ANTIMICROBIAL ACTIVITIES OF MEROPENEM AGAINST CLINICALLY ISOLATED STRAINS IN 1997
In order to evaluate antimicrobial activity of meropenem (MEPM), minimum inhibitory concentrations (MICs) of MEPM and control drugs were determined against clinical isolates in 1997. The results were as follows; 1. Antimicrobial activities of MEPM against Gram-positive bacteria were stronger than th...
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| Veröffentlicht in: | Japanese journal of antibiotics 1999/12/25, Vol.52(12), pp.695-720 |
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| container_title | Japanese journal of antibiotics |
| container_volume | 52 |
| creator | SUZUKI, YUMIKO MATSUMOTO, YOSHIHIRO NISHINARI, CHISATO ENDO, HARUMI ISHIHARA, RIKA DEGUCHI, KOICHI |
| description | In order to evaluate antimicrobial activity of meropenem (MEPM), minimum inhibitory concentrations (MICs) of MEPM and control drugs were determined against clinical isolates in 1997. The results were as follows; 1. Antimicrobial activities of MEPM against Gram-positive bacteria were stronger than those of cephems (CEPs) and were approximately equal to those of imipenem (IPM) and panipenem (PAPM). 2. Carbapenems showed strong antimicrobial activities against Enterobacteriaceae, Glucose non-fermentative Gram-negative rods and Bacteroides fragilis group that were multiple drug resistant including the third generation CEPs. Antimicrobial activities of MEPM against these organisms were stronger than those of IPM and PAPM. By comparing antimicrobial activities of MEPM against Gram-negative bacteria in 1997 with thoseobtained in 1993, increase of resistance was not observed. 3. MIC-ranges of MEPM were low against the resistant strains of Pseudomonas aeruginosa to IPM and PAPM. It was considered that these resistant strains were not expressing oprD products (D2 porin protein), forming main outer membrane porin channels of carbapenems and basic amino acids. |
| doi_str_mv | 10.11553/antibiotics1968b.52.695 |
| format | Article |
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The results were as follows; 1. Antimicrobial activities of MEPM against Gram-positive bacteria were stronger than those of cephems (CEPs) and were approximately equal to those of imipenem (IPM) and panipenem (PAPM). 2. Carbapenems showed strong antimicrobial activities against Enterobacteriaceae, Glucose non-fermentative Gram-negative rods and Bacteroides fragilis group that were multiple drug resistant including the third generation CEPs. Antimicrobial activities of MEPM against these organisms were stronger than those of IPM and PAPM. By comparing antimicrobial activities of MEPM against Gram-negative bacteria in 1997 with thoseobtained in 1993, increase of resistance was not observed. 3. MIC-ranges of MEPM were low against the resistant strains of Pseudomonas aeruginosa to IPM and PAPM. It was considered that these resistant strains were not expressing oprD products (D2 porin protein), forming main outer membrane porin channels of carbapenems and basic amino acids.</description><identifier>ISSN: 0368-2781</identifier><identifier>EISSN: 2186-5477</identifier><identifier>DOI: 10.11553/antibiotics1968b.52.695</identifier><identifier>PMID: 10695025</identifier><language>jpn</language><publisher>Japan: Japan Antibiotics Research Association</publisher><subject>Bacteria - drug effects ; Bacteria - isolation & purification ; Carbapenems - pharmacology ; Cephalosporins - pharmacology ; Drug Resistance, Microbial ; Humans ; Imipenem - pharmacology ; Thienamycins - pharmacology ; Time Factors</subject><ispartof>The Japanese Journal of Antibiotics, 1999/12/25, Vol.52(12), pp.695-720</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10695025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SUZUKI, YUMIKO</creatorcontrib><creatorcontrib>MATSUMOTO, YOSHIHIRO</creatorcontrib><creatorcontrib>NISHINARI, CHISATO</creatorcontrib><creatorcontrib>ENDO, HARUMI</creatorcontrib><creatorcontrib>ISHIHARA, RIKA</creatorcontrib><creatorcontrib>DEGUCHI, KOICHI</creatorcontrib><title>ANTIMICROBIAL ACTIVITIES OF MEROPENEM AGAINST CLINICALLY ISOLATED STRAINS IN 1997</title><title>Japanese journal of antibiotics</title><addtitle>Jpn. J. Antibiotics</addtitle><description>In order to evaluate antimicrobial activity of meropenem (MEPM), minimum inhibitory concentrations (MICs) of MEPM and control drugs were determined against clinical isolates in 1997. The results were as follows; 1. Antimicrobial activities of MEPM against Gram-positive bacteria were stronger than those of cephems (CEPs) and were approximately equal to those of imipenem (IPM) and panipenem (PAPM). 2. Carbapenems showed strong antimicrobial activities against Enterobacteriaceae, Glucose non-fermentative Gram-negative rods and Bacteroides fragilis group that were multiple drug resistant including the third generation CEPs. Antimicrobial activities of MEPM against these organisms were stronger than those of IPM and PAPM. By comparing antimicrobial activities of MEPM against Gram-negative bacteria in 1997 with thoseobtained in 1993, increase of resistance was not observed. 3. MIC-ranges of MEPM were low against the resistant strains of Pseudomonas aeruginosa to IPM and PAPM. It was considered that these resistant strains were not expressing oprD products (D2 porin protein), forming main outer membrane porin channels of carbapenems and basic amino acids.</description><subject>Bacteria - drug effects</subject><subject>Bacteria - isolation & purification</subject><subject>Carbapenems - pharmacology</subject><subject>Cephalosporins - pharmacology</subject><subject>Drug Resistance, Microbial</subject><subject>Humans</subject><subject>Imipenem - pharmacology</subject><subject>Thienamycins - pharmacology</subject><subject>Time Factors</subject><issn>0368-2781</issn><issn>2186-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0E1TgzAQBuCMo2M7tX_ByckbNZuQQI6ItGakoAWd8cQECEqnXwI9-O-l09qDl93DPvseXoQwkAkA5-xeb7o6r7ddXbQghZtPOJ0IyS_QkIIrLG47ziUaEiZcizouDNC4beucMHBc2idcowGQ3hPKh-jVi1I1V_4iflBeiD0_Ve8qVUGC4ymeB4v4JYiCOfZmnoqSFPuhipTvheEHVkkcemnwiJN0cThiFWGQ0rlBV5VetWZ82iP0Ng1S_8kK49nh1VqCJJ1VuboUwhZFVTIKpNSi0A7nILXIc-nSXMqiYk5p-gFCcwEMKilKXTCdywrYCN0dc3fN9ntv2i5b121hViu9Mdt9mwlp2zYhtIe3J7jP16bMdk291s1P9ldCD56PYNl2-tOcgW76ilcm-993xmkG9DD7gLMqvnSTmQ37BVQzdvQ</recordid><startdate>199912</startdate><enddate>199912</enddate><creator>SUZUKI, YUMIKO</creator><creator>MATSUMOTO, YOSHIHIRO</creator><creator>NISHINARI, CHISATO</creator><creator>ENDO, HARUMI</creator><creator>ISHIHARA, RIKA</creator><creator>DEGUCHI, KOICHI</creator><general>Japan Antibiotics Research Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199912</creationdate><title>ANTIMICROBIAL ACTIVITIES OF MEROPENEM AGAINST CLINICALLY ISOLATED STRAINS IN 1997</title><author>SUZUKI, YUMIKO ; MATSUMOTO, YOSHIHIRO ; NISHINARI, CHISATO ; ENDO, HARUMI ; ISHIHARA, RIKA ; DEGUCHI, KOICHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j190t-f8ad6646cfd3210da6ca75519a6bb982b99cf37def3716a56131f96dac3ab9f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1999</creationdate><topic>Bacteria - drug effects</topic><topic>Bacteria - isolation & purification</topic><topic>Carbapenems - pharmacology</topic><topic>Cephalosporins - pharmacology</topic><topic>Drug Resistance, Microbial</topic><topic>Humans</topic><topic>Imipenem - pharmacology</topic><topic>Thienamycins - pharmacology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SUZUKI, YUMIKO</creatorcontrib><creatorcontrib>MATSUMOTO, YOSHIHIRO</creatorcontrib><creatorcontrib>NISHINARI, CHISATO</creatorcontrib><creatorcontrib>ENDO, HARUMI</creatorcontrib><creatorcontrib>ISHIHARA, RIKA</creatorcontrib><creatorcontrib>DEGUCHI, KOICHI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SUZUKI, YUMIKO</au><au>MATSUMOTO, YOSHIHIRO</au><au>NISHINARI, CHISATO</au><au>ENDO, HARUMI</au><au>ISHIHARA, RIKA</au><au>DEGUCHI, KOICHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ANTIMICROBIAL ACTIVITIES OF MEROPENEM AGAINST CLINICALLY ISOLATED STRAINS IN 1997</atitle><jtitle>Japanese journal of antibiotics</jtitle><addtitle>Jpn. J. Antibiotics</addtitle><date>1999-12</date><risdate>1999</risdate><volume>52</volume><issue>12</issue><spage>695</spage><epage>720</epage><pages>695-720</pages><issn>0368-2781</issn><eissn>2186-5477</eissn><abstract>In order to evaluate antimicrobial activity of meropenem (MEPM), minimum inhibitory concentrations (MICs) of MEPM and control drugs were determined against clinical isolates in 1997. The results were as follows; 1. Antimicrobial activities of MEPM against Gram-positive bacteria were stronger than those of cephems (CEPs) and were approximately equal to those of imipenem (IPM) and panipenem (PAPM). 2. Carbapenems showed strong antimicrobial activities against Enterobacteriaceae, Glucose non-fermentative Gram-negative rods and Bacteroides fragilis group that were multiple drug resistant including the third generation CEPs. Antimicrobial activities of MEPM against these organisms were stronger than those of IPM and PAPM. By comparing antimicrobial activities of MEPM against Gram-negative bacteria in 1997 with thoseobtained in 1993, increase of resistance was not observed. 3. MIC-ranges of MEPM were low against the resistant strains of Pseudomonas aeruginosa to IPM and PAPM. It was considered that these resistant strains were not expressing oprD products (D2 porin protein), forming main outer membrane porin channels of carbapenems and basic amino acids.</abstract><cop>Japan</cop><pub>Japan Antibiotics Research Association</pub><pmid>10695025</pmid><doi>10.11553/antibiotics1968b.52.695</doi><tpages>26</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0368-2781 |
| ispartof | The Japanese Journal of Antibiotics, 1999/12/25, Vol.52(12), pp.695-720 |
| issn | 0368-2781 2186-5477 |
| language | jpn |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Bacteria - drug effects Bacteria - isolation & purification Carbapenems - pharmacology Cephalosporins - pharmacology Drug Resistance, Microbial Humans Imipenem - pharmacology Thienamycins - pharmacology Time Factors |
| title | ANTIMICROBIAL ACTIVITIES OF MEROPENEM AGAINST CLINICALLY ISOLATED STRAINS IN 1997 |
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