Combined therapy in treatment of murine infection by Fusarium solani
Objectives We evaluated the efficacy of voriconazole, amphotericin B and micafungin alone and combined in a murine model of disseminated infection by Fusarium solani. Methods Immunosuppressed mice were treated with voriconazole at 60 mg/kg/day, amphotericin B at 3 mg/kg/day, micafungin at 10 mg/kg/d...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2008-09, Vol.62 (3), p.543-546 |
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| creator | Ruíz-Cendoya, Mery Mariné, Marçal Guarro, Josep |
| description | Objectives We evaluated the efficacy of voriconazole, amphotericin B and micafungin alone and combined in a murine model of disseminated infection by Fusarium solani. Methods Immunosuppressed mice were treated with voriconazole at 60 mg/kg/day, amphotericin B at 3 mg/kg/day, micafungin at 10 mg/kg/day or combinations of these antifungal drugs. For survival studies, treatment began 1 day after infection and continued for 10 days. For tissue burden studies, animals were sacrificed on day 6 of the treatment and the fungal load in the kidneys and spleens was measured. The experiments were carried out using two different clinical strains of F. solani. Results Only the combination of voriconazole plus amphotericin B prolonged the survival of the mice versus the controls for the two strains tested. However, this combination only reduced tissue burden in the kidney and spleen of mice infected by one strain. The other treatments were clearly less effective. Conclusions Voriconazole plus amphotericin B may have a role in the treatment of fusariosis. |
| doi_str_mv | 10.1093/jac/dkn215 |
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Methods Immunosuppressed mice were treated with voriconazole at 60 mg/kg/day, amphotericin B at 3 mg/kg/day, micafungin at 10 mg/kg/day or combinations of these antifungal drugs. For survival studies, treatment began 1 day after infection and continued for 10 days. For tissue burden studies, animals were sacrificed on day 6 of the treatment and the fungal load in the kidneys and spleens was measured. The experiments were carried out using two different clinical strains of F. solani. Results Only the combination of voriconazole plus amphotericin B prolonged the survival of the mice versus the controls for the two strains tested. However, this combination only reduced tissue burden in the kidney and spleen of mice infected by one strain. The other treatments were clearly less effective. Conclusions Voriconazole plus amphotericin B may have a role in the treatment of fusariosis.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkn215</identifier><identifier>PMID: 18495651</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject><![CDATA[amphotericin B ; Amphotericin B - administration & dosage ; Amphotericin B - therapeutic use ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal Agents - administration & dosage ; Antifungal Agents - therapeutic use ; Biological and medical sciences ; Colony Count, Microbial ; Comparative studies ; Drug Therapy, Combination ; Echinocandins - administration & dosage ; Echinocandins - therapeutic use ; Fungi ; Fusarium - drug effects ; Fusarium solani ; Immunocompromised Host ; Infections ; Kidney - microbiology ; Lipopeptides ; Lipoproteins - administration & dosage ; Lipoproteins - therapeutic use ; Male ; Medical sciences ; micafungin ; Mice ; murine model ; Mycoses - drug therapy ; Mycoses - microbiology ; Pharmacology ; Pharmacology. Drug treatments ; Pyrimidines - administration & dosage ; Pyrimidines - therapeutic use ; Rodents ; Spleen - microbiology ; Survival Analysis ; Triazoles - administration & dosage ; Triazoles - therapeutic use ; Voriconazole]]></subject><ispartof>Journal of antimicrobial chemotherapy, 2008-09, Vol.62 (3), p.543-546</ispartof><rights>The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org 2008</rights><rights>2008 INIST-CNRS</rights><rights>The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-23b5bc6c2194fbad2f9b9f372c563f3a397030c42fd6130fa4476ff0b5136aee3</citedby><cites>FETCH-LOGICAL-c477t-23b5bc6c2194fbad2f9b9f372c563f3a397030c42fd6130fa4476ff0b5136aee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1583,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20635292$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18495651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruíz-Cendoya, Mery</creatorcontrib><creatorcontrib>Mariné, Marçal</creatorcontrib><creatorcontrib>Guarro, Josep</creatorcontrib><title>Combined therapy in treatment of murine infection by Fusarium solani</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Objectives We evaluated the efficacy of voriconazole, amphotericin B and micafungin alone and combined in a murine model of disseminated infection by Fusarium solani. Methods Immunosuppressed mice were treated with voriconazole at 60 mg/kg/day, amphotericin B at 3 mg/kg/day, micafungin at 10 mg/kg/day or combinations of these antifungal drugs. For survival studies, treatment began 1 day after infection and continued for 10 days. For tissue burden studies, animals were sacrificed on day 6 of the treatment and the fungal load in the kidneys and spleens was measured. The experiments were carried out using two different clinical strains of F. solani. Results Only the combination of voriconazole plus amphotericin B prolonged the survival of the mice versus the controls for the two strains tested. However, this combination only reduced tissue burden in the kidney and spleen of mice infected by one strain. The other treatments were clearly less effective. Conclusions Voriconazole plus amphotericin B may have a role in the treatment of fusariosis.</description><subject>amphotericin B</subject><subject>Amphotericin B - administration & dosage</subject><subject>Amphotericin B - therapeutic use</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal Agents - administration & dosage</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Colony Count, Microbial</subject><subject>Comparative studies</subject><subject>Drug Therapy, Combination</subject><subject>Echinocandins - administration & dosage</subject><subject>Echinocandins - therapeutic use</subject><subject>Fungi</subject><subject>Fusarium - drug effects</subject><subject>Fusarium solani</subject><subject>Immunocompromised Host</subject><subject>Infections</subject><subject>Kidney - microbiology</subject><subject>Lipopeptides</subject><subject>Lipoproteins - administration & dosage</subject><subject>Lipoproteins - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>micafungin</subject><subject>Mice</subject><subject>murine model</subject><subject>Mycoses - drug therapy</subject><subject>Mycoses - microbiology</subject><subject>Pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrimidines - administration & dosage</subject><subject>Pyrimidines - therapeutic use</subject><subject>Rodents</subject><subject>Spleen - microbiology</subject><subject>Survival Analysis</subject><subject>Triazoles - administration & dosage</subject><subject>Triazoles - therapeutic use</subject><subject>Voriconazole</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctKAzEUBuAgiq3VjQ8gg6ALYWzuaZZSryDoooK4CZlMgqmdSU1mwL69kRYFF7oKnHycc5IfgEMEzxGUZDzXZly_tRixLTBElMMSQ4m2wRASyEpBGRmAvZTmEELO-GQXDNCESsYZGoLLaWgq39q66F5t1MtV4duii1Z3jW27Irii6WO-z2VnTedDW1Sr4rpPOvq-KVJY6Nbvgx2nF8kebM4ReLq-mk1vy_uHm7vpxX1pqBBdiUnFKsMNRpK6StfYyUo6IrBhnDiiiRR5Y0Oxqzki0GlKBXcOVgwRrq0lI3C67ruM4b23qVONT8Yu8g429ElxSYlEWPwLkRScUUQyPP4F56GPbX6EwkhwziaCZ3S2RiaGlKJ1ahl9o-NKIai-ElA5AbVOIOOjTce-amz9QzdfnsHJBuhk9MJF3Rqfvh2GnDAs8Y8L_fLvgeXa-dTZj2-p45viggimbp9f1OPjDMNngdSUfAIKRalx</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Ruíz-Cendoya, Mery</creator><creator>Mariné, Marçal</creator><creator>Guarro, Josep</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080901</creationdate><title>Combined therapy in treatment of murine infection by Fusarium solani</title><author>Ruíz-Cendoya, Mery ; Mariné, Marçal ; Guarro, Josep</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-23b5bc6c2194fbad2f9b9f372c563f3a397030c42fd6130fa4476ff0b5136aee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>amphotericin B</topic><topic>Amphotericin B - administration & dosage</topic><topic>Amphotericin B - therapeutic use</topic><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal Agents - administration & dosage</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Colony Count, Microbial</topic><topic>Comparative studies</topic><topic>Drug Therapy, Combination</topic><topic>Echinocandins - administration & dosage</topic><topic>Echinocandins - therapeutic use</topic><topic>Fungi</topic><topic>Fusarium - drug effects</topic><topic>Fusarium solani</topic><topic>Immunocompromised Host</topic><topic>Infections</topic><topic>Kidney - microbiology</topic><topic>Lipopeptides</topic><topic>Lipoproteins - administration & dosage</topic><topic>Lipoproteins - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>micafungin</topic><topic>Mice</topic><topic>murine model</topic><topic>Mycoses - drug therapy</topic><topic>Mycoses - microbiology</topic><topic>Pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrimidines - administration & dosage</topic><topic>Pyrimidines - therapeutic use</topic><topic>Rodents</topic><topic>Spleen - microbiology</topic><topic>Survival Analysis</topic><topic>Triazoles - administration & dosage</topic><topic>Triazoles - therapeutic use</topic><topic>Voriconazole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruíz-Cendoya, Mery</creatorcontrib><creatorcontrib>Mariné, Marçal</creatorcontrib><creatorcontrib>Guarro, Josep</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruíz-Cendoya, Mery</au><au>Mariné, Marçal</au><au>Guarro, Josep</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined therapy in treatment of murine infection by Fusarium solani</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>62</volume><issue>3</issue><spage>543</spage><epage>546</epage><pages>543-546</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>Objectives We evaluated the efficacy of voriconazole, amphotericin B and micafungin alone and combined in a murine model of disseminated infection by Fusarium solani. Methods Immunosuppressed mice were treated with voriconazole at 60 mg/kg/day, amphotericin B at 3 mg/kg/day, micafungin at 10 mg/kg/day or combinations of these antifungal drugs. For survival studies, treatment began 1 day after infection and continued for 10 days. For tissue burden studies, animals were sacrificed on day 6 of the treatment and the fungal load in the kidneys and spleens was measured. The experiments were carried out using two different clinical strains of F. solani. Results Only the combination of voriconazole plus amphotericin B prolonged the survival of the mice versus the controls for the two strains tested. However, this combination only reduced tissue burden in the kidney and spleen of mice infected by one strain. The other treatments were clearly less effective. Conclusions Voriconazole plus amphotericin B may have a role in the treatment of fusariosis.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>18495651</pmid><doi>10.1093/jac/dkn215</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of antimicrobial chemotherapy, 2008-09, Vol.62 (3), p.543-546 |
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| subjects | amphotericin B Amphotericin B - administration & dosage Amphotericin B - therapeutic use Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Agents - administration & dosage Antifungal Agents - therapeutic use Biological and medical sciences Colony Count, Microbial Comparative studies Drug Therapy, Combination Echinocandins - administration & dosage Echinocandins - therapeutic use Fungi Fusarium - drug effects Fusarium solani Immunocompromised Host Infections Kidney - microbiology Lipopeptides Lipoproteins - administration & dosage Lipoproteins - therapeutic use Male Medical sciences micafungin Mice murine model Mycoses - drug therapy Mycoses - microbiology Pharmacology Pharmacology. Drug treatments Pyrimidines - administration & dosage Pyrimidines - therapeutic use Rodents Spleen - microbiology Survival Analysis Triazoles - administration & dosage Triazoles - therapeutic use Voriconazole |
| title | Combined therapy in treatment of murine infection by Fusarium solani |
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