Aortic pulse wave velocity in young normotensives with a family history of hypertension

OBJECTIVETo assess the effect of selected clinical and biochemical parameters, with particular consideration of familial hypertension, on the pulse wave velocity (PWV) in young normotensives. SUBJECTS AND METHODSSeventy voluntary students were enrolled (mean age 22.3 ± 2.1 years), 39 men and 31 wome...

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Veröffentlicht in:Journal of hypertension 1999-12, Vol.17 (12 Suppl), p.1821-1824
Hauptverfasser: Rajzer, Marek W, Klocek, Marek, Kawecka-Jaszcz, Kalina, Czarnecka, Danuta, Baran, Wiktoria, Dudek, Konrad, Petriczek, Tomasz
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container_end_page 1824
container_issue 12 Suppl
container_start_page 1821
container_title Journal of hypertension
container_volume 17
creator Rajzer, Marek W
Klocek, Marek
Kawecka-Jaszcz, Kalina
Czarnecka, Danuta
Baran, Wiktoria
Dudek, Konrad
Petriczek, Tomasz
description OBJECTIVETo assess the effect of selected clinical and biochemical parameters, with particular consideration of familial hypertension, on the pulse wave velocity (PWV) in young normotensives. SUBJECTS AND METHODSSeventy voluntary students were enrolled (mean age 22.3 ± 2.1 years), 39 men and 31 women, with normal blood pressure. A history was obtained with respect to diabetes mellitus, ischaemic heart disease, lipid disorders and arterial hypertension in the family. The subjects were subdivided into two groupsthose with (n = 33) and without (n = 37) a family history of arterial hypertension, and blood pressure and heart rate were measured three times and total cholesterol and its subfractions determined in plasma. The carotid to femoral PWV was measured using an automatic computerized recorder and analysed by the Complior® program. RESULTSThe subjects with a family history of arterial hypertension had higher blood pressure levels (systolic and diastolic blood pressure, pulse pressure and mean arterial pressure), as well as mean body mass index and low-density lipoprotein (LDL) cholesterol. The PWV in this group did not differ from that in the subjects without a family history of arterial hypertension (9.69 ± 2.8 versus 9.32 ± 2.0). However, the PWV was significantly higher in males than females (10.62 ± 2.2 versus 7.86 ± 1.13, P < 0.0001) and there was a significant positive correlation between male gender and PWV. CONCLUSIONSFamilial arterial hypertension does not significantly affect aortic stiffness in terms of PWV. Male gender in this population of young healthy subjects is one of the most important factors associated with central arterial stiffness.
doi_str_mv 10.1097/00004872-199917121-00006
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SUBJECTS AND METHODSSeventy voluntary students were enrolled (mean age 22.3 ± 2.1 years), 39 men and 31 women, with normal blood pressure. A history was obtained with respect to diabetes mellitus, ischaemic heart disease, lipid disorders and arterial hypertension in the family. The subjects were subdivided into two groupsthose with (n = 33) and without (n = 37) a family history of arterial hypertension, and blood pressure and heart rate were measured three times and total cholesterol and its subfractions determined in plasma. The carotid to femoral PWV was measured using an automatic computerized recorder and analysed by the Complior® program. RESULTSThe subjects with a family history of arterial hypertension had higher blood pressure levels (systolic and diastolic blood pressure, pulse pressure and mean arterial pressure), as well as mean body mass index and low-density lipoprotein (LDL) cholesterol. The PWV in this group did not differ from that in the subjects without a family history of arterial hypertension (9.69 ± 2.8 versus 9.32 ± 2.0). However, the PWV was significantly higher in males than females (10.62 ± 2.2 versus 7.86 ± 1.13, P &lt; 0.0001) and there was a significant positive correlation between male gender and PWV. CONCLUSIONSFamilial arterial hypertension does not significantly affect aortic stiffness in terms of PWV. Male gender in this population of young healthy subjects is one of the most important factors associated with central arterial stiffness.</description><identifier>ISSN: 0263-6352</identifier><identifier>EISSN: 1473-5598</identifier><identifier>DOI: 10.1097/00004872-199917121-00006</identifier><identifier>PMID: 10703874</identifier><identifier>CODEN: JOHYD3</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams &amp; Wilkins, Inc</publisher><subject>Adult ; Aorta - physiology ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Body Mass Index ; Cardiology. Vascular system ; Cholesterol, LDL - blood ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Female ; Humans ; Hypertension - genetics ; Male ; Medical Records ; Medical sciences ; Pulse ; Reference Values ; Sex Characteristics ; Time Factors</subject><ispartof>Journal of hypertension, 1999-12, Vol.17 (12 Suppl), p.1821-1824</ispartof><rights>1999 Lippincott Williams &amp; Wilkins, Inc.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3856-915b5672b106f155914370cc6694ab0d14a7fc09ce6fd4cea726f7634efb39373</citedby><cites>FETCH-LOGICAL-c3856-915b5672b106f155914370cc6694ab0d14a7fc09ce6fd4cea726f7634efb39373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=1322233$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10703874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rajzer, Marek W</creatorcontrib><creatorcontrib>Klocek, Marek</creatorcontrib><creatorcontrib>Kawecka-Jaszcz, Kalina</creatorcontrib><creatorcontrib>Czarnecka, Danuta</creatorcontrib><creatorcontrib>Baran, Wiktoria</creatorcontrib><creatorcontrib>Dudek, Konrad</creatorcontrib><creatorcontrib>Petriczek, Tomasz</creatorcontrib><title>Aortic pulse wave velocity in young normotensives with a family history of hypertension</title><title>Journal of hypertension</title><addtitle>J Hypertens</addtitle><description>OBJECTIVETo assess the effect of selected clinical and biochemical parameters, with particular consideration of familial hypertension, on the pulse wave velocity (PWV) in young normotensives. SUBJECTS AND METHODSSeventy voluntary students were enrolled (mean age 22.3 ± 2.1 years), 39 men and 31 women, with normal blood pressure. A history was obtained with respect to diabetes mellitus, ischaemic heart disease, lipid disorders and arterial hypertension in the family. The subjects were subdivided into two groupsthose with (n = 33) and without (n = 37) a family history of arterial hypertension, and blood pressure and heart rate were measured three times and total cholesterol and its subfractions determined in plasma. The carotid to femoral PWV was measured using an automatic computerized recorder and analysed by the Complior® program. RESULTSThe subjects with a family history of arterial hypertension had higher blood pressure levels (systolic and diastolic blood pressure, pulse pressure and mean arterial pressure), as well as mean body mass index and low-density lipoprotein (LDL) cholesterol. The PWV in this group did not differ from that in the subjects without a family history of arterial hypertension (9.69 ± 2.8 versus 9.32 ± 2.0). However, the PWV was significantly higher in males than females (10.62 ± 2.2 versus 7.86 ± 1.13, P &lt; 0.0001) and there was a significant positive correlation between male gender and PWV. CONCLUSIONSFamilial arterial hypertension does not significantly affect aortic stiffness in terms of PWV. Male gender in this population of young healthy subjects is one of the most important factors associated with central arterial stiffness.</description><subject>Adult</subject><subject>Aorta - physiology</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Cardiology. Vascular system</subject><subject>Cholesterol, LDL - blood</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - genetics</subject><subject>Male</subject><subject>Medical Records</subject><subject>Medical sciences</subject><subject>Pulse</subject><subject>Reference Values</subject><subject>Sex Characteristics</subject><subject>Time Factors</subject><issn>0263-6352</issn><issn>1473-5598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9P3DAQxa2qqGxpv0LlA-otrf_Fjo8IlYKExAXE0XK848bFiRc72VW-fbPsFnrpXEZ6-s2b0RuEMCXfKNHqO1lKNIpVVGtNFWW02kvyHVpRoXhV17p5j1aESV5JXrNT9LGU3wvRaMU_oFNKFOGNEiv0eJHyGBzeTLEA3tkt4C3E5MI44zDgOU3DLzyk3KcRhhK2UPAujB222Ns-xBl3oYwpzzh53M0byC9YGj6hE28Xy8_HfoYern7cX15Xt3c_by4vbivHm1pWmtZtLRVrKZGeLmdTwRVxTkotbEvWVFjlHdEOpF8LB1Yx6ZXkAnzLNVf8DH09-G5yep6gjKYPxUGMdoA0FbP4iJrTPdgcQJdTKRm82eTQ2zwbSsw-VPM3VPMa6oskl9Evxx1T28P6n8FDigtwfgRscTb6bAcXyhvHGWOcL5g4YLsUR8jlKU47yKYDG8fO_O-n_A8lho8j</recordid><startdate>199912</startdate><enddate>199912</enddate><creator>Rajzer, Marek W</creator><creator>Klocek, Marek</creator><creator>Kawecka-Jaszcz, Kalina</creator><creator>Czarnecka, Danuta</creator><creator>Baran, Wiktoria</creator><creator>Dudek, Konrad</creator><creator>Petriczek, Tomasz</creator><general>Lippincott Williams &amp; Wilkins, Inc</general><general>Lippincott Williams &amp; Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199912</creationdate><title>Aortic pulse wave velocity in young normotensives with a family history of hypertension</title><author>Rajzer, Marek W ; Klocek, Marek ; Kawecka-Jaszcz, Kalina ; Czarnecka, Danuta ; Baran, Wiktoria ; Dudek, Konrad ; Petriczek, Tomasz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3856-915b5672b106f155914370cc6694ab0d14a7fc09ce6fd4cea726f7634efb39373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aorta - physiology</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>Cardiology. Vascular system</topic><topic>Cholesterol, LDL - blood</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - genetics</topic><topic>Male</topic><topic>Medical Records</topic><topic>Medical sciences</topic><topic>Pulse</topic><topic>Reference Values</topic><topic>Sex Characteristics</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rajzer, Marek W</creatorcontrib><creatorcontrib>Klocek, Marek</creatorcontrib><creatorcontrib>Kawecka-Jaszcz, Kalina</creatorcontrib><creatorcontrib>Czarnecka, Danuta</creatorcontrib><creatorcontrib>Baran, Wiktoria</creatorcontrib><creatorcontrib>Dudek, Konrad</creatorcontrib><creatorcontrib>Petriczek, Tomasz</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rajzer, Marek W</au><au>Klocek, Marek</au><au>Kawecka-Jaszcz, Kalina</au><au>Czarnecka, Danuta</au><au>Baran, Wiktoria</au><au>Dudek, Konrad</au><au>Petriczek, Tomasz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aortic pulse wave velocity in young normotensives with a family history of hypertension</atitle><jtitle>Journal of hypertension</jtitle><addtitle>J Hypertens</addtitle><date>1999-12</date><risdate>1999</risdate><volume>17</volume><issue>12 Suppl</issue><spage>1821</spage><epage>1824</epage><pages>1821-1824</pages><issn>0263-6352</issn><eissn>1473-5598</eissn><coden>JOHYD3</coden><abstract>OBJECTIVETo assess the effect of selected clinical and biochemical parameters, with particular consideration of familial hypertension, on the pulse wave velocity (PWV) in young normotensives. SUBJECTS AND METHODSSeventy voluntary students were enrolled (mean age 22.3 ± 2.1 years), 39 men and 31 women, with normal blood pressure. A history was obtained with respect to diabetes mellitus, ischaemic heart disease, lipid disorders and arterial hypertension in the family. The subjects were subdivided into two groupsthose with (n = 33) and without (n = 37) a family history of arterial hypertension, and blood pressure and heart rate were measured three times and total cholesterol and its subfractions determined in plasma. The carotid to femoral PWV was measured using an automatic computerized recorder and analysed by the Complior® program. RESULTSThe subjects with a family history of arterial hypertension had higher blood pressure levels (systolic and diastolic blood pressure, pulse pressure and mean arterial pressure), as well as mean body mass index and low-density lipoprotein (LDL) cholesterol. The PWV in this group did not differ from that in the subjects without a family history of arterial hypertension (9.69 ± 2.8 versus 9.32 ± 2.0). However, the PWV was significantly higher in males than females (10.62 ± 2.2 versus 7.86 ± 1.13, P &lt; 0.0001) and there was a significant positive correlation between male gender and PWV. CONCLUSIONSFamilial arterial hypertension does not significantly affect aortic stiffness in terms of PWV. Male gender in this population of young healthy subjects is one of the most important factors associated with central arterial stiffness.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams &amp; Wilkins, Inc</pub><pmid>10703874</pmid><doi>10.1097/00004872-199917121-00006</doi><tpages>4</tpages></addata></record>
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subjects Adult
Aorta - physiology
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Body Mass Index
Cardiology. Vascular system
Cholesterol, LDL - blood
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Female
Humans
Hypertension - genetics
Male
Medical Records
Medical sciences
Pulse
Reference Values
Sex Characteristics
Time Factors
title Aortic pulse wave velocity in young normotensives with a family history of hypertension
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