Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking

Ataxin-2 is a novel protein, where the unstable expansion of an internal polyglutamine domain can cause the neurodegenerative disease Spinocerebellar Ataxia type 2 (SCA2). To elucidate its cellular function, we have used full-length ataxin-2 as bait in a yeast two-hybrid screen of human adult brain...

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Veröffentlicht in:	Cellular signalling 2008-10, Vol.20 (10), p.1725-1739
Hauptverfasser:	Nonis, David, Schmidt, Mirko H.H., van de Loo, Simone, Eich, Florian, Dikic, Ivan, Nowock, Joachim, Auburger, Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - chemistry Acyltransferases - metabolism Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - metabolism Amino Acid Sequence Animals Ataxin-2 Ataxins Brain - metabolism Catalysis Cbl Cell Line Cell Membrane - enzymology CIN85 Endocytosis Endophilin A Endoplasmic Reticulum - enzymology Humans Mice Molecular Sequence Data Neoplasm Proteins - metabolism Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - metabolism Proline - metabolism Protein Binding Protein Structure, Tertiary Protein Transport Proto-Oncogene Proteins c-cbl - metabolism Receptor endocytosis Receptor, Epidermal Growth Factor - metabolism Src
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