</creatorcontrib><creatorcontrib>YOSHIDA, Kazu-Lchi</creatorcontrib><creatorcontrib>LEE, Masaichi-Chang-Il</creatorcontrib><title>Direct Assessments of the Antioxidant Effects of Propofol Medium Chain Triglyceride/Long Chain Triglyceride on the Brain of Stroke-prone Spontaneously Hypertensive Rats Using Electron Spin Resonance Spectroscopy</title><title>Anesthesiology (Philadelphia)</title><addtitle>Anesthesiology</addtitle><description>Antioxidant anesthetics such as propofol (2,6-diisopropylphenol) directly inhibit lipid peroxidation via the generation of reactive oxygen species. Currently, there are no other studies regarding the direct effects of propofol medium chain triglyceride/long chain triglyceride (MCT/LCT) on reactive oxygen species generation or in experimental models of reactive oxygen species-induced oxidative stress in the brain.
The authors investigated the effects of propofol MCT/LCT on reactive oxygen species (hydroxyl radical or superoxide) by electron spin resonance spin trapping with 5,5-dimethyl-1-pyrroline-N-oxide. The effects of propofol MCT/LCT on oxidative stress in the brain of Wistar-Kyoto rats or stroke-prone spontaneously hypertensive rats were investigated by using an in vivo L-band electron spin resonance system to monitor the decay rate of 3-methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl as a nitroxyl spin probe.
These studies provided direct evidence that propofol MCT/LCT inhibited hydroxyl radical generation, but not superoxide generation. Regarding the hydroxyl radical from the Fenton system, it is likely to be due to the scavenging effects of vehicle. Anesthesia with propofol MCT/LCT reduced the degree of the high oxidative stress in the brain of stroke-prone spontaneously hypertensive rats.
The current data show that propofol, mixed with clinical reagents (propofol MCT/LCT), resulted in the down-regulation of high oxidative stress due to scavenging hydroxyl radical, as demonstrated by in vitro or in vivo electron spin resonance analysis. These results led to reduced levels of hydroxyl radical, formed by brain injury such as stroke, and may therefore provide advantages for neuroprotection during anesthesia for craniotomy, e.g., in cases of brain disease.</description><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthetics, Intravenous - chemistry</subject><subject>Anesthetics, Intravenous - pharmacology</subject><subject>Animals</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Disease Models, Animal</subject><subject>Electron Spin Resonance Spectroscopy - methods</subject><subject>Hydrogen Peroxide - chemistry</subject><subject>Hydrogen Peroxide - radiation effects</subject><subject>Iron - chemistry</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oxidative Stress - drug effects</subject><subject>Propofol - chemistry</subject><subject>Propofol - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Wistar</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Superoxides - metabolism</subject><subject>Triglycerides - chemistry</subject><subject>Triglycerides - pharmacology</subject><subject>Ultraviolet Rays</subject><issn>0003-3022</issn><issn>1528-1175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdtu1DAQQCMEotvCHyDkF3hL62ucPC7LQpGWi3p5jhxn3BoSO9heRL6zP4T3IpAQEk-WZ86c8XiK4gXB5wQ38kIN7hx3mDBgpCY1VQ1mj4oFEbQuCZHicbHAGLOSYUpPitMYv-arFKx-WpyQWpKGc7woHt7aADqhZYwQ4wguReQNSveAli5Z_9P2yiW0NiZT-9SX4Cdv_IA-Qm-3I1rdK-vQTbB3w6wh2B4uNt7d_SOOvNuL34RdJquuU_DfoJyCd4CuJ--ScuC3cZjR5TxBSOCi_QHoSuXWt9Fm63rI78h8xrPjCqJ3yuld9T4etZ_mZ8UTo4YIz4_nWXH7bn2zuiw3n99_WC03pRaSpbLpu15JKjHpdG1IL6XualqxildGaWWE6IBKRTthuOhFrY2STSUqrGoFtWTsrHh98OYBvm8hpna0UcMwHKZoq4YLUfH_gxQLxjkXGeQHUOdRYgDTTsGOKswtwe1u6-1y86n9e-u57OXRv-1G6P8UHdecgVdHQEWtBhPyn9n4m6O4IhXNol_Ssrvv</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>KOBAYASHI, Kyo</creator><creator>YOSHINO, Fumihiko</creator><creator>TAKAHASHI, Shun-Suke</creator><creator>TODOKI, Kazuo</creator><creator>MAEHATA, Yojiro</creator><creator>KOMATSU, Tomoko</creator><creator>YOSHIDA, Kazu-Lchi</creator><creator>LEE, Masaichi-Chang-Il</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20080901</creationdate><title>Direct Assessments of the Antioxidant Effects of Propofol Medium Chain Triglyceride/Long Chain Triglyceride on the Brain of Stroke-prone Spontaneously Hypertensive Rats Using Electron Spin Resonance Spectroscopy</title><author>KOBAYASHI, Kyo ; YOSHINO, Fumihiko ; TAKAHASHI, Shun-Suke ; TODOKI, Kazuo ; MAEHATA, Yojiro ; KOMATSU, Tomoko ; YOSHIDA, Kazu-Lchi ; LEE, Masaichi-Chang-Il</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-9dbda72701bc8f1d77cb8263646facaf55be27a2b5f45d58cfa796560a8ae8733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthetics, Intravenous - chemistry</topic><topic>Anesthetics, Intravenous - pharmacology</topic><topic>Animals</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Disease Models, Animal</topic><topic>Electron Spin Resonance Spectroscopy - methods</topic><topic>Hydrogen Peroxide - chemistry</topic><topic>Hydrogen Peroxide - radiation effects</topic><topic>Iron - chemistry</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oxidative Stress - drug effects</topic><topic>Propofol - chemistry</topic><topic>Propofol - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Wistar</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Superoxides - metabolism</topic><topic>Triglycerides - chemistry</topic><topic>Triglycerides - pharmacology</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOBAYASHI, Kyo</creatorcontrib><creatorcontrib>YOSHINO, Fumihiko</creatorcontrib><creatorcontrib>TAKAHASHI, Shun-Suke</creatorcontrib><creatorcontrib>TODOKI, Kazuo</creatorcontrib><creatorcontrib>MAEHATA, Yojiro</creatorcontrib><creatorcontrib>KOMATSU, Tomoko</creatorcontrib><creatorcontrib>YOSHIDA, Kazu-Lchi</creatorcontrib><creatorcontrib>LEE, Masaichi-Chang-Il</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesiology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOBAYASHI, Kyo</au><au>YOSHINO, Fumihiko</au><au>TAKAHASHI, Shun-Suke</au><au>TODOKI, Kazuo</au><au>MAEHATA, Yojiro</au><au>KOMATSU, Tomoko</au><au>YOSHIDA, Kazu-Lchi</au><au>LEE, Masaichi-Chang-Il</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Direct Assessments of the Antioxidant Effects of Propofol Medium Chain Triglyceride/Long Chain Triglyceride on the Brain of Stroke-prone Spontaneously Hypertensive Rats Using Electron Spin Resonance Spectroscopy</atitle><jtitle>Anesthesiology (Philadelphia)</jtitle><addtitle>Anesthesiology</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>109</volume><issue>3</issue><spage>426</spage><epage>435</epage><pages>426-435</pages><issn>0003-3022</issn><eissn>1528-1175</eissn><coden>ANESAV</coden><abstract>Antioxidant anesthetics such as propofol (2,6-diisopropylphenol) directly inhibit lipid peroxidation via the generation of reactive oxygen species. Currently, there are no other studies regarding the direct effects of propofol medium chain triglyceride/long chain triglyceride (MCT/LCT) on reactive oxygen species generation or in experimental models of reactive oxygen species-induced oxidative stress in the brain.
The authors investigated the effects of propofol MCT/LCT on reactive oxygen species (hydroxyl radical or superoxide) by electron spin resonance spin trapping with 5,5-dimethyl-1-pyrroline-N-oxide. The effects of propofol MCT/LCT on oxidative stress in the brain of Wistar-Kyoto rats or stroke-prone spontaneously hypertensive rats were investigated by using an in vivo L-band electron spin resonance system to monitor the decay rate of 3-methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl as a nitroxyl spin probe.
These studies provided direct evidence that propofol MCT/LCT inhibited hydroxyl radical generation, but not superoxide generation. Regarding the hydroxyl radical from the Fenton system, it is likely to be due to the scavenging effects of vehicle. Anesthesia with propofol MCT/LCT reduced the degree of the high oxidative stress in the brain of stroke-prone spontaneously hypertensive rats.
The current data show that propofol, mixed with clinical reagents (propofol MCT/LCT), resulted in the down-regulation of high oxidative stress due to scavenging hydroxyl radical, as demonstrated by in vitro or in vivo electron spin resonance analysis. These results led to reduced levels of hydroxyl radical, formed by brain injury such as stroke, and may therefore provide advantages for neuroprotection during anesthesia for craniotomy, e.g., in cases of brain disease.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>18719440</pmid><doi>10.1097/aln.0b013e318182a903</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Anesthesiology (Philadelphia), 2008-09, Vol.109 (3), p.426-435 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Intravenous - chemistry Anesthetics, Intravenous - pharmacology Animals Antioxidants - chemistry Antioxidants - pharmacology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Brain - drug effects Brain - metabolism Cardiology. Vascular system Cerebrovascular Circulation - drug effects Disease Models, Animal Electron Spin Resonance Spectroscopy - methods Hydrogen Peroxide - chemistry Hydrogen Peroxide - radiation effects Iron - chemistry Lipid Peroxidation - drug effects Male Medical sciences Oxidative Stress - drug effects Propofol - chemistry Propofol - pharmacology Rats Rats, Inbred SHR Rats, Wistar Reactive Oxygen Species - metabolism Superoxides - metabolism Triglycerides - chemistry Triglycerides - pharmacology Ultraviolet Rays |
| title | Direct Assessments of the Antioxidant Effects of Propofol Medium Chain Triglyceride/Long Chain Triglyceride on the Brain of Stroke-prone Spontaneously Hypertensive Rats Using Electron Spin Resonance Spectroscopy |
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