Ethyl pyruvate and ethyl lactate down-regulate the production of pro-inflammatory cytokines and modulate expression of immune receptors

Esters of α-oxo-carbonic acids such as ethyl pyruvate (EP) have been demonstrated to exert inhibitory effects on the production of anti-inflammatory cytokines. So far, there is no information about effects, if any, of ethyl lactate (EL), an obviously inactive analogue of EP, on inflammatory immune r...

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Veröffentlicht in:Biochemical pharmacology 2008-09, Vol.76 (5), p.631-644
Hauptverfasser: Hollenbach, Marcus, Hintersdorf, Anja, Huse, Klaus, Sack, Ulrich, Bigl, Marina, Groth, Marco, Santel, Thore, Buchold, Martin, Lindner, Inge, Otto, Andreas, Sicker, Dieter, Schellenberger, Wolfgang, Almendinger, Johannes, Pustowoit, Barbara, Birkemeyer, Claudia, Platzer, Mathias, Oerlecke, Ilka, Hemdan, Nasr, Birkenmeier, Gerd
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Sprache:eng
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