Alpha1-adrenergic receptor mRNA and inflammatory mediator expression in circulating leucocytes after cardiac surgery

Vasodilation after coronary artery bypass surgery is a common complication. Inflammatory mediators influence the expression of alpha1-adrenergic receptors. Do patients requiring high doses of postoperative inotropic support have down-regulated alpha-adrenergic receptors? Is there a characteristic pa...

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Veröffentlicht in:	Anaesthesia and intensive care 2008-07, Vol.36 (4), p.535-543
Hauptverfasser:	Kalkoff, M, Chan-Dominy, A, Sleigh, J W, Jogia, P M, Cursons, R T, Towers, R, La Pine, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - blood Adrenergic alpha-Agonists - therapeutic use Aged Blood vessels Coronary Artery Bypass Cytokines - blood Cytokines - drug effects Cytokines - genetics Dilatation Dose-Response Relationship, Drug Epinephrine Female Gene Expression Genetic aspects Health aspects Humans Inflammation - blood Leukocytes Leukocytes - metabolism Male Middle Aged Norepinephrine - blood Norepinephrine - therapeutic use Postoperative Period Prospective Studies Receptors Receptors, Adrenergic, alpha - blood Receptors, Adrenergic, alpha - drug effects Receptors, Adrenergic, alpha - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Time Factors Treatment Outcome
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