Synthesis and silencing properties of siRNAs possessing lipophilic groups at their 3′-termini

Short-interfering RNAs (siRNAs) conjugated with lipophilic groups at their 3′-termini were synthesized. The properties of the synthesized siRNAs were examined in detail, and it was found that at low concentrations, their silencing abilities were dependent on the positions of the modifications and th...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-08, Vol.16 (16), p.7698-7704
Hauptverfasser:	Ueno, Yoshihito, Kawada, Koshi, Naito, Tomoharu, Shibata, Aya, Yoshikawa, Kayo, Kim, Hye-Sook, Wataya, Yusuke, Kitade, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Western Cholesterol Cholesterol - chemistry Cholesterol - pharmacology Endoribonucleases - metabolism HeLa Cells Humans Lipids - chemical synthesis Lipids - chemistry Lipids - pharmacology Magnetic Resonance Spectroscopy Medical sciences Miscellaneous Oleic acid Oleic Acids - chemistry Oleic Acids - pharmacology Palmitic acid Palmitic Acids - chemistry Palmitic Acids - pharmacology Pharmacology. Drug treatments RNA Interference RNA, Small Interfering - chemical synthesis RNA, Small Interfering - chemistry RNA, Small Interfering - genetics RNA, Small Interfering - pharmacology RNAi siRNA Transfection
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