Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice

In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-08, Vol.105 (33), p.12028-12033
Hauptverfasser:	Ghosh, Manik C, Tong, Wing-Hang, Zhang, Deliang, Ollivierre-Wilson, Hayden, Singh, Anamika, Krishna, Murali C, Mitchell, James B, Rouault, Tracey A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Biological Sciences Brain Cell Line Cell lines Cells Cyclic N-Oxides - chemistry Cyclic N-Oxides - pharmacology Diet Disease Progression Enzyme Activation Erythroblasts Ferritins Genes Homeostasis Humans Iron Iron Regulatory Protein 1 - metabolism Iron Regulatory Protein 2 - deficiency Iron Regulatory Protein 2 - genetics Iron Regulatory Protein 2 - metabolism Iron regulatory proteins Metabolism Mice Mice, Knockout Molecular Structure Neurodegenerative diseases Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurodegenerative Diseases - prevention & control Neurological disorders Protein Binding Proteins Receptors, Transferrin - metabolism Rodents Spin Labels Wild animals
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