Simultaneous multivariate spectrophotometric analysis of paracetamol and minor components (diphenhydramine or phenylpropanolamine) in tablet preparations
The use of multivariate spectrophotometric calibration is reported for the analysis of two decongestant tablets, where paracetamol is the principal component and diphenhydramine or phenylpropanolamine are the minor components. The resolution of these mixtures has been accomplished without prior sepa...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 1999-06, Vol.20 (1), p.255-261 |
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| creator | Goicoechea, Héctor C. Olivieri, Alejandro C. |
| description | The use of multivariate spectrophotometric calibration is reported for the analysis of two decongestant tablets, where paracetamol is the principal component and diphenhydramine or phenylpropanolamine are the minor components. The resolution of these mixtures has been accomplished without prior separation or derivatisation, by using partial least-squares (PLS-1) regression analysis of electronic absorption spectral data. Although the molar ratios of paracetamol to the minor components were 38:1 and 25:1 respectively, the latter have been determined with high accuracy and precision, and with no interference from tablet excipients. PLS is able to take into account small deviations of paracetamol from linearity in the studied concentration range. The application of classical least-squares (CLS) analysis yields unsatisfactory results, due to the low absorbances of the minor components within the range where all components obey Beer’s law. |
| doi_str_mv | 10.1016/S0731-7085(99)00029-1 |
| format | Article |
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The resolution of these mixtures has been accomplished without prior separation or derivatisation, by using partial least-squares (PLS-1) regression analysis of electronic absorption spectral data. Although the molar ratios of paracetamol to the minor components were 38:1 and 25:1 respectively, the latter have been determined with high accuracy and precision, and with no interference from tablet excipients. PLS is able to take into account small deviations of paracetamol from linearity in the studied concentration range. 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Drug treatments ; Phenylpropanolamine ; Phenylpropanolamine - analysis ; Spectrophotometry, Ultraviolet ; Tablets</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 1999-06, Vol.20 (1), p.255-261</ispartof><rights>1999 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-25bb22141763976b57a82415c651d7f50c83078a3f1cbe4e6250f118154c84a23</citedby><cites>FETCH-LOGICAL-c456t-25bb22141763976b57a82415c651d7f50c83078a3f1cbe4e6250f118154c84a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0731-7085(99)00029-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1774210$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10704030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goicoechea, Héctor C.</creatorcontrib><creatorcontrib>Olivieri, Alejandro C.</creatorcontrib><title>Simultaneous multivariate spectrophotometric analysis of paracetamol and minor components (diphenhydramine or phenylpropanolamine) in tablet preparations</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>The use of multivariate spectrophotometric calibration is reported for the analysis of two decongestant tablets, where paracetamol is the principal component and diphenhydramine or phenylpropanolamine are the minor components. The resolution of these mixtures has been accomplished without prior separation or derivatisation, by using partial least-squares (PLS-1) regression analysis of electronic absorption spectral data. Although the molar ratios of paracetamol to the minor components were 38:1 and 25:1 respectively, the latter have been determined with high accuracy and precision, and with no interference from tablet excipients. PLS is able to take into account small deviations of paracetamol from linearity in the studied concentration range. The application of classical least-squares (CLS) analysis yields unsatisfactory results, due to the low absorbances of the minor components within the range where all components obey Beer’s law.</description><subject>Acetaminophen - analysis</subject><subject>Algorithms</subject><subject>Analgesics, Non-Narcotic - analysis</subject><subject>Analysis</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Calibration</subject><subject>Decongestant tablets</subject><subject>Diphenhydramine - analysis</subject><subject>Diphenydramine</subject><subject>Drug Combinations</subject><subject>Electronic absorption</subject><subject>General pharmacology</subject><subject>Histamine H1 Antagonists - analysis</subject><subject>Indicators and Reagents</subject><subject>Least-Squares Analysis</subject><subject>Medical sciences</subject><subject>Multivariate PLS analysis</subject><subject>Nasal Decongestants - analysis</subject><subject>Paracetamol</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenylpropanolamine</subject><subject>Phenylpropanolamine - analysis</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Tablets</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2L1TAUhoMoznX0JyhZiMwsqkmbNO1KZPALBlyMgrtwmp5yI2lSk9yB-1P8t6a3F3XnKuE9z_ngfQl5ztlrznj75o6phleKdfKq768ZY3Vf8QdkxzvVVHUrvj8kuz_IBXmS0o8CSd6Lx-SCM8UEa9iO_Lqz88Fl8BgOia5few_RQkaaFjQ5hmUfcpgxR2soeHDHZBMNE10ggsEMc3BFH-lsfYjUhHkJHn1O9Gq0yx79_jhGKEWkpbwKR7eUqeCDO8nX1HqaYXCY6RJxHZtt8OkpeTSBS_js_F6Sbx_ef735VN1--fj55t1tZYRsc1XLYahrLrhqm161g1TQ1YJL00o-qkky0zVMddBM3AwosK0lmzjvuBSmE1A3l-TVNrdc9fOAKevZJoPObZ7otheiK34VUG6giSGliJNeop0hHjVnes1EnzLRq-G67_UpE81L34vzgsMw4_hP1xZCAV6eAUgG3BTBG5v-ckqJmq_Y2w3D4sa9xaiTsegNjjaWpPQY7H8u-Q3zYKym</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>Goicoechea, Héctor C.</creator><creator>Olivieri, Alejandro C.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990601</creationdate><title>Simultaneous multivariate spectrophotometric analysis of paracetamol and minor components (diphenhydramine or phenylpropanolamine) in tablet preparations</title><author>Goicoechea, Héctor C. ; Olivieri, Alejandro C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-25bb22141763976b57a82415c651d7f50c83078a3f1cbe4e6250f118154c84a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acetaminophen - analysis</topic><topic>Algorithms</topic><topic>Analgesics, Non-Narcotic - analysis</topic><topic>Analysis</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Calibration</topic><topic>Decongestant tablets</topic><topic>Diphenhydramine - analysis</topic><topic>Diphenydramine</topic><topic>Drug Combinations</topic><topic>Electronic absorption</topic><topic>General pharmacology</topic><topic>Histamine H1 Antagonists - analysis</topic><topic>Indicators and Reagents</topic><topic>Least-Squares Analysis</topic><topic>Medical sciences</topic><topic>Multivariate PLS analysis</topic><topic>Nasal Decongestants - analysis</topic><topic>Paracetamol</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenylpropanolamine</topic><topic>Phenylpropanolamine - analysis</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Tablets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goicoechea, Héctor C.</creatorcontrib><creatorcontrib>Olivieri, Alejandro C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goicoechea, Héctor C.</au><au>Olivieri, Alejandro C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous multivariate spectrophotometric analysis of paracetamol and minor components (diphenhydramine or phenylpropanolamine) in tablet preparations</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>20</volume><issue>1</issue><spage>255</spage><epage>261</epage><pages>255-261</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>The use of multivariate spectrophotometric calibration is reported for the analysis of two decongestant tablets, where paracetamol is the principal component and diphenhydramine or phenylpropanolamine are the minor components. The resolution of these mixtures has been accomplished without prior separation or derivatisation, by using partial least-squares (PLS-1) regression analysis of electronic absorption spectral data. Although the molar ratios of paracetamol to the minor components were 38:1 and 25:1 respectively, the latter have been determined with high accuracy and precision, and with no interference from tablet excipients. PLS is able to take into account small deviations of paracetamol from linearity in the studied concentration range. The application of classical least-squares (CLS) analysis yields unsatisfactory results, due to the low absorbances of the minor components within the range where all components obey Beer’s law.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>10704030</pmid><doi>10.1016/S0731-7085(99)00029-1</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 1999-06, Vol.20 (1), p.255-261 |
| issn | 0731-7085 1873-264X |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acetaminophen - analysis Algorithms Analgesics, Non-Narcotic - analysis Analysis Analysis of Variance Biological and medical sciences Calibration Decongestant tablets Diphenhydramine - analysis Diphenydramine Drug Combinations Electronic absorption General pharmacology Histamine H1 Antagonists - analysis Indicators and Reagents Least-Squares Analysis Medical sciences Multivariate PLS analysis Nasal Decongestants - analysis Paracetamol Pharmacology. Drug treatments Phenylpropanolamine Phenylpropanolamine - analysis Spectrophotometry, Ultraviolet Tablets |
| title | Simultaneous multivariate spectrophotometric analysis of paracetamol and minor components (diphenhydramine or phenylpropanolamine) in tablet preparations |
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