Inhibition of Plasminogen Activator Inhibitor-1 by 11-Keto-9(E), 12(E)-octadecadienoic Acid, a Novel Fatty Acid Produced by Trichoderma sp
We have recently found a novel fatty acid, 11-keto-9(E), 12(E)-octadecadienoic acid (KOD), that enhances fibrinolytic activity of endothelial cells. The mechanism of action of KOD has been investigated. KOD increased 2-fold the plasmin activity of bovine aortic endothelial cells at 250 μM. The stimu...
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| Veröffentlicht in: | Journal of antibiotics 1999/09/25, Vol.52(9), pp.797-802 |
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| container_title | Journal of antibiotics |
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| creator | CHIKANISHI, TOSHIHIRO SHINOHARA, CHIKARA KIKUCHI, TADASHI ENDO, AKIRA HASUMI, KEIJI |
| description | We have recently found a novel fatty acid, 11-keto-9(E), 12(E)-octadecadienoic acid (KOD), that enhances fibrinolytic activity of endothelial cells. The mechanism of action of KOD has been investigated. KOD increased 2-fold the plasmin activity of bovine aortic endothelial cells at 250 μM. The stimulation was dependent on plasminogen and was inhibited by anti-urokinase, whereas KOD did not enhance the urokinase-catalyzed plasminogen activation and the resulting plasmin activity in a cell-free system. Neither the production of urokinase nor the conversion of pro-urokinase to the active, two-chain form was elevated by KOD, but it decreased plasminogen activator inhibitor-1 (PAI-1) activity of cells and inactivated PAI-1 irreversibly in a purified system. These results demonstrated that the KOD enhancement of endothelial fibrinolytic activity was mediated, at least in part, by inactivation of PAI-1. |
| doi_str_mv | 10.7164/antibiotics.52.797 |
| format | Article |
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The mechanism of action of KOD has been investigated. KOD increased 2-fold the plasmin activity of bovine aortic endothelial cells at 250 μM. The stimulation was dependent on plasminogen and was inhibited by anti-urokinase, whereas KOD did not enhance the urokinase-catalyzed plasminogen activation and the resulting plasmin activity in a cell-free system. Neither the production of urokinase nor the conversion of pro-urokinase to the active, two-chain form was elevated by KOD, but it decreased plasminogen activator inhibitor-1 (PAI-1) activity of cells and inactivated PAI-1 irreversibly in a purified system. These results demonstrated that the KOD enhancement of endothelial fibrinolytic activity was mediated, at least in part, by inactivation of PAI-1.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.52.797</identifier><identifier>PMID: 10726927</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>11-Keto-9(E),12(E)-octadecadienoic acid ; Animals ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Cattle ; Cells, Cultured ; Endothelium, Vascular - drug effects ; Fatty Acids - pharmacology ; Fibrinolysis - drug effects ; Humans ; Linoleic Acids - pharmacology ; Medical sciences ; Pharmacology. Drug treatments ; plasminogen activator inhibitor 1 ; Plasminogen Activator Inhibitor 1 - metabolism ; Trichoderma ; Trichoderma - metabolism ; u-plasminogen activator inhibitor 1 ; Urokinase-Type Plasminogen Activator - metabolism</subject><ispartof>The Journal of Antibiotics, 1999/09/25, Vol.52(9), pp.797-802</ispartof><rights>Japan Antibiotics Research Association</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c667t-857502d334ae54d2531c9aba3d77a9e59efda14cf8f1a55a65879cc25ce0454b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1208805$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10726927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHIKANISHI, TOSHIHIRO</creatorcontrib><creatorcontrib>SHINOHARA, CHIKARA</creatorcontrib><creatorcontrib>KIKUCHI, TADASHI</creatorcontrib><creatorcontrib>ENDO, AKIRA</creatorcontrib><creatorcontrib>HASUMI, KEIJI</creatorcontrib><title>Inhibition of Plasminogen Activator Inhibitor-1 by 11-Keto-9(E), 12(E)-octadecadienoic Acid, a Novel Fatty Acid Produced by Trichoderma sp</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>We have recently found a novel fatty acid, 11-keto-9(E), 12(E)-octadecadienoic acid (KOD), that enhances fibrinolytic activity of endothelial cells. The mechanism of action of KOD has been investigated. KOD increased 2-fold the plasmin activity of bovine aortic endothelial cells at 250 μM. The stimulation was dependent on plasminogen and was inhibited by anti-urokinase, whereas KOD did not enhance the urokinase-catalyzed plasminogen activation and the resulting plasmin activity in a cell-free system. Neither the production of urokinase nor the conversion of pro-urokinase to the active, two-chain form was elevated by KOD, but it decreased plasminogen activator inhibitor-1 (PAI-1) activity of cells and inactivated PAI-1 irreversibly in a purified system. These results demonstrated that the KOD enhancement of endothelial fibrinolytic activity was mediated, at least in part, by inactivation of PAI-1.</description><subject>11-Keto-9(E),12(E)-octadecadienoic acid</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Cattle</subject><subject>Cells, Cultured</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Fatty Acids - pharmacology</subject><subject>Fibrinolysis - drug effects</subject><subject>Humans</subject><subject>Linoleic Acids - pharmacology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>plasminogen activator inhibitor 1</subject><subject>Plasminogen Activator Inhibitor 1 - metabolism</subject><subject>Trichoderma</subject><subject>Trichoderma - metabolism</subject><subject>u-plasminogen activator inhibitor 1</subject><subject>Urokinase-Type Plasminogen Activator - metabolism</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EokvhD3BAPqAKpGaxnTi2j1XV0qoV9FDO0cSedF0l8WJ7K-1f4FeTJat2b1xmpPH33rP0CPnI2VLxuvoGY_atD9nbtJRiqYx6RRZca17wqjavyYIxwQutBTsi71J6ZKxUpdJvyRFnStRGqAX5cz2uJpPsw0hDR-96SIMfwwOO9Mxm_wQ5RLpnQiw4bbeU8-IGcyjMl4uvp5SLaRXBZnBowXkcg7eT2LtTCvRHeMKeXkLO2383eheD21h0O6P76O0qOIwD0LR-T9500Cf8sN_H5Nflxf35VXH78_v1-dltYeta5UJLJZlwZVkBysoJWXJroIXSKQUGpcHOAa9spzsOUkIttTLWCmmRVbJqy2NyMvuuY_i9wZSbwSeLfQ8jhk1qalNJoWvzX5CrSvLS7EAxgzaGlCJ2zTr6AeK24azZVdUcVNVI0UxVTaJPe_dNO6A7kMzdTMDnPQDJQt9FGK1PL5xgWjM5YTcz9pgyPODzO8QprcfDaG5qvYs385h-8UzZFcQGx_Ivq4a5fA</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>CHIKANISHI, TOSHIHIRO</creator><creator>SHINOHARA, CHIKARA</creator><creator>KIKUCHI, TADASHI</creator><creator>ENDO, AKIRA</creator><creator>HASUMI, KEIJI</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Inhibition of Plasminogen Activator Inhibitor-1 by 11-Keto-9(E), 12(E)-octadecadienoic Acid, a Novel Fatty Acid Produced by Trichoderma sp</title><author>CHIKANISHI, TOSHIHIRO ; SHINOHARA, CHIKARA ; KIKUCHI, TADASHI ; ENDO, AKIRA ; HASUMI, KEIJI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c667t-857502d334ae54d2531c9aba3d77a9e59efda14cf8f1a55a65879cc25ce0454b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>11-Keto-9(E),12(E)-octadecadienoic acid</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Cattle</topic><topic>Cells, Cultured</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Fatty Acids - pharmacology</topic><topic>Fibrinolysis - drug effects</topic><topic>Humans</topic><topic>Linoleic Acids - pharmacology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>plasminogen activator inhibitor 1</topic><topic>Plasminogen Activator Inhibitor 1 - metabolism</topic><topic>Trichoderma</topic><topic>Trichoderma - metabolism</topic><topic>u-plasminogen activator inhibitor 1</topic><topic>Urokinase-Type Plasminogen Activator - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHIKANISHI, TOSHIHIRO</creatorcontrib><creatorcontrib>SHINOHARA, CHIKARA</creatorcontrib><creatorcontrib>KIKUCHI, TADASHI</creatorcontrib><creatorcontrib>ENDO, AKIRA</creatorcontrib><creatorcontrib>HASUMI, KEIJI</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHIKANISHI, TOSHIHIRO</au><au>SHINOHARA, CHIKARA</au><au>KIKUCHI, TADASHI</au><au>ENDO, AKIRA</au><au>HASUMI, KEIJI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Plasminogen Activator Inhibitor-1 by 11-Keto-9(E), 12(E)-octadecadienoic Acid, a Novel Fatty Acid Produced by Trichoderma sp</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1999</date><risdate>1999</risdate><volume>52</volume><issue>9</issue><spage>797</spage><epage>802</epage><pages>797-802</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>We have recently found a novel fatty acid, 11-keto-9(E), 12(E)-octadecadienoic acid (KOD), that enhances fibrinolytic activity of endothelial cells. The mechanism of action of KOD has been investigated. KOD increased 2-fold the plasmin activity of bovine aortic endothelial cells at 250 μM. The stimulation was dependent on plasminogen and was inhibited by anti-urokinase, whereas KOD did not enhance the urokinase-catalyzed plasminogen activation and the resulting plasmin activity in a cell-free system. Neither the production of urokinase nor the conversion of pro-urokinase to the active, two-chain form was elevated by KOD, but it decreased plasminogen activator inhibitor-1 (PAI-1) activity of cells and inactivated PAI-1 irreversibly in a purified system. 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| subjects | 11-Keto-9(E),12(E)-octadecadienoic acid Animals Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Cattle Cells, Cultured Endothelium, Vascular - drug effects Fatty Acids - pharmacology Fibrinolysis - drug effects Humans Linoleic Acids - pharmacology Medical sciences Pharmacology. Drug treatments plasminogen activator inhibitor 1 Plasminogen Activator Inhibitor 1 - metabolism Trichoderma Trichoderma - metabolism u-plasminogen activator inhibitor 1 Urokinase-Type Plasminogen Activator - metabolism |
| title | Inhibition of Plasminogen Activator Inhibitor-1 by 11-Keto-9(E), 12(E)-octadecadienoic Acid, a Novel Fatty Acid Produced by Trichoderma sp |
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