Combined hepatocellular cholangiocarcinoma: prognostic factors investigated by computed tomography/magnetic resonance imaging
Summary This study was designed to assess the clinical usefulness of imaging for predicting the prognosis of patients with combined hepatocellular cholangiocarcinoma (cHCC‐CC). Between 1999 and 2004, 30 patients with histopathologically proven cHCC‐CC underwent computed tomography (CT) or magnetic r...
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| Veröffentlicht in: | International journal of clinical practice (Esher) 2008-08, Vol.62 (8), p.1199-1205 |
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| creator | Lin, G. Toh, C.-H. Wu, R.-C. Ko, S.-F. Ng, S.-H. Chou, W.-C. Tseng, J.-H. |
| description | Summary
This study was designed to assess the clinical usefulness of imaging for predicting the prognosis of patients with combined hepatocellular cholangiocarcinoma (cHCC‐CC). Between 1999 and 2004, 30 patients with histopathologically proven cHCC‐CC underwent computed tomography (CT) or magnetic resonance imaging (MRI). The imaging data and survival were analysed. Univariate log‐rank analysis of imaging findings revealed that tumour necrosis, bile duct invasion, major vascular branch invasion, multiplicity, bilobar distribution, regional lymph node involvement, regional organ invasion, distant metastasis and ascites had adverse influences on overall survival. Multivariate Cox proportional hazard analysis demonstrated that major vascular branch invasion, regional organ invasion, nodal and distant metastases were independent prognostic factors that adversely affected overall survival rates. Overall cumulative survival rates at 1, 3 and 5 years were 53%, 26% and 12%, respectively. Analysing the survival of our patients by using clinical stages of the newly updated American Joint Committee on Cancer (AJCC) classification for liver neoplasm based on the imaging findings, we found significant differences between stages I/II and III (p |
| doi_str_mv | 10.1111/j.1742-1241.2007.01291.x |
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This study was designed to assess the clinical usefulness of imaging for predicting the prognosis of patients with combined hepatocellular cholangiocarcinoma (cHCC‐CC). Between 1999 and 2004, 30 patients with histopathologically proven cHCC‐CC underwent computed tomography (CT) or magnetic resonance imaging (MRI). The imaging data and survival were analysed. Univariate log‐rank analysis of imaging findings revealed that tumour necrosis, bile duct invasion, major vascular branch invasion, multiplicity, bilobar distribution, regional lymph node involvement, regional organ invasion, distant metastasis and ascites had adverse influences on overall survival. Multivariate Cox proportional hazard analysis demonstrated that major vascular branch invasion, regional organ invasion, nodal and distant metastases were independent prognostic factors that adversely affected overall survival rates. Overall cumulative survival rates at 1, 3 and 5 years were 53%, 26% and 12%, respectively. Analysing the survival of our patients by using clinical stages of the newly updated American Joint Committee on Cancer (AJCC) classification for liver neoplasm based on the imaging findings, we found significant differences between stages I/II and III (p < 0.001) and between stages III and IV (p = 0.040). We conclude CT or MRI can be used to identify the prognostic factors and to estimate the outcomes of patients with cHCC‐CC.</description><identifier>ISSN: 1368-5031</identifier><identifier>EISSN: 1742-1241</identifier><identifier>DOI: 10.1111/j.1742-1241.2007.01291.x</identifier><identifier>PMID: 17537192</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bile Duct Neoplasms - mortality ; Bile Duct Neoplasms - pathology ; Bile Ducts, Intrahepatic - pathology ; Biological and medical sciences ; Cancer ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Cholangiocarcinoma - mortality ; Cholangiocarcinoma - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Humans ; Liver diseases ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Lymphatic Metastasis ; Magnetic Resonance Imaging - standards ; Male ; Medical prognosis ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness ; Neoplasm Staging ; Neoplasms, Multiple Primary - mortality ; Neoplasms, Multiple Primary - pathology ; NMR ; Nuclear magnetic resonance ; Prognosis ; Survival Analysis ; Survival Rate ; Tomography ; Tomography, X-Ray Computed - standards ; Tumors</subject><ispartof>International journal of clinical practice (Esher), 2008-08, Vol.62 (8), p.1199-1205</ispartof><rights>2007 The Authors. Journal compilation © 2007 Blackwell Publishing Ltd</rights><rights>2008 INIST-CNRS</rights><rights>Journal compilation © 2008 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5611-37b6892d8c070aa943e019be61bfcd9527f175e982f57f2bc76fafd348e3b3953</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1742-1241.2007.01291.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1742-1241.2007.01291.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20519560$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17537192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, G.</creatorcontrib><creatorcontrib>Toh, C.-H.</creatorcontrib><creatorcontrib>Wu, R.-C.</creatorcontrib><creatorcontrib>Ko, S.-F.</creatorcontrib><creatorcontrib>Ng, S.-H.</creatorcontrib><creatorcontrib>Chou, W.-C.</creatorcontrib><creatorcontrib>Tseng, J.-H.</creatorcontrib><title>Combined hepatocellular cholangiocarcinoma: prognostic factors investigated by computed tomography/magnetic resonance imaging</title><title>International journal of clinical practice (Esher)</title><addtitle>Int J Clin Pract</addtitle><description>Summary
This study was designed to assess the clinical usefulness of imaging for predicting the prognosis of patients with combined hepatocellular cholangiocarcinoma (cHCC‐CC). Between 1999 and 2004, 30 patients with histopathologically proven cHCC‐CC underwent computed tomography (CT) or magnetic resonance imaging (MRI). The imaging data and survival were analysed. Univariate log‐rank analysis of imaging findings revealed that tumour necrosis, bile duct invasion, major vascular branch invasion, multiplicity, bilobar distribution, regional lymph node involvement, regional organ invasion, distant metastasis and ascites had adverse influences on overall survival. Multivariate Cox proportional hazard analysis demonstrated that major vascular branch invasion, regional organ invasion, nodal and distant metastases were independent prognostic factors that adversely affected overall survival rates. Overall cumulative survival rates at 1, 3 and 5 years were 53%, 26% and 12%, respectively. Analysing the survival of our patients by using clinical stages of the newly updated American Joint Committee on Cancer (AJCC) classification for liver neoplasm based on the imaging findings, we found significant differences between stages I/II and III (p < 0.001) and between stages III and IV (p = 0.040). We conclude CT or MRI can be used to identify the prognostic factors and to estimate the outcomes of patients with cHCC‐CC.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bile Duct Neoplasms - mortality</subject><subject>Bile Duct Neoplasms - pathology</subject><subject>Bile Ducts, Intrahepatic - pathology</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cholangiocarcinoma - mortality</subject><subject>Cholangiocarcinoma - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Humans</subject><subject>Liver diseases</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Lymphatic Metastasis</subject><subject>Magnetic Resonance Imaging - standards</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Multiple Primary - mortality</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Prognosis</subject><subject>Survival Analysis</subject><subject>Survival Rate</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed - standards</subject><subject>Tumors</subject><issn>1368-5031</issn><issn>1742-1241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEoqXwF1CEBLek_oi_OCChBZaiqvQA6tFyHCfrJbFTO4HdA_8dh10WiQu-eDR-_GremcmyHIISpnO5LSGrUAFRBUsEACsBRAKWuwfZ-enhYYox5QUBGJ5lT2LcAoAI4eBxdgYZwQwKdJ79XPmhts40-caMavLa9P3cq5Drje-V66zXKmjr_KBe52PwnfNxsjpvlZ58iLl1301KdGpKEvU-134Y5yWe_OC7oMbN_nJQnTPLp2Cid8ppk9uUs657mj1qVR_Ns-N9kX398P7L6mNx_Xl9tXp7XWhCISwwqykXqOEaMKCUqLABUNSGwrrVjSCItcmRERy1hLWo1oy2qm1wxQ2usSD4Int10E0O7udUsBxsXKwqZ_wcJU2SGHL6XxCKiiPMqwS--Afc-jm4ZEIiJERFcMUS9PwIzfVgGjmG5Dvs5Z_2J-DlEVBRq74NqTk2njgECBSEgsS9OXA_bG_2f3WAXNZBbuUydblMXS7rIH-vg9zJq0-r2yVMAsVBwMbJ7E4CKnyTlGFG5N3NWhJ-9-5mDbG8xb8ACae5lA</recordid><startdate>200808</startdate><enddate>200808</enddate><creator>Lin, G.</creator><creator>Toh, C.-H.</creator><creator>Wu, R.-C.</creator><creator>Ko, S.-F.</creator><creator>Ng, S.-H.</creator><creator>Chou, W.-C.</creator><creator>Tseng, J.-H.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Hindawi Limited</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200808</creationdate><title>Combined hepatocellular cholangiocarcinoma: prognostic factors investigated by computed tomography/magnetic resonance imaging</title><author>Lin, G. ; Toh, C.-H. ; Wu, R.-C. ; Ko, S.-F. ; Ng, S.-H. ; Chou, W.-C. ; Tseng, J.-H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5611-37b6892d8c070aa943e019be61bfcd9527f175e982f57f2bc76fafd348e3b3953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bile Duct Neoplasms - mortality</topic><topic>Bile Duct Neoplasms - pathology</topic><topic>Bile Ducts, Intrahepatic - pathology</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cholangiocarcinoma - mortality</topic><topic>Cholangiocarcinoma - pathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Humans</topic><topic>Liver diseases</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Lymphatic Metastasis</topic><topic>Magnetic Resonance Imaging - standards</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Multiple Primary - mortality</topic><topic>Neoplasms, Multiple Primary - pathology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Prognosis</topic><topic>Survival Analysis</topic><topic>Survival Rate</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed - standards</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, G.</creatorcontrib><creatorcontrib>Toh, C.-H.</creatorcontrib><creatorcontrib>Wu, R.-C.</creatorcontrib><creatorcontrib>Ko, S.-F.</creatorcontrib><creatorcontrib>Ng, S.-H.</creatorcontrib><creatorcontrib>Chou, W.-C.</creatorcontrib><creatorcontrib>Tseng, J.-H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical practice (Esher)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, G.</au><au>Toh, C.-H.</au><au>Wu, R.-C.</au><au>Ko, S.-F.</au><au>Ng, S.-H.</au><au>Chou, W.-C.</au><au>Tseng, J.-H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined hepatocellular cholangiocarcinoma: prognostic factors investigated by computed tomography/magnetic resonance imaging</atitle><jtitle>International journal of clinical practice (Esher)</jtitle><addtitle>Int J Clin Pract</addtitle><date>2008-08</date><risdate>2008</risdate><volume>62</volume><issue>8</issue><spage>1199</spage><epage>1205</epage><pages>1199-1205</pages><issn>1368-5031</issn><eissn>1742-1241</eissn><abstract>Summary
This study was designed to assess the clinical usefulness of imaging for predicting the prognosis of patients with combined hepatocellular cholangiocarcinoma (cHCC‐CC). Between 1999 and 2004, 30 patients with histopathologically proven cHCC‐CC underwent computed tomography (CT) or magnetic resonance imaging (MRI). The imaging data and survival were analysed. Univariate log‐rank analysis of imaging findings revealed that tumour necrosis, bile duct invasion, major vascular branch invasion, multiplicity, bilobar distribution, regional lymph node involvement, regional organ invasion, distant metastasis and ascites had adverse influences on overall survival. Multivariate Cox proportional hazard analysis demonstrated that major vascular branch invasion, regional organ invasion, nodal and distant metastases were independent prognostic factors that adversely affected overall survival rates. Overall cumulative survival rates at 1, 3 and 5 years were 53%, 26% and 12%, respectively. Analysing the survival of our patients by using clinical stages of the newly updated American Joint Committee on Cancer (AJCC) classification for liver neoplasm based on the imaging findings, we found significant differences between stages I/II and III (p < 0.001) and between stages III and IV (p = 0.040). We conclude CT or MRI can be used to identify the prognostic factors and to estimate the outcomes of patients with cHCC‐CC.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17537192</pmid><doi>10.1111/j.1742-1241.2007.01291.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Bile Duct Neoplasms - mortality Bile Duct Neoplasms - pathology Bile Ducts, Intrahepatic - pathology Biological and medical sciences Cancer Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Cholangiocarcinoma - mortality Cholangiocarcinoma - pathology Female Gastroenterology. Liver. Pancreas. Abdomen General aspects Humans Liver diseases Liver Neoplasms - mortality Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Lymphatic Metastasis Magnetic Resonance Imaging - standards Male Medical prognosis Medical sciences Middle Aged Multivariate Analysis Neoplasm Invasiveness Neoplasm Staging Neoplasms, Multiple Primary - mortality Neoplasms, Multiple Primary - pathology NMR Nuclear magnetic resonance Prognosis Survival Analysis Survival Rate Tomography Tomography, X-Ray Computed - standards Tumors |
| title | Combined hepatocellular cholangiocarcinoma: prognostic factors investigated by computed tomography/magnetic resonance imaging |
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