Risk factors for multidrug-resistant tuberculosis in Hong Kong
SETTING: Previous anti-tuberculosis treatment is a widely reported risk factor for multidrug-resistant tuberculosis (MDR-TB), whereas other risk factors are less well described. In Hong Kong, the clinical characteristics of MDR-TB have not been systematically evaluated.OBJECTIVE: To explore the risk...
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| Veröffentlicht in: | The international journal of tuberculosis and lung disease 2008-09, Vol.12 (9), p.1065-1070 |
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| container_title | The international journal of tuberculosis and lung disease |
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| creator | LAW, W. S YEW, W. W CHIU LEUNG, C KAM, K. M TAM, C. M CHAN, C. K LEUNG, C. C |
| description | SETTING: Previous anti-tuberculosis treatment is a widely reported risk factor for multidrug-resistant tuberculosis (MDR-TB), whereas other risk factors are less well described. In Hong Kong, the clinical characteristics of MDR-TB have not been systematically evaluated.OBJECTIVE:
To explore the risk factors for MDR-TB in Hong Kong.DESIGN: MDR-TB patients treated between 1999 and 2003 were compared with non-MDR-TB patients by stratification of previous anti-tuberculosis treatment.RESULTS: One hundred and fifty-six MDR-TB patients, including 93 with and 63 without
a previous history of anti-tuberculosis treatment, were identified. Among the 322 non-MDR-TB controls, respectively 192 and 130 patients did and did not have a previous history of anti-tuberculosis treatment. Using logistic regression analysis, non-permanent residents (OR 6.85, 95%CI 1.38-34.09),
frequent travel (OR 2.48, 95%CI 1.07-5.74) and younger age were found to be independent predictors of MDR-TB in previously treated patients, whereas living on financial assistance just failed to reach statistical significance (OR 2.75, 95%CI 0.98-7.68, P = 0.05).
In the treatment-naïve group, despite significant differences in baseline characteristics among MDR-TB and non-MDR-TB patients, no independent predictor variables could be identified.CONCLUSION: In Hong Kong, non-permanent residents, frequent travel and young age were independent
predictors of MDR-TB among previously treated patients. |
| format | Article |
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To explore the risk factors for MDR-TB in Hong Kong.DESIGN: MDR-TB patients treated between 1999 and 2003 were compared with non-MDR-TB patients by stratification of previous anti-tuberculosis treatment.RESULTS: One hundred and fifty-six MDR-TB patients, including 93 with and 63 without
a previous history of anti-tuberculosis treatment, were identified. Among the 322 non-MDR-TB controls, respectively 192 and 130 patients did and did not have a previous history of anti-tuberculosis treatment. Using logistic regression analysis, non-permanent residents (OR 6.85, 95%CI 1.38-34.09),
frequent travel (OR 2.48, 95%CI 1.07-5.74) and younger age were found to be independent predictors of MDR-TB in previously treated patients, whereas living on financial assistance just failed to reach statistical significance (OR 2.75, 95%CI 0.98-7.68, P = 0.05).
In the treatment-naïve group, despite significant differences in baseline characteristics among MDR-TB and non-MDR-TB patients, no independent predictor variables could be identified.CONCLUSION: In Hong Kong, non-permanent residents, frequent travel and young age were independent
predictors of MDR-TB among previously treated patients.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>PMID: 18713506</identifier><language>eng</language><publisher>Paris, France: IUATLD</publisher><subject>Adult ; Aged ; Antitubercular Agents - therapeutic use ; Bacterial diseases ; Biological and medical sciences ; Case-Control Studies ; Confidence Intervals ; Emigration and Immigration ; Female ; Hong Kong ; Hong Kong - epidemiology ; Human bacterial diseases ; Humans ; Infectious diseases ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Multidrug-Resistant ; Mycobacterium ; Odds Ratio ; Pneumology ; Prevalence ; Prevention and actions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Registries ; Risk Factors ; Tuberculosis ; Tuberculosis - drug therapy ; Tuberculosis - epidemiology ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Multidrug-Resistant - epidemiology</subject><ispartof>The international journal of tuberculosis and lung disease, 2008-09, Vol.12 (9), p.1065-1070</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20602945$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18713506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LAW, W. S</creatorcontrib><creatorcontrib>YEW, W. W</creatorcontrib><creatorcontrib>CHIU LEUNG, C</creatorcontrib><creatorcontrib>KAM, K. M</creatorcontrib><creatorcontrib>TAM, C. M</creatorcontrib><creatorcontrib>CHAN, C. K</creatorcontrib><creatorcontrib>LEUNG, C. C</creatorcontrib><title>Risk factors for multidrug-resistant tuberculosis in Hong Kong</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>SETTING: Previous anti-tuberculosis treatment is a widely reported risk factor for multidrug-resistant tuberculosis (MDR-TB), whereas other risk factors are less well described. In Hong Kong, the clinical characteristics of MDR-TB have not been systematically evaluated.OBJECTIVE:
To explore the risk factors for MDR-TB in Hong Kong.DESIGN: MDR-TB patients treated between 1999 and 2003 were compared with non-MDR-TB patients by stratification of previous anti-tuberculosis treatment.RESULTS: One hundred and fifty-six MDR-TB patients, including 93 with and 63 without
a previous history of anti-tuberculosis treatment, were identified. Among the 322 non-MDR-TB controls, respectively 192 and 130 patients did and did not have a previous history of anti-tuberculosis treatment. Using logistic regression analysis, non-permanent residents (OR 6.85, 95%CI 1.38-34.09),
frequent travel (OR 2.48, 95%CI 1.07-5.74) and younger age were found to be independent predictors of MDR-TB in previously treated patients, whereas living on financial assistance just failed to reach statistical significance (OR 2.75, 95%CI 0.98-7.68, P = 0.05).
In the treatment-naïve group, despite significant differences in baseline characteristics among MDR-TB and non-MDR-TB patients, no independent predictor variables could be identified.CONCLUSION: In Hong Kong, non-permanent residents, frequent travel and young age were independent
predictors of MDR-TB among previously treated patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Confidence Intervals</subject><subject>Emigration and Immigration</subject><subject>Female</subject><subject>Hong Kong</subject><subject>Hong Kong - epidemiology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Multidrug-Resistant</subject><subject>Mycobacterium</subject><subject>Odds Ratio</subject><subject>Pneumology</subject><subject>Prevalence</subject><subject>Prevention and actions</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Tuberculosis</subject><subject>Tuberculosis - drug therapy</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Multidrug-Resistant - epidemiology</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFEEMxxtR3HX1K0hf9NaQVNerL4KsjxUXRNFzkanHUGNP9VoPQT-93c7oTcwhCeGXf-Cfe90lahSDmhjcX3tgahgVThfdo1IOAAwR1cPuArXCUYC87F58iuVrH8jWJZc-LLk_trlGl9t-yL7EUinVvradz7bNyzroY-pvlrTv36_pcfcg0Fz8k3O96r68ef35-ma4_fD23fXL2yFyEHVwVgop3Mi49Yq8t6NWVgnuMEhCIC2sVMwyp5UDHxj3jriFsNNyp4PD8ap7ftK9y8u35ks1x1isn2dKfmnFyIlzxYT4L4iT5BKAr-DTM9h2R-_MXY5Hyj_MH2tW4NkZoGJpDpmSjeUvx0ACm_h28eOJi2nvUyVzWFpOqxkmWhMb1dmZ7RHbH8x3ZGladxmCZsIg55NxPtDquamUzf6nKbhpvvqX5kkwHrbMALSB34Hs3MBkKNdtIsZfSGee4A</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>LAW, W. 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C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i405t-dc6565d324ce7aeec387c754d1f6a10a85c672c2d87d0ef24eda4c0fb86b8fd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antitubercular Agents - therapeutic use</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Confidence Intervals</topic><topic>Emigration and Immigration</topic><topic>Female</topic><topic>Hong Kong</topic><topic>Hong Kong - epidemiology</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Multidrug-Resistant</topic><topic>Mycobacterium</topic><topic>Odds Ratio</topic><topic>Pneumology</topic><topic>Prevalence</topic><topic>Prevention and actions</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Tuberculosis</topic><topic>Tuberculosis - drug therapy</topic><topic>Tuberculosis - epidemiology</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Tuberculosis, Multidrug-Resistant - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LAW, W. S</creatorcontrib><creatorcontrib>YEW, W. W</creatorcontrib><creatorcontrib>CHIU LEUNG, C</creatorcontrib><creatorcontrib>KAM, K. M</creatorcontrib><creatorcontrib>TAM, C. M</creatorcontrib><creatorcontrib>CHAN, C. K</creatorcontrib><creatorcontrib>LEUNG, C. C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of tuberculosis and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LAW, W. S</au><au>YEW, W. W</au><au>CHIU LEUNG, C</au><au>KAM, K. M</au><au>TAM, C. M</au><au>CHAN, C. K</au><au>LEUNG, C. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for multidrug-resistant tuberculosis in Hong Kong</atitle><jtitle>The international journal of tuberculosis and lung disease</jtitle><addtitle>Int J Tuberc Lung Dis</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>12</volume><issue>9</issue><spage>1065</spage><epage>1070</epage><pages>1065-1070</pages><issn>1027-3719</issn><eissn>1815-7920</eissn><abstract>SETTING: Previous anti-tuberculosis treatment is a widely reported risk factor for multidrug-resistant tuberculosis (MDR-TB), whereas other risk factors are less well described. In Hong Kong, the clinical characteristics of MDR-TB have not been systematically evaluated.OBJECTIVE:
To explore the risk factors for MDR-TB in Hong Kong.DESIGN: MDR-TB patients treated between 1999 and 2003 were compared with non-MDR-TB patients by stratification of previous anti-tuberculosis treatment.RESULTS: One hundred and fifty-six MDR-TB patients, including 93 with and 63 without
a previous history of anti-tuberculosis treatment, were identified. Among the 322 non-MDR-TB controls, respectively 192 and 130 patients did and did not have a previous history of anti-tuberculosis treatment. Using logistic regression analysis, non-permanent residents (OR 6.85, 95%CI 1.38-34.09),
frequent travel (OR 2.48, 95%CI 1.07-5.74) and younger age were found to be independent predictors of MDR-TB in previously treated patients, whereas living on financial assistance just failed to reach statistical significance (OR 2.75, 95%CI 0.98-7.68, P = 0.05).
In the treatment-naïve group, despite significant differences in baseline characteristics among MDR-TB and non-MDR-TB patients, no independent predictor variables could be identified.CONCLUSION: In Hong Kong, non-permanent residents, frequent travel and young age were independent
predictors of MDR-TB among previously treated patients.</abstract><cop>Paris, France</cop><pub>IUATLD</pub><pmid>18713506</pmid><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Antitubercular Agents - therapeutic use Bacterial diseases Biological and medical sciences Case-Control Studies Confidence Intervals Emigration and Immigration Female Hong Kong Hong Kong - epidemiology Human bacterial diseases Humans Infectious diseases Logistic Models Male Medical sciences Middle Aged Miscellaneous Multidrug-Resistant Mycobacterium Odds Ratio Pneumology Prevalence Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Registries Risk Factors Tuberculosis Tuberculosis - drug therapy Tuberculosis - epidemiology Tuberculosis and atypical mycobacterial infections Tuberculosis, Multidrug-Resistant - epidemiology |
| title | Risk factors for multidrug-resistant tuberculosis in Hong Kong |
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