Metformin improves endothelial function in normoinsulinemic PCOS patients: a new prospective
BACKGROUND Metformin was reported to improve the alterations of endothelial reactivity in normal-weight subjects with polycystic ovary syndrome (PCOS). The aim of the present study was to investigate the mechanisms of action of this drug on the vascular function of this population. METHODS Thirteen...
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| Veröffentlicht in: | Human reproduction (Oxford) 2008-09, Vol.23 (9), p.2127-2133 |
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| creator | Romualdi, D. Costantini, B. Selvaggi, L. Giuliani, M. Cristello, F. Macrì, F. Bompiani, A. Lanzone, A. Guido, M. |
| description | BACKGROUND Metformin was reported to improve the alterations of endothelial reactivity in normal-weight subjects with polycystic ovary syndrome (PCOS). The aim of the present study was to investigate the mechanisms of action of this drug on the vascular function of this population. METHODS Thirteen normal-weight, normoinsulinemic and normolipemic PCOS women were studied before and after 6 months of metformin treatment (1000 mg/day). The endothelial function was assessed by evaluating the flow-mediated dilatation (FMD) of the brachial artery. We correlated this parameter with the endocrine-metabolic features of the patients. RESULTS Metformin significantly reduced testosterone (1.56 ± 0.52 after 6 months versus 2.98 ± 1.00 at baseline) and 17-hydroxyprogesterone (0.03 ± 0.01 versus 0.06 ± 0.02 nmol/ml) levels, without affecting gluco-insulinemic parameters. Concomitantly, the basal vessel diameter and the FMD significantly increased (4.12 ± 0.68 versus 3.2 ± 0.41 and 5.2 ± 0.6 versus 3.76 ± 0.5 mm, respectively), thus documenting an improved endothelial function. CONCLUSIONS Our data confirm the positive effects of metformin on the altered vascular reactivity, a precocious marker of cardiovascular risk, in normoinsulinemic PCOS subjects. This improvement seems to be mediated through hormonal changes, thus highlighting the detrimental role of hyperandrogenemia on the endothelial function, even beyond the metabolic factors. However, a direct effect of metformin on the endothelium should not be excluded. |
| doi_str_mv | 10.1093/humrep/den230 |
| format | Article |
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The aim of the present study was to investigate the mechanisms of action of this drug on the vascular function of this population. METHODS Thirteen normal-weight, normoinsulinemic and normolipemic PCOS women were studied before and after 6 months of metformin treatment (1000 mg/day). The endothelial function was assessed by evaluating the flow-mediated dilatation (FMD) of the brachial artery. We correlated this parameter with the endocrine-metabolic features of the patients. RESULTS Metformin significantly reduced testosterone (1.56 ± 0.52 after 6 months versus 2.98 ± 1.00 at baseline) and 17-hydroxyprogesterone (0.03 ± 0.01 versus 0.06 ± 0.02 nmol/ml) levels, without affecting gluco-insulinemic parameters. Concomitantly, the basal vessel diameter and the FMD significantly increased (4.12 ± 0.68 versus 3.2 ± 0.41 and 5.2 ± 0.6 versus 3.76 ± 0.5 mm, respectively), thus documenting an improved endothelial function. CONCLUSIONS Our data confirm the positive effects of metformin on the altered vascular reactivity, a precocious marker of cardiovascular risk, in normoinsulinemic PCOS subjects. This improvement seems to be mediated through hormonal changes, thus highlighting the detrimental role of hyperandrogenemia on the endothelial function, even beyond the metabolic factors. However, a direct effect of metformin on the endothelium should not be excluded.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/den230</identifier><identifier>PMID: 18567896</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Androgens ; Androgens - physiology ; Biological and medical sciences ; Body mass index ; Body Weight ; Brachial Artery - drug effects ; Brachial Artery - physiopathology ; Cardiovascular disease ; Cardiovascular diseases ; Diabetes ; endothelial function ; Endothelium ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiopathology ; Female ; Glucose ; Gynecology ; Gynecology. Andrology. Obstetrics ; High density lipoprotein ; Humans ; Hypertension ; Insulin - physiology ; Insulin resistance ; Medical sciences ; Menstruation ; Metabolism ; Metformin ; Metformin - therapeutic use ; Obesity ; Obstetrics ; Ovaries ; Patients ; Plasma ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - drug therapy ; Testosterone ; Vasodilation - drug effects</subject><ispartof>Human reproduction (Oxford), 2008-09, Vol.23 (9), p.2127-2133</ispartof><rights>The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2008</rights><rights>2008 INIST-CNRS</rights><rights>The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-66d214262135a3df1a9b60970cacd8bdd919d868b2bbe8e2b24684f091bb50933</citedby><cites>FETCH-LOGICAL-c458t-66d214262135a3df1a9b60970cacd8bdd919d868b2bbe8e2b24684f091bb50933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20621011$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18567896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romualdi, D.</creatorcontrib><creatorcontrib>Costantini, B.</creatorcontrib><creatorcontrib>Selvaggi, L.</creatorcontrib><creatorcontrib>Giuliani, M.</creatorcontrib><creatorcontrib>Cristello, F.</creatorcontrib><creatorcontrib>Macrì, F.</creatorcontrib><creatorcontrib>Bompiani, A.</creatorcontrib><creatorcontrib>Lanzone, A.</creatorcontrib><creatorcontrib>Guido, M.</creatorcontrib><title>Metformin improves endothelial function in normoinsulinemic PCOS patients: a new prospective</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>BACKGROUND Metformin was reported to improve the alterations of endothelial reactivity in normal-weight subjects with polycystic ovary syndrome (PCOS). The aim of the present study was to investigate the mechanisms of action of this drug on the vascular function of this population. METHODS Thirteen normal-weight, normoinsulinemic and normolipemic PCOS women were studied before and after 6 months of metformin treatment (1000 mg/day). The endothelial function was assessed by evaluating the flow-mediated dilatation (FMD) of the brachial artery. We correlated this parameter with the endocrine-metabolic features of the patients. RESULTS Metformin significantly reduced testosterone (1.56 ± 0.52 after 6 months versus 2.98 ± 1.00 at baseline) and 17-hydroxyprogesterone (0.03 ± 0.01 versus 0.06 ± 0.02 nmol/ml) levels, without affecting gluco-insulinemic parameters. Concomitantly, the basal vessel diameter and the FMD significantly increased (4.12 ± 0.68 versus 3.2 ± 0.41 and 5.2 ± 0.6 versus 3.76 ± 0.5 mm, respectively), thus documenting an improved endothelial function. CONCLUSIONS Our data confirm the positive effects of metformin on the altered vascular reactivity, a precocious marker of cardiovascular risk, in normoinsulinemic PCOS subjects. This improvement seems to be mediated through hormonal changes, thus highlighting the detrimental role of hyperandrogenemia on the endothelial function, even beyond the metabolic factors. However, a direct effect of metformin on the endothelium should not be excluded.</description><subject>Adult</subject><subject>Androgens</subject><subject>Androgens - physiology</subject><subject>Biological and medical sciences</subject><subject>Body mass index</subject><subject>Body Weight</subject><subject>Brachial Artery - drug effects</subject><subject>Brachial Artery - physiopathology</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Diabetes</subject><subject>endothelial function</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>Glucose</subject><subject>Gynecology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Insulin - physiology</subject><subject>Insulin resistance</subject><subject>Medical sciences</subject><subject>Menstruation</subject><subject>Metabolism</subject><subject>Metformin</subject><subject>Metformin - therapeutic use</subject><subject>Obesity</subject><subject>Obstetrics</subject><subject>Ovaries</subject><subject>Patients</subject><subject>Plasma</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - drug therapy</subject><subject>Testosterone</subject><subject>Vasodilation - drug effects</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MuL1TAUB-AginMdXbqVIChu6uSkbW7qTurjCiOjOKKIEPI4ZTK2aU3aUf97Iy0juHGVQL6cx4-Q-8CeAmvKk4tliDidOAy8ZDfIDirBCl7W7CbZMS5kASDgiNxJ6ZKxfJXiNjkCWYu9bMSOfH2LczfGwQfqhymOV5goBjfOF9h73dNuCXb2Y34NNGQ3-pCW3gccvKXv2rMPdNKzxzCnZ1TTgD9oLpImzJ-u8C651ek-4b3tPCYfX708bw_F6dnrN-3z08JWtZwLIRyHigsOZa1L14FujGDNnlltnTTONdA4KaThxqBEbnglZNWxBoypcwblMXm81s29vy-YZjX4ZLHvdcBxSUo0VcW5EBk-_AdejksMeTbFAaSEqmYZFSuyeZMUsVNT9IOOvxQw9SdztWau1syzf7AVXcyA7q_eQs7g0QZ0srrvog7Wp2vHWd6cAWT3ZHXjMv235zajTzP-vMY6flNiX-5rdfj8RbWf3r-Aw7lUbfkb9EmpcA</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Romualdi, D.</creator><creator>Costantini, B.</creator><creator>Selvaggi, L.</creator><creator>Giuliani, M.</creator><creator>Cristello, F.</creator><creator>Macrì, F.</creator><creator>Bompiani, A.</creator><creator>Lanzone, A.</creator><creator>Guido, M.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080901</creationdate><title>Metformin improves endothelial function in normoinsulinemic PCOS patients: a new prospective</title><author>Romualdi, D. ; Costantini, B. ; Selvaggi, L. ; Giuliani, M. ; Cristello, F. ; Macrì, F. ; Bompiani, A. ; Lanzone, A. ; Guido, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-66d214262135a3df1a9b60970cacd8bdd919d868b2bbe8e2b24684f091bb50933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Androgens</topic><topic>Androgens - physiology</topic><topic>Biological and medical sciences</topic><topic>Body mass index</topic><topic>Body Weight</topic><topic>Brachial Artery - drug effects</topic><topic>Brachial Artery - physiopathology</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Diabetes</topic><topic>endothelial function</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>Glucose</topic><topic>Gynecology</topic><topic>Gynecology. 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Obstetrics</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Insulin - physiology</topic><topic>Insulin resistance</topic><topic>Medical sciences</topic><topic>Menstruation</topic><topic>Metabolism</topic><topic>Metformin</topic><topic>Metformin - therapeutic use</topic><topic>Obesity</topic><topic>Obstetrics</topic><topic>Ovaries</topic><topic>Patients</topic><topic>Plasma</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - drug therapy</topic><topic>Testosterone</topic><topic>Vasodilation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romualdi, D.</creatorcontrib><creatorcontrib>Costantini, B.</creatorcontrib><creatorcontrib>Selvaggi, L.</creatorcontrib><creatorcontrib>Giuliani, M.</creatorcontrib><creatorcontrib>Cristello, F.</creatorcontrib><creatorcontrib>Macrì, F.</creatorcontrib><creatorcontrib>Bompiani, A.</creatorcontrib><creatorcontrib>Lanzone, A.</creatorcontrib><creatorcontrib>Guido, M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romualdi, D.</au><au>Costantini, B.</au><au>Selvaggi, L.</au><au>Giuliani, M.</au><au>Cristello, F.</au><au>Macrì, F.</au><au>Bompiani, A.</au><au>Lanzone, A.</au><au>Guido, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metformin improves endothelial function in normoinsulinemic PCOS patients: a new prospective</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>23</volume><issue>9</issue><spage>2127</spage><epage>2133</epage><pages>2127-2133</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>BACKGROUND Metformin was reported to improve the alterations of endothelial reactivity in normal-weight subjects with polycystic ovary syndrome (PCOS). The aim of the present study was to investigate the mechanisms of action of this drug on the vascular function of this population. METHODS Thirteen normal-weight, normoinsulinemic and normolipemic PCOS women were studied before and after 6 months of metformin treatment (1000 mg/day). The endothelial function was assessed by evaluating the flow-mediated dilatation (FMD) of the brachial artery. We correlated this parameter with the endocrine-metabolic features of the patients. RESULTS Metformin significantly reduced testosterone (1.56 ± 0.52 after 6 months versus 2.98 ± 1.00 at baseline) and 17-hydroxyprogesterone (0.03 ± 0.01 versus 0.06 ± 0.02 nmol/ml) levels, without affecting gluco-insulinemic parameters. Concomitantly, the basal vessel diameter and the FMD significantly increased (4.12 ± 0.68 versus 3.2 ± 0.41 and 5.2 ± 0.6 versus 3.76 ± 0.5 mm, respectively), thus documenting an improved endothelial function. CONCLUSIONS Our data confirm the positive effects of metformin on the altered vascular reactivity, a precocious marker of cardiovascular risk, in normoinsulinemic PCOS subjects. This improvement seems to be mediated through hormonal changes, thus highlighting the detrimental role of hyperandrogenemia on the endothelial function, even beyond the metabolic factors. However, a direct effect of metformin on the endothelium should not be excluded.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>18567896</pmid><doi>10.1093/humrep/den230</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Androgens Androgens - physiology Biological and medical sciences Body mass index Body Weight Brachial Artery - drug effects Brachial Artery - physiopathology Cardiovascular disease Cardiovascular diseases Diabetes endothelial function Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Female Glucose Gynecology Gynecology. Andrology. Obstetrics High density lipoprotein Humans Hypertension Insulin - physiology Insulin resistance Medical sciences Menstruation Metabolism Metformin Metformin - therapeutic use Obesity Obstetrics Ovaries Patients Plasma Polycystic ovary syndrome Polycystic Ovary Syndrome - drug therapy Testosterone Vasodilation - drug effects |
| title | Metformin improves endothelial function in normoinsulinemic PCOS patients: a new prospective |
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