Effect of intermittent liver ischemia on outcome in patients with hepatocellular carcinoma on liver cirrhosis
The influence on postoperative liver function of intermittent normothermic hepatic ischemia in cirrhotic patients was studied retrospectively. The mean total ischemia time was 88 (range 30-140) minutes in the hemi-hepatic occlusion group, and 68 (range 10-187) minutes in the total occlusion group. T...
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| Veröffentlicht in: | The journal of medical investigation 1999-08, Vol.46 (3-4), p.205-212 |
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| container_title | The journal of medical investigation |
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| creator | Harada, M Yogita, S Tashiro, S Narioka, J Horiuchi, M Ohnishi, T Miyake, H Ishikawa, M Fukuda, Y Wada, D |
| description | The influence on postoperative liver function of intermittent normothermic hepatic ischemia in cirrhotic patients was studied retrospectively. The mean total ischemia time was 88 (range 30-140) minutes in the hemi-hepatic occlusion group, and 68 (range 10-187) minutes in the total occlusion group. There were no operative deaths due to hepatic failure. Postoperative liver function improved within 1 week of the operation. There was no significant difference in the incidence of postoperative complications between the groups. Thus normothermic hepatic ischemia is tolerated for up to 180 minutes in the cirrhotic liver when an intermittent technique (15 minutes clamped and 5 minutes unclamped) is used. |
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The mean total ischemia time was 88 (range 30-140) minutes in the hemi-hepatic occlusion group, and 68 (range 10-187) minutes in the total occlusion group. There were no operative deaths due to hepatic failure. Postoperative liver function improved within 1 week of the operation. There was no significant difference in the incidence of postoperative complications between the groups. Thus normothermic hepatic ischemia is tolerated for up to 180 minutes in the cirrhotic liver when an intermittent technique (15 minutes clamped and 5 minutes unclamped) is used.</description><identifier>ISSN: 1343-1420</identifier><identifier>PMID: 10687317</identifier><language>eng</language><publisher>Japan</publisher><subject>Carcinoma, Hepatocellular - physiopathology ; Carcinoma, Hepatocellular - surgery ; Humans ; Intraoperative Period ; Ischemia ; Liver - blood supply ; Liver - physiopathology ; Liver - surgery ; Liver Cirrhosis - physiopathology ; Liver Cirrhosis - surgery ; Liver Neoplasms - physiopathology ; Liver Neoplasms - surgery ; Middle Aged ; Postoperative Complications ; Retrospective Studies ; Time Factors ; Treatment Outcome</subject><ispartof>The journal of medical investigation, 1999-08, Vol.46 (3-4), p.205-212</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10687317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harada, M</creatorcontrib><creatorcontrib>Yogita, S</creatorcontrib><creatorcontrib>Tashiro, S</creatorcontrib><creatorcontrib>Narioka, J</creatorcontrib><creatorcontrib>Horiuchi, M</creatorcontrib><creatorcontrib>Ohnishi, T</creatorcontrib><creatorcontrib>Miyake, H</creatorcontrib><creatorcontrib>Ishikawa, M</creatorcontrib><creatorcontrib>Fukuda, Y</creatorcontrib><creatorcontrib>Wada, D</creatorcontrib><title>Effect of intermittent liver ischemia on outcome in patients with hepatocellular carcinoma on liver cirrhosis</title><title>The journal of medical investigation</title><addtitle>J Med Invest</addtitle><description>The influence on postoperative liver function of intermittent normothermic hepatic ischemia in cirrhotic patients was studied retrospectively. The mean total ischemia time was 88 (range 30-140) minutes in the hemi-hepatic occlusion group, and 68 (range 10-187) minutes in the total occlusion group. There were no operative deaths due to hepatic failure. Postoperative liver function improved within 1 week of the operation. There was no significant difference in the incidence of postoperative complications between the groups. Thus normothermic hepatic ischemia is tolerated for up to 180 minutes in the cirrhotic liver when an intermittent technique (15 minutes clamped and 5 minutes unclamped) is used.</description><subject>Carcinoma, Hepatocellular - physiopathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Humans</subject><subject>Intraoperative Period</subject><subject>Ischemia</subject><subject>Liver - blood supply</subject><subject>Liver - physiopathology</subject><subject>Liver - surgery</subject><subject>Liver Cirrhosis - physiopathology</subject><subject>Liver Cirrhosis - surgery</subject><subject>Liver Neoplasms - physiopathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Middle Aged</subject><subject>Postoperative Complications</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1343-1420</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LAzEQhnNQbK3-BcnJ20Ky-exRSv2Aghc9L9nshI1skppkFf-9i62nl4FnHmbeC7SmjLOG8pas0HUpH4QwJoS4QitKpFaMqjUKe-fAVpwc9rFCDr5WiBVP_gsy9sWOELzBKeI0V5sCLBg-muoXqOBvX0c8wjInC9M0TyZja7L1MYW_pZPG-pzHVHy5QZfOTAVuz7lB74_7t91zc3h9etk9HJpIBa3N0A9Gs9aAFIOmkjoirXbCES16KjhTtm8NZYIy1nIwFpSCfis4B0IHLR3boPuT95jT5wyldmF5ZbnQREhz6eSWc66VWMC7Mzj3AYbumH0w-af7L4j9AujLYzM</recordid><startdate>199908</startdate><enddate>199908</enddate><creator>Harada, M</creator><creator>Yogita, S</creator><creator>Tashiro, S</creator><creator>Narioka, J</creator><creator>Horiuchi, M</creator><creator>Ohnishi, T</creator><creator>Miyake, H</creator><creator>Ishikawa, M</creator><creator>Fukuda, Y</creator><creator>Wada, D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199908</creationdate><title>Effect of intermittent liver ischemia on outcome in patients with hepatocellular carcinoma on liver cirrhosis</title><author>Harada, M ; Yogita, S ; Tashiro, S ; Narioka, J ; Horiuchi, M ; Ohnishi, T ; Miyake, H ; Ishikawa, M ; Fukuda, Y ; Wada, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-n151t-dbda832ae65d8161f06c8f5f085b15437cb2a13513324eace77eb9544e01d86f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Carcinoma, Hepatocellular - physiopathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Humans</topic><topic>Intraoperative Period</topic><topic>Ischemia</topic><topic>Liver - blood supply</topic><topic>Liver - physiopathology</topic><topic>Liver - surgery</topic><topic>Liver Cirrhosis - physiopathology</topic><topic>Liver Cirrhosis - surgery</topic><topic>Liver Neoplasms - physiopathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Middle Aged</topic><topic>Postoperative Complications</topic><topic>Retrospective Studies</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harada, M</creatorcontrib><creatorcontrib>Yogita, S</creatorcontrib><creatorcontrib>Tashiro, S</creatorcontrib><creatorcontrib>Narioka, J</creatorcontrib><creatorcontrib>Horiuchi, M</creatorcontrib><creatorcontrib>Ohnishi, T</creatorcontrib><creatorcontrib>Miyake, H</creatorcontrib><creatorcontrib>Ishikawa, M</creatorcontrib><creatorcontrib>Fukuda, Y</creatorcontrib><creatorcontrib>Wada, D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of medical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harada, M</au><au>Yogita, S</au><au>Tashiro, S</au><au>Narioka, J</au><au>Horiuchi, M</au><au>Ohnishi, T</au><au>Miyake, H</au><au>Ishikawa, M</au><au>Fukuda, Y</au><au>Wada, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of intermittent liver ischemia on outcome in patients with hepatocellular carcinoma on liver cirrhosis</atitle><jtitle>The journal of medical investigation</jtitle><addtitle>J Med Invest</addtitle><date>1999-08</date><risdate>1999</risdate><volume>46</volume><issue>3-4</issue><spage>205</spage><epage>212</epage><pages>205-212</pages><issn>1343-1420</issn><abstract>The influence on postoperative liver function of intermittent normothermic hepatic ischemia in cirrhotic patients was studied retrospectively. 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| ispartof | The journal of medical investigation, 1999-08, Vol.46 (3-4), p.205-212 |
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| language | eng |
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| source | MEDLINE; Open Access Titles of Japan; EZB-FREE-00999 freely available EZB journals |
| subjects | Carcinoma, Hepatocellular - physiopathology Carcinoma, Hepatocellular - surgery Humans Intraoperative Period Ischemia Liver - blood supply Liver - physiopathology Liver - surgery Liver Cirrhosis - physiopathology Liver Cirrhosis - surgery Liver Neoplasms - physiopathology Liver Neoplasms - surgery Middle Aged Postoperative Complications Retrospective Studies Time Factors Treatment Outcome |
| title | Effect of intermittent liver ischemia on outcome in patients with hepatocellular carcinoma on liver cirrhosis |
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