Amoxicillin sodium–potassium clavulanate: evaluation of gamma radiation induced effects by liquid chromatography on both the individual drugs and their combination

The effects of gamma irradiation on the stability of potassium clavulanate, amoxicillin sodium and their combination were investigated. A decrease in purity and increase in degradation products up to 30 days after the irradiation were evaluated by reversed phase HPLC. The comparison between unirradi...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1999-10, Vol.21 (1), p.9-14
Hauptverfasser:	Valvo, L, Manna, L, Alimenti, R, Alimonti, S, Bertocchi, P, Ciranni, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amoxicillin - analysis Amoxicillin - radiation effects Amoxicillin sodium Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Chromatography, High Pressure Liquid - methods Clavulanic Acid - analysis Clavulanic Acid - radiation effects Degradation Drug Combinations Drug Stability Evaluation Studies as Topic Gamma irradiation Gamma Rays General pharmacology Medical sciences Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Potassium clavulanate Reversed-phase HPLC Sterilization
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