Allylthiamindisulfide and related compounds enhance thermogenesis with increasing noradrenaline and adrenaline secretion in rats
The effects of allylthiamindisulfide, an allyl derivative of thiamin, and related compounds on thermogenesis were investigated by measuring noradrenaline and adrenaline secretion and the temperatures of interscapular brown adipose tissue (IBAT) and rectum in rats. In Experiment 1, the effects of the...
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Veröffentlicht in: | Journal of Nutritional Science and Vitaminology 1999, Vol.45(5), pp.643-653 |
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description | The effects of allylthiamindisulfide, an allyl derivative of thiamin, and related compounds on thermogenesis were investigated by measuring noradrenaline and adrenaline secretion and the temperatures of interscapular brown adipose tissue (IBAT) and rectum in rats. In Experiment 1, the effects of the administrations of allylthiamindisulfide and related compounds on noradrenaline and adrenaline secretion were evaluated as compared to thiamin in anesthetized rats. The administration of allylthiamindisulfide significantly increased the plasma concentrations of noradrenaline and adrenaline. These increases were dose dependent, while that of thiamin was not. Four synthetic compounds related to allylthiamindisulfide also increased the plasma adrenaline and noradrenaline concentrations. In Experiment 2, the effects of allylthiamindisulfide on thermogenesis were investigated by the direct measurement of temperatures in the IBAT and rectum in anesthetized rats, and compared to the effects induced by thiamin and diallyldisulfide. The temperatures in the IBAT and rectum were significantly increased by the administration of allylthiamindisulfide and diallyldisulfide, while there was no significant increase as the result of thiamin administration. These results suggest that allylthiamindisulfide and related compounds enhance thermogenesis by increasing noradrenaline and adrenaline secretion in rats |
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(Kobe Women's Univ. (Japan)) ; Shishido, C ; Wada, K ; Odaka, H ; Ikeda, H ; Iwai, K</creator><creatorcontrib>Oi, Y. (Kobe Women's Univ. (Japan)) ; Shishido, C ; Wada, K ; Odaka, H ; Ikeda, H ; Iwai, K</creatorcontrib><description>The effects of allylthiamindisulfide, an allyl derivative of thiamin, and related compounds on thermogenesis were investigated by measuring noradrenaline and adrenaline secretion and the temperatures of interscapular brown adipose tissue (IBAT) and rectum in rats. In Experiment 1, the effects of the administrations of allylthiamindisulfide and related compounds on noradrenaline and adrenaline secretion were evaluated as compared to thiamin in anesthetized rats. The administration of allylthiamindisulfide significantly increased the plasma concentrations of noradrenaline and adrenaline. These increases were dose dependent, while that of thiamin was not. Four synthetic compounds related to allylthiamindisulfide also increased the plasma adrenaline and noradrenaline concentrations. In Experiment 2, the effects of allylthiamindisulfide on thermogenesis were investigated by the direct measurement of temperatures in the IBAT and rectum in anesthetized rats, and compared to the effects induced by thiamin and diallyldisulfide. The temperatures in the IBAT and rectum were significantly increased by the administration of allylthiamindisulfide and diallyldisulfide, while there was no significant increase as the result of thiamin administration. These results suggest that allylthiamindisulfide and related compounds enhance thermogenesis by increasing noradrenaline and adrenaline secretion in rats</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.45.643</identifier><identifier>PMID: 10683815</identifier><language>eng</language><publisher>Tokyo: Center for Academic Publications Japan</publisher><subject>Adipose Tissue, Brown - physiology ; ADRENALINE ; Allyl Compounds - pharmacology ; allylthiamindisulfide (allyl derivative of thiamin) ; Animals ; Biological and medical sciences ; Body Temperature ; Body Temperature Regulation - drug effects ; EPINEFRINA ; EPINEPHRINE ; Epinephrine - metabolism ; Fundamental and applied biological sciences. Psychology ; Male ; NORADRENALINE ; NOREPINEFRINA ; NOREPINEPHRINE ; Norepinephrine - metabolism ; RAT ; RATA ; RATS ; Rats, Sprague-Dawley ; Rectum ; SECRECION ; SECRETION ; thermogenesis ; Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects ; THIAMIN ; THIAMINE ; Thiamine - analogs & derivatives ; Thiamine - pharmacology ; TIAMINA ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of Nutritional Science and Vitaminology, 1999, Vol.45(5), pp.643-653</ispartof><rights>the Center for Academic Publications Japan</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-d71a9bc6281cb704d1f1aeb6dac8208e430128520fded1126a59fc6de12fcc483</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1255288$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10683815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oi, Y. (Kobe Women's Univ. (Japan))</creatorcontrib><creatorcontrib>Shishido, C</creatorcontrib><creatorcontrib>Wada, K</creatorcontrib><creatorcontrib>Odaka, H</creatorcontrib><creatorcontrib>Ikeda, H</creatorcontrib><creatorcontrib>Iwai, K</creatorcontrib><title>Allylthiamindisulfide and related compounds enhance thermogenesis with increasing noradrenaline and adrenaline secretion in rats</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>The effects of allylthiamindisulfide, an allyl derivative of thiamin, and related compounds on thermogenesis were investigated by measuring noradrenaline and adrenaline secretion and the temperatures of interscapular brown adipose tissue (IBAT) and rectum in rats. In Experiment 1, the effects of the administrations of allylthiamindisulfide and related compounds on noradrenaline and adrenaline secretion were evaluated as compared to thiamin in anesthetized rats. The administration of allylthiamindisulfide significantly increased the plasma concentrations of noradrenaline and adrenaline. These increases were dose dependent, while that of thiamin was not. Four synthetic compounds related to allylthiamindisulfide also increased the plasma adrenaline and noradrenaline concentrations. In Experiment 2, the effects of allylthiamindisulfide on thermogenesis were investigated by the direct measurement of temperatures in the IBAT and rectum in anesthetized rats, and compared to the effects induced by thiamin and diallyldisulfide. The temperatures in the IBAT and rectum were significantly increased by the administration of allylthiamindisulfide and diallyldisulfide, while there was no significant increase as the result of thiamin administration. These results suggest that allylthiamindisulfide and related compounds enhance thermogenesis by increasing noradrenaline and adrenaline secretion in rats</description><subject>Adipose Tissue, Brown - physiology</subject><subject>ADRENALINE</subject><subject>Allyl Compounds - pharmacology</subject><subject>allylthiamindisulfide (allyl derivative of thiamin)</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Temperature</subject><subject>Body Temperature Regulation - drug effects</subject><subject>EPINEFRINA</subject><subject>EPINEPHRINE</subject><subject>Epinephrine - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>NORADRENALINE</subject><subject>NOREPINEFRINA</subject><subject>NOREPINEPHRINE</subject><subject>Norepinephrine - metabolism</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Sprague-Dawley</subject><subject>Rectum</subject><subject>SECRECION</subject><subject>SECRETION</subject><subject>thermogenesis</subject><subject>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</subject><subject>THIAMIN</subject><subject>THIAMINE</subject><subject>Thiamine - analogs & derivatives</subject><subject>Thiamine - pharmacology</subject><subject>TIAMINA</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDuP1DAURi0EYoeFihqUAtGgDH4l8ZSr5a2VoIDaumPfTDxynMF2QNvx03HIaFkXtqx7_H3yIeQ5o1vBuu7tMaRfW9lsWykekA1TitVdJ_lDsqGCsloqSi_Ik5SOlMqdkuoxuWC0VUKxZkP-XHl_6_PgYHTBujT73lmsINgqooeMtjLTeJrmYFOFYYBgsMoDxnE6YMDkUvXb5aFywUSE5MKhClMEGzGAd2FNundNWLjsplBeVBFyekoe9eATPjufl-THh_ffrz_VN18_fr6-uqlNQ2mubcdgtzctV8zsOyot6xngvrVgFKcKZfkqVw2nvUXLGG-h2fWmtch4b4xU4pK8XnNPcfo5Y8p6dMmg9xBwmpNud1IIKRbwzQqaOKUUsden6EaIt5pRvQjXi3AtG12EF_rlOXbej2jvsavhArw6A5AM-D4Wgy7953jTcLW0vluxY8pwwLs5xOyMx3-dbNeJpbdZt1J_NzYDRI2hxLxYY3qYNBxiafryjdNlCdq24i-CYK4m</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>Oi, Y. (Kobe Women's Univ. (Japan))</creator><creator>Shishido, C</creator><creator>Wada, K</creator><creator>Odaka, H</creator><creator>Ikeda, H</creator><creator>Iwai, K</creator><general>Center for Academic Publications Japan</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991001</creationdate><title>Allylthiamindisulfide and related compounds enhance thermogenesis with increasing noradrenaline and adrenaline secretion in rats</title><author>Oi, Y. (Kobe Women's Univ. (Japan)) ; Shishido, C ; Wada, K ; Odaka, H ; Ikeda, H ; Iwai, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-d71a9bc6281cb704d1f1aeb6dac8208e430128520fded1126a59fc6de12fcc483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adipose Tissue, Brown - physiology</topic><topic>ADRENALINE</topic><topic>Allyl Compounds - pharmacology</topic><topic>allylthiamindisulfide (allyl derivative of thiamin)</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Temperature</topic><topic>Body Temperature Regulation - drug effects</topic><topic>EPINEFRINA</topic><topic>EPINEPHRINE</topic><topic>Epinephrine - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>NORADRENALINE</topic><topic>NOREPINEFRINA</topic><topic>NOREPINEPHRINE</topic><topic>Norepinephrine - metabolism</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Sprague-Dawley</topic><topic>Rectum</topic><topic>SECRECION</topic><topic>SECRETION</topic><topic>thermogenesis</topic><topic>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</topic><topic>THIAMIN</topic><topic>THIAMINE</topic><topic>Thiamine - analogs & derivatives</topic><topic>Thiamine - pharmacology</topic><topic>TIAMINA</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oi, Y. (Kobe Women's Univ. (Japan))</creatorcontrib><creatorcontrib>Shishido, C</creatorcontrib><creatorcontrib>Wada, K</creatorcontrib><creatorcontrib>Odaka, H</creatorcontrib><creatorcontrib>Ikeda, H</creatorcontrib><creatorcontrib>Iwai, K</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oi, Y. (Kobe Women's Univ. (Japan))</au><au>Shishido, C</au><au>Wada, K</au><au>Odaka, H</au><au>Ikeda, H</au><au>Iwai, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allylthiamindisulfide and related compounds enhance thermogenesis with increasing noradrenaline and adrenaline secretion in rats</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>45</volume><issue>5</issue><spage>643</spage><epage>653</epage><pages>643-653</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>The effects of allylthiamindisulfide, an allyl derivative of thiamin, and related compounds on thermogenesis were investigated by measuring noradrenaline and adrenaline secretion and the temperatures of interscapular brown adipose tissue (IBAT) and rectum in rats. In Experiment 1, the effects of the administrations of allylthiamindisulfide and related compounds on noradrenaline and adrenaline secretion were evaluated as compared to thiamin in anesthetized rats. The administration of allylthiamindisulfide significantly increased the plasma concentrations of noradrenaline and adrenaline. These increases were dose dependent, while that of thiamin was not. Four synthetic compounds related to allylthiamindisulfide also increased the plasma adrenaline and noradrenaline concentrations. In Experiment 2, the effects of allylthiamindisulfide on thermogenesis were investigated by the direct measurement of temperatures in the IBAT and rectum in anesthetized rats, and compared to the effects induced by thiamin and diallyldisulfide. The temperatures in the IBAT and rectum were significantly increased by the administration of allylthiamindisulfide and diallyldisulfide, while there was no significant increase as the result of thiamin administration. These results suggest that allylthiamindisulfide and related compounds enhance thermogenesis by increasing noradrenaline and adrenaline secretion in rats</abstract><cop>Tokyo</cop><pub>Center for Academic Publications Japan</pub><pmid>10683815</pmid><doi>10.3177/jnsv.45.643</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adipose Tissue, Brown - physiology ADRENALINE Allyl Compounds - pharmacology allylthiamindisulfide (allyl derivative of thiamin) Animals Biological and medical sciences Body Temperature Body Temperature Regulation - drug effects EPINEFRINA EPINEPHRINE Epinephrine - metabolism Fundamental and applied biological sciences. Psychology Male NORADRENALINE NOREPINEFRINA NOREPINEPHRINE Norepinephrine - metabolism RAT RATA RATS Rats, Sprague-Dawley Rectum SECRECION SECRETION thermogenesis Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects THIAMIN THIAMINE Thiamine - analogs & derivatives Thiamine - pharmacology TIAMINA Vertebrates: anatomy and physiology, studies on body, several organs or systems |
title | Allylthiamindisulfide and related compounds enhance thermogenesis with increasing noradrenaline and adrenaline secretion in rats |
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