A pharmacokinetic model for multiple sites discontinuous gastrointestinal absorption

Purpose. To build a pharmacokinetic model taking into account a discontinous absorption along the gut, from n successive sites, a non-absorbing intestinal segment being always in between two successive sites. To solve the mathematical model linked with the pharmacokinetic model to obtain the concent...

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Veröffentlicht in:	Medical engineering & physics 1999-10, Vol.21 (8), p.525-532
Hauptverfasser:	Plusquellec, Yves, Efthymiopoulos, Constantin, Duthil, Pierre, Houin, Georges
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Administration, Oral Anti-Ulcer Agents - pharmacokinetics Area Under Curve Biological and medical sciences Biological Availability Delay Discontinuous absorption General pharmacology Humans Intestinal Absorption Laplace transform and inverse Laplace transforms Male Mathematical models Medical sciences Models, Biological Models, Theoretical Pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Ranitidine Ranitidine - administration & dosage Ranitidine - pharmacokinetics Secondary peaks
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