MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination
Characterization of regulatory mechanisms affecting microRNA (miRNA) expression and activity is providing novel clues for the identification of genes and complex regulatory circuits that determine cell and tissue specificity. Here, we review the molecular events leading to miRNA biogenesis and activ...
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| Veröffentlicht in: | Cardiovascular research 2008-09, Vol.79 (4), p.553-561 |
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| container_title | Cardiovascular research |
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| creator | Fazi, Francesco Nervi, Clara |
| description | Characterization of regulatory mechanisms affecting microRNA (miRNA) expression and activity is providing novel clues for the identification of genes and complex regulatory circuits that determine cell and tissue specificity. Here, we review the molecular events leading to miRNA biogenesis and activity, focusing above all on endogenous and epigenetic transcriptional networks involving miRNA in early development, cellular lineage specification/differentiation of nervous, skeletal and cardiac muscle tissues and in haematopoiesis, as the de-regulation of such networks may be relevant to disease pathogenesis. |
| doi_str_mv | 10.1093/cvr/cvn151 |
| format | Article |
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| ispartof | Cardiovascular research, 2008-09, Vol.79 (4), p.553-561 |
| issn | 0008-6363 1755-3245 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Cell differentiation Cell Differentiation - genetics Cell Lineage - genetics Epigenesis, Genetic Epigenetic gene regulation Gene Expression Regulation, Developmental Gene Regulatory Networks Hematopoiesis - genetics Humans MicroRNAs MicroRNAs - metabolism Muscle Development - genetics Muscle, Skeletal - metabolism Myocardium - metabolism Nerve Tissue - metabolism Transcription factors Transcription, Genetic |
| title | MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination |
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