Identification of losartan degradates in stressed tablets by LC-MS and LC-MS/MS

Three unknown peaks were observed in the severely stressed losartan tablets (at 40°C and 75% relative humidity for 3 years) analyzed by a stability indicating HPLC method. The sample solutions were subjected to liquid chromatography-tandem mass spectrometric (LC-MS/MS) analysis to obtain the chemica...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1999-06, Vol.20 (1), p.129-136
Hauptverfasser:	Zhao, Zhongxi (Zack), Wang, Qingxi, Tsai, Eric W, Qin, Xue-Zhi, Ip, Dominic
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Analysis Antihypertensive Agents - analysis Biological and medical sciences Catalysis Chromatography, High Pressure Liquid Degradate identification Degradation pathway Drug Stability Gas Chromatography-Mass Spectrometry General pharmacology HPLC-MS/MS Kinetics Losartan - analysis Losartan potassium Mass Spectrometry Medical sciences Pharmacology. Drug treatments Spectrophotometry, Ultraviolet Tablets
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