A comparative study on in vitro and in vivo effects of topical vasodilators in human internal mammary, radial artery and great saphenous vein
Objective: As an important prognostic factor of coronary artery bypass grafting (CABG), graft vasospasm can be observed in all currently used graft conduits. Radial artery (RA) vasospasm is more prone to occur in comparisons with internal mammary artery (IMA) and great saphenous vein (GSV). There is...
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| creator | Ding, Rongjing Feng, Wenhui Li, Hongwei Wang, Lei Li, Dalian Cheng, Zhiguang Guo, Jianzhong Hu, Dayi |
| description | Objective: As an important prognostic factor of coronary artery bypass grafting (CABG), graft vasospasm can be observed in all currently used graft conduits. Radial artery (RA) vasospasm is more prone to occur in comparisons with internal mammary artery (IMA) and great saphenous vein (GSV). There is still controversy about which antispasmodic agent is superior to different grafts, especially to RA conduits. The aim of this pilot study was to investigate the relaxation response of four topical vasodilators to different in vitro grafts and how these vasodilators affect the blood flow of the vessel in situ during RA harvesting. Materials and methods: Vasodilatory properties of diltiazem, nitroglycerin, urapidil and nicorandil were compared in matched patient-specific segments of RA, IMA and GSV harvested from 12 patients. The vasodilatory response of the RA to intraradial administration of nitroglycerin, diltiazem and urapidil was compared in vivo (n = 10 per group) by assessing the free blood flow of RA. Results: (1) The maximal relaxations occurring with urapidil, nitroglycerin and nicorandil in IMA, RA and SGV were significantly greater than that with diltiazem. The reactivity of all three graft conduits showed similar relaxation with nitroglycerin or with diltiazem, but the relaxation with urapidil in RA showed greater than that of IMA and GSV, and RA and GSV showed greater relaxation with nicorandil than IMA. (2) A dose of 10−5 mol/l of nitroglycerin, urapidil and nicorandil but not diltiazem significantly inhibited the RA response to PE. (3) In vivo, urapidil and nitroglycerin significantly increased the RA blood flow, the potency of which was greater than that caused by diltiazem. Conclusions: (1) Comparing with nicorandil, urapidil and diltiazem, nitroglycerin caused a significant relaxation in all three graft vessels tested. (2) Nitroglycerin, nicorandil and urapidil were more effective in preventing RA spasm than diltiazem. |
| doi_str_mv | 10.1016/j.ejcts.2008.05.050 |
| format | Article |
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Radial artery (RA) vasospasm is more prone to occur in comparisons with internal mammary artery (IMA) and great saphenous vein (GSV). There is still controversy about which antispasmodic agent is superior to different grafts, especially to RA conduits. The aim of this pilot study was to investigate the relaxation response of four topical vasodilators to different in vitro grafts and how these vasodilators affect the blood flow of the vessel in situ during RA harvesting. Materials and methods: Vasodilatory properties of diltiazem, nitroglycerin, urapidil and nicorandil were compared in matched patient-specific segments of RA, IMA and GSV harvested from 12 patients. The vasodilatory response of the RA to intraradial administration of nitroglycerin, diltiazem and urapidil was compared in vivo (n = 10 per group) by assessing the free blood flow of RA. Results: (1) The maximal relaxations occurring with urapidil, nitroglycerin and nicorandil in IMA, RA and SGV were significantly greater than that with diltiazem. The reactivity of all three graft conduits showed similar relaxation with nitroglycerin or with diltiazem, but the relaxation with urapidil in RA showed greater than that of IMA and GSV, and RA and GSV showed greater relaxation with nicorandil than IMA. (2) A dose of 10−5 mol/l of nitroglycerin, urapidil and nicorandil but not diltiazem significantly inhibited the RA response to PE. (3) In vivo, urapidil and nitroglycerin significantly increased the RA blood flow, the potency of which was greater than that caused by diltiazem. Conclusions: (1) Comparing with nicorandil, urapidil and diltiazem, nitroglycerin caused a significant relaxation in all three graft vessels tested. (2) Nitroglycerin, nicorandil and urapidil were more effective in preventing RA spasm than diltiazem.</description><identifier>ISSN: 1010-7940</identifier><identifier>EISSN: 1873-734X</identifier><identifier>DOI: 10.1016/j.ejcts.2008.05.050</identifier><identifier>PMID: 18632282</identifier><identifier>CODEN: EJCSE7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Science B.V</publisher><subject>Aged ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Cardiology. Vascular system ; Coronary artery bypass grafting ; Coronary heart disease ; Diltiazem ; Diltiazem - pharmacology ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Female ; Heart ; Heart Rate - drug effects ; Humans ; Male ; Mammary Arteries - drug effects ; Mammary Arteries - physiology ; Medical sciences ; Middle Aged ; Nicorandil ; Nicorandil - pharmacology ; Nitroglycerin ; Nitroglycerin - pharmacology ; Organ Culture Techniques ; Piperazines - pharmacology ; Pneumology ; Radial Artery - drug effects ; Radial Artery - physiology ; Saphenous Vein - drug effects ; Saphenous Vein - physiology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Urapidil ; Vasodilation - drug effects ; Vasodilator Agents - pharmacology ; Vasospasm</subject><ispartof>European journal of cardio-thoracic surgery, 2008-09, Vol.34 (3), p.536-541</ispartof><rights>European Association for Cardio-Thoracic Surgery © 2008 European Association for Cardio-Thoracic Surgery 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-78c8d0ce5279fadebf76e0f8cf1234ce7b39645bee77f6f6c4225c1a496efd3c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20674304$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18632282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ding, Rongjing</creatorcontrib><creatorcontrib>Feng, Wenhui</creatorcontrib><creatorcontrib>Li, Hongwei</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Li, Dalian</creatorcontrib><creatorcontrib>Cheng, Zhiguang</creatorcontrib><creatorcontrib>Guo, Jianzhong</creatorcontrib><creatorcontrib>Hu, Dayi</creatorcontrib><title>A comparative study on in vitro and in vivo effects of topical vasodilators in human internal mammary, radial artery and great saphenous vein</title><title>European journal of cardio-thoracic surgery</title><addtitle>Eur J Cardiothorac Surg</addtitle><addtitle>Eur J Cardiothorac Surg</addtitle><description>Objective: As an important prognostic factor of coronary artery bypass grafting (CABG), graft vasospasm can be observed in all currently used graft conduits. Radial artery (RA) vasospasm is more prone to occur in comparisons with internal mammary artery (IMA) and great saphenous vein (GSV). There is still controversy about which antispasmodic agent is superior to different grafts, especially to RA conduits. The aim of this pilot study was to investigate the relaxation response of four topical vasodilators to different in vitro grafts and how these vasodilators affect the blood flow of the vessel in situ during RA harvesting. Materials and methods: Vasodilatory properties of diltiazem, nitroglycerin, urapidil and nicorandil were compared in matched patient-specific segments of RA, IMA and GSV harvested from 12 patients. The vasodilatory response of the RA to intraradial administration of nitroglycerin, diltiazem and urapidil was compared in vivo (n = 10 per group) by assessing the free blood flow of RA. Results: (1) The maximal relaxations occurring with urapidil, nitroglycerin and nicorandil in IMA, RA and SGV were significantly greater than that with diltiazem. The reactivity of all three graft conduits showed similar relaxation with nitroglycerin or with diltiazem, but the relaxation with urapidil in RA showed greater than that of IMA and GSV, and RA and GSV showed greater relaxation with nicorandil than IMA. (2) A dose of 10−5 mol/l of nitroglycerin, urapidil and nicorandil but not diltiazem significantly inhibited the RA response to PE. (3) In vivo, urapidil and nitroglycerin significantly increased the RA blood flow, the potency of which was greater than that caused by diltiazem. Conclusions: (1) Comparing with nicorandil, urapidil and diltiazem, nitroglycerin caused a significant relaxation in all three graft vessels tested. (2) Nitroglycerin, nicorandil and urapidil were more effective in preventing RA spasm than diltiazem.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiology. Vascular system</subject><subject>Coronary artery bypass grafting</subject><subject>Coronary heart disease</subject><subject>Diltiazem</subject><subject>Diltiazem - pharmacology</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Female</subject><subject>Heart</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Mammary Arteries - drug effects</subject><subject>Mammary Arteries - physiology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nicorandil</subject><subject>Nicorandil - pharmacology</subject><subject>Nitroglycerin</subject><subject>Nitroglycerin - pharmacology</subject><subject>Organ Culture Techniques</subject><subject>Piperazines - pharmacology</subject><subject>Pneumology</subject><subject>Radial Artery - drug effects</subject><subject>Radial Artery - physiology</subject><subject>Saphenous Vein - drug effects</subject><subject>Saphenous Vein - physiology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Urapidil</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vasospasm</subject><issn>1010-7940</issn><issn>1873-734X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAQxyMEoqXwBEjIFzg1wV-xk2OpKEVaxAVE1YvldcbUyyZObSdiH4J3xmlW5Yo0kmc0v__MeKYoXhNcEUzE-10FO5NiRTFuKlxnw0-KU9JIVkrGb55mHxNcypbjk-JFjDuMsWBUPi9OSJMd2tDT4s8FMr4fddDJzYBimroD8gNyA5pdCh7poVuD2SOwFnJH5C1KfnRG79Gso-_cXicf4sLdTb1e1AnCkNO97nsdDuco6M7lWIecODwU_RlAJxT1eAeDnyKawQ0vi2dW7yO8Or5nxferj98ur8vN10-fLy82peG8TqVsTNNhAzWVrdUdbK0UgG1jLKGMG5Bb1gpebwGktMIKwymtDdG8FWA7ZthZ8W6tOwZ_P0FMqnfRwH6vB8izKNFyRlraZpCtoAk-xgBWjcEtP1IEq-UKaqcerqCWKyhcZ8NZ9eZYftr20P3THNeegbdHQMe8RRv0YFx85CgWkjPMM1etnJ_G_-xcrgIXE_x-lOjwSwnJZK2ub24VEZsf8sPtF0XYX0cWs0c</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Ding, Rongjing</creator><creator>Feng, Wenhui</creator><creator>Li, Hongwei</creator><creator>Wang, Lei</creator><creator>Li, Dalian</creator><creator>Cheng, Zhiguang</creator><creator>Guo, Jianzhong</creator><creator>Hu, Dayi</creator><general>Elsevier Science B.V</general><general>Elsevier Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080901</creationdate><title>A comparative study on in vitro and in vivo effects of topical vasodilators in human internal mammary, radial artery and great saphenous vein</title><author>Ding, Rongjing ; Feng, Wenhui ; Li, Hongwei ; Wang, Lei ; Li, Dalian ; Cheng, Zhiguang ; Guo, Jianzhong ; Hu, Dayi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-78c8d0ce5279fadebf76e0f8cf1234ce7b39645bee77f6f6c4225c1a496efd3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiology. Vascular system</topic><topic>Coronary artery bypass grafting</topic><topic>Coronary heart disease</topic><topic>Diltiazem</topic><topic>Diltiazem - pharmacology</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Female</topic><topic>Heart</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Mammary Arteries - drug effects</topic><topic>Mammary Arteries - physiology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nicorandil</topic><topic>Nicorandil - pharmacology</topic><topic>Nitroglycerin</topic><topic>Nitroglycerin - pharmacology</topic><topic>Organ Culture Techniques</topic><topic>Piperazines - pharmacology</topic><topic>Pneumology</topic><topic>Radial Artery - drug effects</topic><topic>Radial Artery - physiology</topic><topic>Saphenous Vein - drug effects</topic><topic>Saphenous Vein - physiology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Urapidil</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vasospasm</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ding, Rongjing</creatorcontrib><creatorcontrib>Feng, Wenhui</creatorcontrib><creatorcontrib>Li, Hongwei</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Li, Dalian</creatorcontrib><creatorcontrib>Cheng, Zhiguang</creatorcontrib><creatorcontrib>Guo, Jianzhong</creatorcontrib><creatorcontrib>Hu, Dayi</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cardio-thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ding, Rongjing</au><au>Feng, Wenhui</au><au>Li, Hongwei</au><au>Wang, Lei</au><au>Li, Dalian</au><au>Cheng, Zhiguang</au><au>Guo, Jianzhong</au><au>Hu, Dayi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative study on in vitro and in vivo effects of topical vasodilators in human internal mammary, radial artery and great saphenous vein</atitle><jtitle>European journal of cardio-thoracic surgery</jtitle><stitle>Eur J Cardiothorac Surg</stitle><addtitle>Eur J Cardiothorac Surg</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>34</volume><issue>3</issue><spage>536</spage><epage>541</epage><pages>536-541</pages><issn>1010-7940</issn><eissn>1873-734X</eissn><coden>EJCSE7</coden><abstract>Objective: As an important prognostic factor of coronary artery bypass grafting (CABG), graft vasospasm can be observed in all currently used graft conduits. Radial artery (RA) vasospasm is more prone to occur in comparisons with internal mammary artery (IMA) and great saphenous vein (GSV). There is still controversy about which antispasmodic agent is superior to different grafts, especially to RA conduits. The aim of this pilot study was to investigate the relaxation response of four topical vasodilators to different in vitro grafts and how these vasodilators affect the blood flow of the vessel in situ during RA harvesting. Materials and methods: Vasodilatory properties of diltiazem, nitroglycerin, urapidil and nicorandil were compared in matched patient-specific segments of RA, IMA and GSV harvested from 12 patients. The vasodilatory response of the RA to intraradial administration of nitroglycerin, diltiazem and urapidil was compared in vivo (n = 10 per group) by assessing the free blood flow of RA. Results: (1) The maximal relaxations occurring with urapidil, nitroglycerin and nicorandil in IMA, RA and SGV were significantly greater than that with diltiazem. The reactivity of all three graft conduits showed similar relaxation with nitroglycerin or with diltiazem, but the relaxation with urapidil in RA showed greater than that of IMA and GSV, and RA and GSV showed greater relaxation with nicorandil than IMA. (2) A dose of 10−5 mol/l of nitroglycerin, urapidil and nicorandil but not diltiazem significantly inhibited the RA response to PE. (3) In vivo, urapidil and nitroglycerin significantly increased the RA blood flow, the potency of which was greater than that caused by diltiazem. Conclusions: (1) Comparing with nicorandil, urapidil and diltiazem, nitroglycerin caused a significant relaxation in all three graft vessels tested. (2) Nitroglycerin, nicorandil and urapidil were more effective in preventing RA spasm than diltiazem.</abstract><cop>Amsterdam</cop><pub>Elsevier Science B.V</pub><pmid>18632282</pmid><doi>10.1016/j.ejcts.2008.05.050</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Coronary artery bypass grafting Coronary heart disease Diltiazem Diltiazem - pharmacology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Heart Heart Rate - drug effects Humans Male Mammary Arteries - drug effects Mammary Arteries - physiology Medical sciences Middle Aged Nicorandil Nicorandil - pharmacology Nitroglycerin Nitroglycerin - pharmacology Organ Culture Techniques Piperazines - pharmacology Pneumology Radial Artery - drug effects Radial Artery - physiology Saphenous Vein - drug effects Saphenous Vein - physiology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Urapidil Vasodilation - drug effects Vasodilator Agents - pharmacology Vasospasm |
| title | A comparative study on in vitro and in vivo effects of topical vasodilators in human internal mammary, radial artery and great saphenous vein |
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