Inhibition of plasminogen activator inhibitor release in endothelial cell cultures by antisense oligodeoxyribonucleotides with a 5'-end lipophilic modification

A series of conjugates containing residues of lipophilic alcohols covalently bound to 5' end of oligodeoxyribonucleotides targeted against human plasminogen activator inhibitor (PAI-1) mRNA was synthesized via the oxathiaphospholane approach. The highest anti-PAI-1 activity in EA.hy 926 endothe...

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Veröffentlicht in:	Acta biochimica polonica 1999-01, Vol.46 (3), p.679-691
Hauptverfasser:	Kobylańska, A, Pluskota, E, Swiatkowska, M, Wójcik, M, Cierniewska-Cieślak, A, Krakowiak, A, Boczkowska, M, Pawłowska, Z, Okruszek, A, Koziołkiewicz, M, Cierniewski, C S, Stec, W J
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Cell Line DNA Primers - genetics Endothelium, Vascular - drug effects Endothelium, Vascular - secretion Humans Oligodeoxyribonucleotides, Antisense - chemical synthesis Oligodeoxyribonucleotides, Antisense - genetics Oligodeoxyribonucleotides, Antisense - pharmacology Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - secretion RNA, Messenger - genetics RNA, Messenger - metabolism
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