Cardioprotective efficacy of verapamil and mibefradil in young UM-X7.1 cardiomyopathic hamsters

Since calcium overload and increased in T-type calcium channel activity have been observed in the cardiomyopathic (CM) hamster, we hypothesized that mibefradil (Ro 40-5967), a new T- and L-type calcium channel blocker, may exert significant cardioprotection in the early phase of the disease. Young (...

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Veröffentlicht in:	Cardiovascular drugs and therapy 1999-11, Vol.13 (6), p.525-530
Hauptverfasser:	PAQUETTE, F, JASMIN, G, DUMONT, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomarkers Calcinosis - pathology Calcium Channel Blockers - therapeutic use Cardiomyopathies - drug therapy Cardiomyopathies - pathology Cardiovascular Agents - therapeutic use Cardiovascular system Cricetinae Female Heart - drug effects Male Medical sciences Mibefradil - therapeutic use Miscellaneous Muscle, Skeletal - drug effects Muscle, Skeletal - pathology Myocardium - pathology Necrosis Pharmacology. Drug treatments Time Factors Tongue - drug effects Tongue - pathology Verapamil - therapeutic use
Online-Zugang:	Volltext
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