Distinctive homing profile of pathogen-specific activated lymphocytes in human urinary tract infection
Abstract In contrast to other mucosal sites, information on migration/homing of lymphocytes activated in the human urinary tract is lacking. The expression of lymphocyte homing receptors (HR) on pathogen-specific antibody-secreting cells (ASC) originating from the urinary tract (patients with pyelon...
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| Veröffentlicht in: | Clinical immunology (Orlando, Fla.) Fla.), 2008-09, Vol.128 (3), p.427-434 |
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| creator | Kantele, Anu M Palkola, Nina V Arvilommi, Heikki S Kantele, Jussi M |
| description | Abstract In contrast to other mucosal sites, information on migration/homing of lymphocytes activated in the human urinary tract is lacking. The expression of lymphocyte homing receptors (HR) on pathogen-specific antibody-secreting cells (ASC) originating from the urinary tract (patients with pyelonephritis, PN) was compared to that on antigen-specific ASC originating from the intestine (patients with gastroenteritis) or from a parenteral site (tetanus toxoid-immunized volunteers). In the PN group, 61% of ASC expressed the gut HR, α4 β7, 52% the peripheral lymph node HR, L-selectin, and 13% the skin HR, CLA. This homing profile of urinary tract-originating lymphocytes was found to differ from both of the two major vaccination routes, intestinal (less gut-targeting) or parenteral (more gut-targeting, less targeting to parenteral sites). This information on targeting of the immune response may prove useful when developing vaccines against urinary tract infection (UTI). |
| doi_str_mv | 10.1016/j.clim.2008.05.003 |
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The expression of lymphocyte homing receptors (HR) on pathogen-specific antibody-secreting cells (ASC) originating from the urinary tract (patients with pyelonephritis, PN) was compared to that on antigen-specific ASC originating from the intestine (patients with gastroenteritis) or from a parenteral site (tetanus toxoid-immunized volunteers). In the PN group, 61% of ASC expressed the gut HR, α4 β7, 52% the peripheral lymph node HR, L-selectin, and 13% the skin HR, CLA. This homing profile of urinary tract-originating lymphocytes was found to differ from both of the two major vaccination routes, intestinal (less gut-targeting) or parenteral (more gut-targeting, less targeting to parenteral sites). This information on targeting of the immune response may prove useful when developing vaccines against urinary tract infection (UTI).</description><identifier>ISSN: 1521-6616</identifier><identifier>ISSN: 0090-1229</identifier><identifier>EISSN: 1521-7035</identifier><identifier>DOI: 10.1016/j.clim.2008.05.003</identifier><identifier>PMID: 18585960</identifier><identifier>CODEN: CLIIFY</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adhesion molecules ; Adolescent ; Adult ; Aged ; Allergy and Immunology ; Antibody-Producing Cells - immunology ; Antibody-Producing Cells - metabolism ; B cells ; Bacterial diseases ; Bacterial diseases of the urinary system ; Biological and medical sciences ; Cell Movement ; Cell trafficking ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gastroenteritis - immunology ; Gastrointestinal Tract - immunology ; Gastrointestinal Tract - metabolism ; Human bacterial diseases ; Humans ; Infectious diseases ; Integrins - immunology ; Integrins - metabolism ; L-Selectin - immunology ; L-Selectin - metabolism ; Lymphocyte Activation ; Male ; Medical sciences ; Middle Aged ; Mucosa ; Pyelonephritis - immunology ; Receptors, Lymphocyte Homing - immunology ; Receptors, Lymphocyte Homing - metabolism ; Tetanus Toxoid - immunology ; Urinary tract ; Urinary Tract Infections - immunology ; Urinary Tract Infections - metabolism</subject><ispartof>Clinical immunology (Orlando, Fla.), 2008-09, Vol.128 (3), p.427-434</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-da5d252fb22449d432bc5410e65bfee8e86edfdf9a0236e2d356f3606d86b0d73</citedby><cites>FETCH-LOGICAL-c470t-da5d252fb22449d432bc5410e65bfee8e86edfdf9a0236e2d356f3606d86b0d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1521661608006542$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20618199$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18585960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kantele, Anu M</creatorcontrib><creatorcontrib>Palkola, Nina V</creatorcontrib><creatorcontrib>Arvilommi, Heikki S</creatorcontrib><creatorcontrib>Kantele, Jussi M</creatorcontrib><title>Distinctive homing profile of pathogen-specific activated lymphocytes in human urinary tract infection</title><title>Clinical immunology (Orlando, Fla.)</title><addtitle>Clin Immunol</addtitle><description>Abstract In contrast to other mucosal sites, information on migration/homing of lymphocytes activated in the human urinary tract is lacking. The expression of lymphocyte homing receptors (HR) on pathogen-specific antibody-secreting cells (ASC) originating from the urinary tract (patients with pyelonephritis, PN) was compared to that on antigen-specific ASC originating from the intestine (patients with gastroenteritis) or from a parenteral site (tetanus toxoid-immunized volunteers). In the PN group, 61% of ASC expressed the gut HR, α4 β7, 52% the peripheral lymph node HR, L-selectin, and 13% the skin HR, CLA. This homing profile of urinary tract-originating lymphocytes was found to differ from both of the two major vaccination routes, intestinal (less gut-targeting) or parenteral (more gut-targeting, less targeting to parenteral sites). This information on targeting of the immune response may prove useful when developing vaccines against urinary tract infection (UTI).</description><subject>Adhesion molecules</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Allergy and Immunology</subject><subject>Antibody-Producing Cells - immunology</subject><subject>Antibody-Producing Cells - metabolism</subject><subject>B cells</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the urinary system</subject><subject>Biological and medical sciences</subject><subject>Cell Movement</subject><subject>Cell trafficking</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gastroenteritis - immunology</subject><subject>Gastrointestinal Tract - immunology</subject><subject>Gastrointestinal Tract - metabolism</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Integrins - immunology</subject><subject>Integrins - metabolism</subject><subject>L-Selectin - immunology</subject><subject>L-Selectin - metabolism</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mucosa</subject><subject>Pyelonephritis - immunology</subject><subject>Receptors, Lymphocyte Homing - immunology</subject><subject>Receptors, Lymphocyte Homing - metabolism</subject><subject>Tetanus Toxoid - immunology</subject><subject>Urinary tract</subject><subject>Urinary Tract Infections - immunology</subject><subject>Urinary Tract Infections - metabolism</subject><issn>1521-6616</issn><issn>0090-1229</issn><issn>1521-7035</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk-L1TAUxYsozjj6BVxINrprvUmbtAURhvEvDLhQ1yFNbubl2SY1aQfetzflFQUXukoIv3Nz7zm3KJ5TqChQ8fpY6dFNFQPoKuAVQP2guKSc0bKFmj_c70JQcVE8SekIAJwx8bi4oB3veC_gsrDvXFqc14u7R3IIk_N3ZI7BuhFJsGRWyyHcoS_TjNpZp4naULWgIeNpmg9BnxZMxHlyWCflyRqdV_FElpjB_Gwx88E_LR5ZNSZ8tp9XxfcP77_dfCpvv3z8fHN9W-qmhaU0ihvGmR0Ya5reNDUbNG8ooOCDReywE2issb0CVgtkpubC1gKE6cQApq2vilfnunmGnyumRU4uaRxH5TGsSYq-qZuWwn9BBj0Aa7sMsjOoY0gpopVzdFMeUVKQWwzyKLcY5BaDBC5zDFn0Yq--DhOaP5Ld9wy83AGVtBptVF679JtjIGhH-z5zb84cZtPuHUaZtEOv0biYnZUmuH_38fYveUa8yz_-wBOmY1ijz3FIKhOTIL9uC7PtC3QAgjes_gXmz7yi</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Kantele, Anu M</creator><creator>Palkola, Nina V</creator><creator>Arvilommi, Heikki S</creator><creator>Kantele, Jussi M</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20080901</creationdate><title>Distinctive homing profile of pathogen-specific activated lymphocytes in human urinary tract infection</title><author>Kantele, Anu M ; Palkola, Nina V ; Arvilommi, Heikki S ; Kantele, Jussi M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-da5d252fb22449d432bc5410e65bfee8e86edfdf9a0236e2d356f3606d86b0d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adhesion molecules</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Allergy and Immunology</topic><topic>Antibody-Producing Cells - immunology</topic><topic>Antibody-Producing Cells - metabolism</topic><topic>B cells</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the urinary system</topic><topic>Biological and medical sciences</topic><topic>Cell Movement</topic><topic>Cell trafficking</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gastroenteritis - immunology</topic><topic>Gastrointestinal Tract - immunology</topic><topic>Gastrointestinal Tract - metabolism</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Integrins - immunology</topic><topic>Integrins - metabolism</topic><topic>L-Selectin - immunology</topic><topic>L-Selectin - metabolism</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mucosa</topic><topic>Pyelonephritis - immunology</topic><topic>Receptors, Lymphocyte Homing - immunology</topic><topic>Receptors, Lymphocyte Homing - metabolism</topic><topic>Tetanus Toxoid - immunology</topic><topic>Urinary tract</topic><topic>Urinary Tract Infections - immunology</topic><topic>Urinary Tract Infections - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kantele, Anu M</creatorcontrib><creatorcontrib>Palkola, Nina V</creatorcontrib><creatorcontrib>Arvilommi, Heikki S</creatorcontrib><creatorcontrib>Kantele, Jussi M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kantele, Anu M</au><au>Palkola, Nina V</au><au>Arvilommi, Heikki S</au><au>Kantele, Jussi M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinctive homing profile of pathogen-specific activated lymphocytes in human urinary tract infection</atitle><jtitle>Clinical immunology (Orlando, Fla.)</jtitle><addtitle>Clin Immunol</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>128</volume><issue>3</issue><spage>427</spage><epage>434</epage><pages>427-434</pages><issn>1521-6616</issn><issn>0090-1229</issn><eissn>1521-7035</eissn><coden>CLIIFY</coden><abstract>Abstract In contrast to other mucosal sites, information on migration/homing of lymphocytes activated in the human urinary tract is lacking. The expression of lymphocyte homing receptors (HR) on pathogen-specific antibody-secreting cells (ASC) originating from the urinary tract (patients with pyelonephritis, PN) was compared to that on antigen-specific ASC originating from the intestine (patients with gastroenteritis) or from a parenteral site (tetanus toxoid-immunized volunteers). In the PN group, 61% of ASC expressed the gut HR, α4 β7, 52% the peripheral lymph node HR, L-selectin, and 13% the skin HR, CLA. This homing profile of urinary tract-originating lymphocytes was found to differ from both of the two major vaccination routes, intestinal (less gut-targeting) or parenteral (more gut-targeting, less targeting to parenteral sites). This information on targeting of the immune response may prove useful when developing vaccines against urinary tract infection (UTI).</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>18585960</pmid><doi>10.1016/j.clim.2008.05.003</doi><tpages>8</tpages></addata></record> |
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| subjects | Adhesion molecules Adolescent Adult Aged Allergy and Immunology Antibody-Producing Cells - immunology Antibody-Producing Cells - metabolism B cells Bacterial diseases Bacterial diseases of the urinary system Biological and medical sciences Cell Movement Cell trafficking Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gastroenteritis - immunology Gastrointestinal Tract - immunology Gastrointestinal Tract - metabolism Human bacterial diseases Humans Infectious diseases Integrins - immunology Integrins - metabolism L-Selectin - immunology L-Selectin - metabolism Lymphocyte Activation Male Medical sciences Middle Aged Mucosa Pyelonephritis - immunology Receptors, Lymphocyte Homing - immunology Receptors, Lymphocyte Homing - metabolism Tetanus Toxoid - immunology Urinary tract Urinary Tract Infections - immunology Urinary Tract Infections - metabolism |
| title | Distinctive homing profile of pathogen-specific activated lymphocytes in human urinary tract infection |
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