Experimental study on vasoactive intestinal peptide (VIP) and its diaminopropane bound (VIP-DAP) analog in solution

Bioactive peptides represent an exciting area of research in the fields of biochemistry and medicine and in particular the VIP/PACAP network appears to be of interest. Vasoactive intestinal peptide (VIP) is a pleiotropic factor that exerts a physiological regulatory influence and is involved in the...

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Veröffentlicht in:Amino acids 2008-08, Vol.35 (2), p.275-281
Hauptverfasser: Caraglia, M, Carteni, M, Dicitore, A, Cassese, D, De Maria, S, Ferranti, P, Giuberti, G, Abbruzzese, A, Stiuso, P
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container_end_page 281
container_issue 2
container_start_page 275
container_title Amino acids
container_volume 35
creator Caraglia, M
Carteni, M
Dicitore, A
Cassese, D
De Maria, S
Ferranti, P
Giuberti, G
Abbruzzese, A
Stiuso, P
description Bioactive peptides represent an exciting area of research in the fields of biochemistry and medicine and in particular the VIP/PACAP network appears to be of interest. Vasoactive intestinal peptide (VIP) is a pleiotropic factor that exerts a physiological regulatory influence and is involved in the pathogenesis of several human disorders. In this paper we have reported structural characterization of VIP by experimental and computational methods as well as a comparative analysis of the peptide with its transglutaminase catalyzed analog VIP-Diaminopropane (VIP-DAP).
doi_str_mv 10.1007/s00726-007-0567-3
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subjects Amino acids
Analytical Chemistry
Animals
Biochemical Engineering
Biochemistry
Biomedical and Life Sciences
Comparative analysis
Computational study
Diamines - chemistry
Disorders
Human
Humans
Life Sciences
Limited proteolysis
Mathematical models
Models, Molecular
Networks
Neurobiology
Pathogenesis
Peptides
Proteomics
Review Article
Solutions - chemistry
Studies
Time Factors
Transglutaminase (TGase)
Vasoactive intestinal peptide (VIP)
Vasoactive Intestinal Peptide - chemistry
VPAC receptors
title Experimental study on vasoactive intestinal peptide (VIP) and its diaminopropane bound (VIP-DAP) analog in solution
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