Allylthiamindisulfide and related compounds enhance thermogenesis with increasing noradrenaline and adrenaline secretion in rats

The effects of allylthiamindisulfide, an allyl derivative of thiamin, and related compounds on thermogenesis were investigated by measuring noradrenaline and adrenaline secretion and the temperatures of interscapular brown adipose tissue (IBAT) and rectum in rats. In Experiment 1, the effects of the...

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Veröffentlicht in:Journal of Nutritional Science and Vitaminology 1999, Vol.45(5), pp.643-653
Hauptverfasser: Oi, Y. (Kobe Women's Univ. (Japan)), Shishido, C, Wada, K, Odaka, H, Ikeda, H, Iwai, K
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container_issue 5
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container_title Journal of Nutritional Science and Vitaminology
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creator Oi, Y. (Kobe Women's Univ. (Japan))
Shishido, C
Wada, K
Odaka, H
Ikeda, H
Iwai, K
description The effects of allylthiamindisulfide, an allyl derivative of thiamin, and related compounds on thermogenesis were investigated by measuring noradrenaline and adrenaline secretion and the temperatures of interscapular brown adipose tissue (IBAT) and rectum in rats. In Experiment 1, the effects of the administrations of allylthiamindisulfide and related compounds on noradrenaline and adrenaline secretion were evaluated as compared to thiamin in anesthetized rats. The administration of allylthiamindisulfide significantly increased the plasma concentrations of noradrenaline and adrenaline. These increases were dose dependent, while that of thiamin was not. Four synthetic compounds related to allylthiamindisulfide also increased the plasma adrenaline and noradrenaline concentrations. In Experiment 2, the effects of allylthiamindisulfide on thermogenesis were investigated by the direct measurement of temperatures in the IBAT and rectum in anesthetized rats, and compared to the effects induced by thiamin and diallyldisulfide. The temperatures in the IBAT and rectum were significantly increased by the administration of allylthiamindisulfide and diallyldisulfide, while there was no significant increase as the result of thiamin administration. These results suggest that allylthiamindisulfide and related compounds enhance thermogenesis by increasing noradrenaline and adrenaline secretion in rats
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(Kobe Women's Univ. (Japan)) ; Shishido, C ; Wada, K ; Odaka, H ; Ikeda, H ; Iwai, K</creator><creatorcontrib>Oi, Y. (Kobe Women's Univ. (Japan)) ; Shishido, C ; Wada, K ; Odaka, H ; Ikeda, H ; Iwai, K</creatorcontrib><description>The effects of allylthiamindisulfide, an allyl derivative of thiamin, and related compounds on thermogenesis were investigated by measuring noradrenaline and adrenaline secretion and the temperatures of interscapular brown adipose tissue (IBAT) and rectum in rats. In Experiment 1, the effects of the administrations of allylthiamindisulfide and related compounds on noradrenaline and adrenaline secretion were evaluated as compared to thiamin in anesthetized rats. The administration of allylthiamindisulfide significantly increased the plasma concentrations of noradrenaline and adrenaline. These increases were dose dependent, while that of thiamin was not. Four synthetic compounds related to allylthiamindisulfide also increased the plasma adrenaline and noradrenaline concentrations. In Experiment 2, the effects of allylthiamindisulfide on thermogenesis were investigated by the direct measurement of temperatures in the IBAT and rectum in anesthetized rats, and compared to the effects induced by thiamin and diallyldisulfide. The temperatures in the IBAT and rectum were significantly increased by the administration of allylthiamindisulfide and diallyldisulfide, while there was no significant increase as the result of thiamin administration. These results suggest that allylthiamindisulfide and related compounds enhance thermogenesis by increasing noradrenaline and adrenaline secretion in rats</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.45.643</identifier><identifier>PMID: 10683815</identifier><language>eng</language><publisher>Tokyo: Center for Academic Publications Japan</publisher><subject>Adipose Tissue, Brown - physiology ; ADRENALINE ; Allyl Compounds - pharmacology ; allylthiamindisulfide (allyl derivative of thiamin) ; Animals ; Biological and medical sciences ; Body Temperature ; Body Temperature Regulation - drug effects ; EPINEFRINA ; EPINEPHRINE ; Epinephrine - metabolism ; Fundamental and applied biological sciences. Psychology ; Male ; NORADRENALINE ; NOREPINEFRINA ; NOREPINEPHRINE ; Norepinephrine - metabolism ; RAT ; RATA ; RATS ; Rats, Sprague-Dawley ; Rectum ; SECRECION ; SECRETION ; thermogenesis ; Thermoregulation. Hibernation. Estivation. 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(Kobe Women's Univ. (Japan))</creatorcontrib><creatorcontrib>Shishido, C</creatorcontrib><creatorcontrib>Wada, K</creatorcontrib><creatorcontrib>Odaka, H</creatorcontrib><creatorcontrib>Ikeda, H</creatorcontrib><creatorcontrib>Iwai, K</creatorcontrib><title>Allylthiamindisulfide and related compounds enhance thermogenesis with increasing noradrenaline and adrenaline secretion in rats</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>The effects of allylthiamindisulfide, an allyl derivative of thiamin, and related compounds on thermogenesis were investigated by measuring noradrenaline and adrenaline secretion and the temperatures of interscapular brown adipose tissue (IBAT) and rectum in rats. In Experiment 1, the effects of the administrations of allylthiamindisulfide and related compounds on noradrenaline and adrenaline secretion were evaluated as compared to thiamin in anesthetized rats. The administration of allylthiamindisulfide significantly increased the plasma concentrations of noradrenaline and adrenaline. These increases were dose dependent, while that of thiamin was not. Four synthetic compounds related to allylthiamindisulfide also increased the plasma adrenaline and noradrenaline concentrations. In Experiment 2, the effects of allylthiamindisulfide on thermogenesis were investigated by the direct measurement of temperatures in the IBAT and rectum in anesthetized rats, and compared to the effects induced by thiamin and diallyldisulfide. The temperatures in the IBAT and rectum were significantly increased by the administration of allylthiamindisulfide and diallyldisulfide, while there was no significant increase as the result of thiamin administration. These results suggest that allylthiamindisulfide and related compounds enhance thermogenesis by increasing noradrenaline and adrenaline secretion in rats</description><subject>Adipose Tissue, Brown - physiology</subject><subject>ADRENALINE</subject><subject>Allyl Compounds - pharmacology</subject><subject>allylthiamindisulfide (allyl derivative of thiamin)</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Temperature</subject><subject>Body Temperature Regulation - drug effects</subject><subject>EPINEFRINA</subject><subject>EPINEPHRINE</subject><subject>Epinephrine - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>NORADRENALINE</subject><subject>NOREPINEFRINA</subject><subject>NOREPINEPHRINE</subject><subject>Norepinephrine - metabolism</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Sprague-Dawley</subject><subject>Rectum</subject><subject>SECRECION</subject><subject>SECRETION</subject><subject>thermogenesis</subject><subject>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</subject><subject>THIAMIN</subject><subject>THIAMINE</subject><subject>Thiamine - analogs &amp; derivatives</subject><subject>Thiamine - pharmacology</subject><subject>TIAMINA</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDuP1DAURi0EYoeFihqUAtGgDH4l8ZSr5a2VoIDaumPfTDxynMF2QNvx03HIaFkXtqx7_H3yIeQ5o1vBuu7tMaRfW9lsWykekA1TitVdJ_lDsqGCsloqSi_Ik5SOlMqdkuoxuWC0VUKxZkP-XHl_6_PgYHTBujT73lmsINgqooeMtjLTeJrmYFOFYYBgsMoDxnE6YMDkUvXb5aFywUSE5MKhClMEGzGAd2FNundNWLjsplBeVBFyekoe9eATPjufl-THh_ffrz_VN18_fr6-uqlNQ2mubcdgtzctV8zsOyot6xngvrVgFKcKZfkqVw2nvUXLGG-h2fWmtch4b4xU4pK8XnNPcfo5Y8p6dMmg9xBwmpNud1IIKRbwzQqaOKUUsden6EaIt5pRvQjXi3AtG12EF_rlOXbej2jvsavhArw6A5AM-D4Wgy7953jTcLW0vluxY8pwwLs5xOyMx3-dbNeJpbdZt1J_NzYDRI2hxLxYY3qYNBxiafryjdNlCdq24i-CYK4m</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>Oi, Y. 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(Japan)) ; Shishido, C ; Wada, K ; Odaka, H ; Ikeda, H ; Iwai, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-d71a9bc6281cb704d1f1aeb6dac8208e430128520fded1126a59fc6de12fcc483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adipose Tissue, Brown - physiology</topic><topic>ADRENALINE</topic><topic>Allyl Compounds - pharmacology</topic><topic>allylthiamindisulfide (allyl derivative of thiamin)</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Temperature</topic><topic>Body Temperature Regulation - drug effects</topic><topic>EPINEFRINA</topic><topic>EPINEPHRINE</topic><topic>Epinephrine - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>NORADRENALINE</topic><topic>NOREPINEFRINA</topic><topic>NOREPINEPHRINE</topic><topic>Norepinephrine - metabolism</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Sprague-Dawley</topic><topic>Rectum</topic><topic>SECRECION</topic><topic>SECRETION</topic><topic>thermogenesis</topic><topic>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</topic><topic>THIAMIN</topic><topic>THIAMINE</topic><topic>Thiamine - analogs &amp; derivatives</topic><topic>Thiamine - pharmacology</topic><topic>TIAMINA</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oi, Y. (Kobe Women's Univ. 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In Experiment 1, the effects of the administrations of allylthiamindisulfide and related compounds on noradrenaline and adrenaline secretion were evaluated as compared to thiamin in anesthetized rats. The administration of allylthiamindisulfide significantly increased the plasma concentrations of noradrenaline and adrenaline. These increases were dose dependent, while that of thiamin was not. Four synthetic compounds related to allylthiamindisulfide also increased the plasma adrenaline and noradrenaline concentrations. In Experiment 2, the effects of allylthiamindisulfide on thermogenesis were investigated by the direct measurement of temperatures in the IBAT and rectum in anesthetized rats, and compared to the effects induced by thiamin and diallyldisulfide. The temperatures in the IBAT and rectum were significantly increased by the administration of allylthiamindisulfide and diallyldisulfide, while there was no significant increase as the result of thiamin administration. These results suggest that allylthiamindisulfide and related compounds enhance thermogenesis by increasing noradrenaline and adrenaline secretion in rats</abstract><cop>Tokyo</cop><pub>Center for Academic Publications Japan</pub><pmid>10683815</pmid><doi>10.3177/jnsv.45.643</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record>
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subjects Adipose Tissue, Brown - physiology
ADRENALINE
Allyl Compounds - pharmacology
allylthiamindisulfide (allyl derivative of thiamin)
Animals
Biological and medical sciences
Body Temperature
Body Temperature Regulation - drug effects
EPINEFRINA
EPINEPHRINE
Epinephrine - metabolism
Fundamental and applied biological sciences. Psychology
Male
NORADRENALINE
NOREPINEFRINA
NOREPINEPHRINE
Norepinephrine - metabolism
RAT
RATA
RATS
Rats, Sprague-Dawley
Rectum
SECRECION
SECRETION
thermogenesis
Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects
THIAMIN
THIAMINE
Thiamine - analogs & derivatives
Thiamine - pharmacology
TIAMINA
Vertebrates: anatomy and physiology, studies on body, several organs or systems
title Allylthiamindisulfide and related compounds enhance thermogenesis with increasing noradrenaline and adrenaline secretion in rats
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