The use of aptamers in large arrays for molecular diagnostics

Aptamers are single-stranded oligonucleotides derived from an in vitro evolution protocol called systematic evolution of ligands by exponential enrichment (SELEX). They bind tightly and specifically to target molecules; most aptamers to proteins bind with K dS (equilibrium dissociation constant) in...

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Veröffentlicht in:	Molecular diagnosis 1999-12, Vol.4 (4), p.381-388
Hauptverfasser:	Brody, Edward N., Willis, Michael C., Smith, Jonathan D., Jayasena, Sumedha, Zichi, Dominic, Gold, Larry
Format:	Artikel
Sprache:	eng
Schlagworte:	Body Fluids - chemistry Bromodeoxyuridine Clinical Laboratory Techniques Combinatorial Chemistry Techniques Humans Idoxuridine Ligands Oligonucleotide Array Sequence Analysis photo-cross-linking Proteins - analysis proteomics systematic evolution of ligands by exponential enrichment (SELEX) universal protein stain
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