Stromal cells play a role in cervical cancer progression mediated by MMP-2 protein
Metalloproteinases, especially metalloproteinase-2 (MMP-2), are known for their role in the degradation of the extracellular matrix. Nevertheless, a thorough understanding of MMP-2 expression in neoplastic lesions of the uterine cervix has yet to be accomplished. This study aimed to analyze the MMP-...
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| Veröffentlicht in: | European journal of gynaecological oncology 2008, Vol.29 (4), p.341-344 |
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| container_title | European journal of gynaecological oncology |
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| creator | Fernandes, T de Angelo-Andrade, L A Morais, S S Pinto, G A Chagas, C A Maria-Engler, S S Zeferino, L C |
| description | Metalloproteinases, especially metalloproteinase-2 (MMP-2), are known for their role in the degradation of the extracellular matrix. Nevertheless, a thorough understanding of MMP-2 expression in neoplastic lesions of the uterine cervix has yet to be accomplished. This study aimed to analyze the MMP-2 expression in cervical intraepithelial neoplasia III (CIN3) and in cervical squamous cell carcinoma, in tumor cells and adjacent stromal cells. MMP-2 expression was assessed by an immunohistochemical technique. MMP-2 expression was greater in the stromal cells of invasive carcinomas than in CIN3 (p < 0.0001). MMP-2 expression in stromal cells correlates with the clinical stage, gradually increasing as the tumor progresses (p = 0.04). This study corroborates that stromal cells play an important role in tumor invasion and progression, mediated by the progressive enhancement of MMP-2 expression from CIN3 to advanced invasive tumor. The intense MMP-2 expression most probably is associated with poor tumor prognosis. |
| format | Article |
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Nevertheless, a thorough understanding of MMP-2 expression in neoplastic lesions of the uterine cervix has yet to be accomplished. This study aimed to analyze the MMP-2 expression in cervical intraepithelial neoplasia III (CIN3) and in cervical squamous cell carcinoma, in tumor cells and adjacent stromal cells. MMP-2 expression was assessed by an immunohistochemical technique. MMP-2 expression was greater in the stromal cells of invasive carcinomas than in CIN3 (p < 0.0001). MMP-2 expression in stromal cells correlates with the clinical stage, gradually increasing as the tumor progresses (p = 0.04). This study corroborates that stromal cells play an important role in tumor invasion and progression, mediated by the progressive enhancement of MMP-2 expression from CIN3 to advanced invasive tumor. The intense MMP-2 expression most probably is associated with poor tumor prognosis.</description><identifier>ISSN: 0392-2936</identifier><identifier>PMID: 18714566</identifier><language>eng</language><publisher>Italy</publisher><subject>Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Cervical Intraepithelial Neoplasia - metabolism ; Cervical Intraepithelial Neoplasia - pathology ; Cervix Uteri - metabolism ; Cervix Uteri - pathology ; Disease Progression ; Female ; Humans ; Immunohistochemistry ; Matrix Metalloproteinase 2 - biosynthesis ; Matrix Metalloproteinase 2 - genetics ; Neoplasm Invasiveness - genetics ; Stromal Cells - metabolism ; Stromal Cells - pathology ; Tissue Inhibitor of Metalloproteinase-2 - biosynthesis ; Tissue Inhibitor of Metalloproteinase-2 - genetics ; Uterine Cervical Neoplasms - metabolism ; Uterine Cervical Neoplasms - pathology</subject><ispartof>European journal of gynaecological oncology, 2008, Vol.29 (4), p.341-344</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18714566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernandes, T</creatorcontrib><creatorcontrib>de Angelo-Andrade, L A</creatorcontrib><creatorcontrib>Morais, S S</creatorcontrib><creatorcontrib>Pinto, G A</creatorcontrib><creatorcontrib>Chagas, C A</creatorcontrib><creatorcontrib>Maria-Engler, S S</creatorcontrib><creatorcontrib>Zeferino, L C</creatorcontrib><title>Stromal cells play a role in cervical cancer progression mediated by MMP-2 protein</title><title>European journal of gynaecological oncology</title><addtitle>Eur J Gynaecol Oncol</addtitle><description>Metalloproteinases, especially metalloproteinase-2 (MMP-2), are known for their role in the degradation of the extracellular matrix. Nevertheless, a thorough understanding of MMP-2 expression in neoplastic lesions of the uterine cervix has yet to be accomplished. This study aimed to analyze the MMP-2 expression in cervical intraepithelial neoplasia III (CIN3) and in cervical squamous cell carcinoma, in tumor cells and adjacent stromal cells. MMP-2 expression was assessed by an immunohistochemical technique. MMP-2 expression was greater in the stromal cells of invasive carcinomas than in CIN3 (p < 0.0001). MMP-2 expression in stromal cells correlates with the clinical stage, gradually increasing as the tumor progresses (p = 0.04). This study corroborates that stromal cells play an important role in tumor invasion and progression, mediated by the progressive enhancement of MMP-2 expression from CIN3 to advanced invasive tumor. The intense MMP-2 expression most probably is associated with poor tumor prognosis.</description><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cervical Intraepithelial Neoplasia - metabolism</subject><subject>Cervical Intraepithelial Neoplasia - pathology</subject><subject>Cervix Uteri - metabolism</subject><subject>Cervix Uteri - pathology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Matrix Metalloproteinase 2 - biosynthesis</subject><subject>Matrix Metalloproteinase 2 - genetics</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Stromal Cells - metabolism</subject><subject>Stromal Cells - pathology</subject><subject>Tissue Inhibitor of Metalloproteinase-2 - biosynthesis</subject><subject>Tissue Inhibitor of Metalloproteinase-2 - genetics</subject><subject>Uterine Cervical Neoplasms - metabolism</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>0392-2936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UMtOwzAQ9AFES-EXkE_cIjl-JT6iipfUCgS9R-tHkZHzwE6Q8vc4ajntaGe0OzMXaE2YogVVTK7QdUrfhHBeSXqFVmVdlVxIuUYfn2PsWwjYuBASHgLMGHDsg8O-y8v4683CQpcxHmL_FV1Kvu9w66yH0VmsZ7zfvxd0YUfnuxt0eYSQ3O15btDh6fGwfSl2b8-v24ddMVCixoIZ4HB0AqSxSpuyqkBond0ywqSTIFhttGJQ1lxWtVQErKppSQW3llnFNuj-dDa__ZlcGpvWpyUFdK6fUiMVF5RSloV3Z-Gks-lmiL6FODf_JbA_yb1XIg</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Fernandes, T</creator><creator>de Angelo-Andrade, L A</creator><creator>Morais, S S</creator><creator>Pinto, G A</creator><creator>Chagas, C A</creator><creator>Maria-Engler, S S</creator><creator>Zeferino, L C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Stromal cells play a role in cervical cancer progression mediated by MMP-2 protein</title><author>Fernandes, T ; de Angelo-Andrade, L A ; Morais, S S ; Pinto, G A ; Chagas, C A ; Maria-Engler, S S ; Zeferino, L C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-3ca4afe5a6cd9bc177a5bb2933036e6a538cb93a184678690ad9821254dd3d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cervical Intraepithelial Neoplasia - metabolism</topic><topic>Cervical Intraepithelial Neoplasia - pathology</topic><topic>Cervix Uteri - metabolism</topic><topic>Cervix Uteri - pathology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Matrix Metalloproteinase 2 - biosynthesis</topic><topic>Matrix Metalloproteinase 2 - genetics</topic><topic>Neoplasm Invasiveness - genetics</topic><topic>Stromal Cells - metabolism</topic><topic>Stromal Cells - pathology</topic><topic>Tissue Inhibitor of Metalloproteinase-2 - biosynthesis</topic><topic>Tissue Inhibitor of Metalloproteinase-2 - genetics</topic><topic>Uterine Cervical Neoplasms - metabolism</topic><topic>Uterine Cervical Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernandes, T</creatorcontrib><creatorcontrib>de Angelo-Andrade, L A</creatorcontrib><creatorcontrib>Morais, S S</creatorcontrib><creatorcontrib>Pinto, G A</creatorcontrib><creatorcontrib>Chagas, C A</creatorcontrib><creatorcontrib>Maria-Engler, S S</creatorcontrib><creatorcontrib>Zeferino, L C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gynaecological oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernandes, T</au><au>de Angelo-Andrade, L A</au><au>Morais, S S</au><au>Pinto, G A</au><au>Chagas, C A</au><au>Maria-Engler, S S</au><au>Zeferino, L C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stromal cells play a role in cervical cancer progression mediated by MMP-2 protein</atitle><jtitle>European journal of gynaecological oncology</jtitle><addtitle>Eur J Gynaecol Oncol</addtitle><date>2008</date><risdate>2008</risdate><volume>29</volume><issue>4</issue><spage>341</spage><epage>344</epage><pages>341-344</pages><issn>0392-2936</issn><abstract>Metalloproteinases, especially metalloproteinase-2 (MMP-2), are known for their role in the degradation of the extracellular matrix. 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| subjects | Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cervical Intraepithelial Neoplasia - metabolism Cervical Intraepithelial Neoplasia - pathology Cervix Uteri - metabolism Cervix Uteri - pathology Disease Progression Female Humans Immunohistochemistry Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 2 - genetics Neoplasm Invasiveness - genetics Stromal Cells - metabolism Stromal Cells - pathology Tissue Inhibitor of Metalloproteinase-2 - biosynthesis Tissue Inhibitor of Metalloproteinase-2 - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology |
| title | Stromal cells play a role in cervical cancer progression mediated by MMP-2 protein |
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