Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D-knockout (PDE4D−/−) mice

Elevation of intracellular cyclic adenosine monophosphate (cAMP) concentrations and subsequent regulation of downstream target gene expression through phosphorylation of cAMP‐responsive element binding protein (CREB) is hypothesized to underlie the mechanism(s) of long‐term memory (LTM) formation. T...

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Veröffentlicht in:	The European journal of neuroscience 2008-08, Vol.28 (3), p.625-632
Hauptverfasser:	Rutten, Kris, Misner, Dinah L., Works, Melissa, Blokland, Arjan, Novak, Thomas J., Santarelli, Luca, Wallace, Tanya L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - physiology cAMP Conditioning, Classical - physiology Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism Electrophysiology Fear - physiology fear conditioning gene knockout Isoenzymes - genetics Isoenzymes - metabolism Learning - physiology Long-Term Potentiation - physiology LTP Memory - physiology Mice Mice, Inbred C57BL Mice, Knockout Motor Activity - physiology mouse Neuronal Plasticity - physiology PDE4 Synaptic Transmission - physiology
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