The effects of dexamethasone on the response of bronchus-associated lymphoid tissue to intranasal administration of formalin-killed Pasteurella haemolytica A2 in goats
A trial was conducted to observe the immediate and chronic effects in goats of dexamethasone administration on the bronchus-associated lymphoid tissue (BALT) response to intranasal administration of formalin-killed Pasteurella haemolytica A2. Twenty-four goats were divided into four groups. Those in...
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| Veröffentlicht in: | Veterinary research communications 1999-12, Vol.23 (8), p.467-473 |
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| creator | Zamri-Saad, M. (Universiti Putra Malaysia, Serdan ,Selangor (Malaysia). Faculty of Veterinary Medicine) Effendy, A.W.M |
| description | A trial was conducted to observe the immediate and chronic effects in goats of dexamethasone administration on the bronchus-associated lymphoid tissue (BALT) response to intranasal administration of formalin-killed Pasteurella haemolytica A2. Twenty-four goats were divided into four groups. Those in group 1 were injected intramuscularly with 1 mg/kg dexamethasone on three consecutive days, followed by intranasal exposure to formalin-killed P. haemolytica A2 one day after the last dexamethasone treatment. The goats in group 2 were similarly injected with dexamethasone followed by intranasal exposure to formalin-killed P. haemolytica A2 21 days after the last dexamethasone treatment. The animals in group 3 were exposed intranasally to formalin-killed P. haemolytica A2 without prior dexamethasone treatment. The animals in group 4 were untreated controls. The intranasal exposures to formalin-killed P. haemolytica A2 were repeated 2 weeks later. Intranasal exposure to formalin-killed P. haemolytica 1 day after dexamethasone treatment further reduced the number and size of BALT compared to the untreated control. Significantly (p < 0.01) more reduction of BALT occurred in goats exposed to formalin-killed P. haemolytica A2 21 days after dexamethasone treatment. On the other hand, intranasal exposure of goats without prior dexamethasone treatment stimulated the BALT compared to the untreated controls. |
| doi_str_mv | 10.1023/A:1006371821128 |
| format | Article |
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(Universiti Putra Malaysia, Serdan ,Selangor (Malaysia). Faculty of Veterinary Medicine) ; Effendy, A.W.M</creator><creatorcontrib>Zamri-Saad, M. (Universiti Putra Malaysia, Serdan ,Selangor (Malaysia). Faculty of Veterinary Medicine) ; Effendy, A.W.M</creatorcontrib><description>A trial was conducted to observe the immediate and chronic effects in goats of dexamethasone administration on the bronchus-associated lymphoid tissue (BALT) response to intranasal administration of formalin-killed Pasteurella haemolytica A2. Twenty-four goats were divided into four groups. Those in group 1 were injected intramuscularly with 1 mg/kg dexamethasone on three consecutive days, followed by intranasal exposure to formalin-killed P. haemolytica A2 one day after the last dexamethasone treatment. The goats in group 2 were similarly injected with dexamethasone followed by intranasal exposure to formalin-killed P. haemolytica A2 21 days after the last dexamethasone treatment. The animals in group 3 were exposed intranasally to formalin-killed P. haemolytica A2 without prior dexamethasone treatment. The animals in group 4 were untreated controls. The intranasal exposures to formalin-killed P. haemolytica A2 were repeated 2 weeks later. Intranasal exposure to formalin-killed P. haemolytica 1 day after dexamethasone treatment further reduced the number and size of BALT compared to the untreated control. Significantly (p < 0.01) more reduction of BALT occurred in goats exposed to formalin-killed P. haemolytica A2 21 days after dexamethasone treatment. On the other hand, intranasal exposure of goats without prior dexamethasone treatment stimulated the BALT compared to the untreated controls.</description><identifier>ISSN: 0165-7380</identifier><identifier>EISSN: 1573-7446</identifier><identifier>DOI: 10.1023/A:1006371821128</identifier><identifier>PMID: 10672963</identifier><language>eng</language><publisher>Netherlands: Springer Nature B.V</publisher><subject>Administration, Intranasal ; ANIMAL TISSUES ; Animals ; Anti-Inflammatory Agents - pharmacology ; BRONCHE ; BRONCHI ; Bronchi - drug effects ; Bronchi - immunology ; Bronchi - microbiology ; BRONQUIOS ; CAPRIN ; CAPRINOS ; DEXAMETASONA ; DEXAMETHASONE ; Dexamethasone - pharmacology ; FORMALDEHIDO ; FORMALDEHYDE ; Goat Diseases - immunology ; GOATS ; LINFOCITOS ; LYMPHATIC SYSTEM ; LYMPHOCYTE ; LYMPHOCYTES ; Lymphoid Tissue - drug effects ; Lymphoid Tissue - immunology ; Lymphoid Tissue - microbiology ; Mannheimia haemolytica - immunology ; PASTEURELLA HAEMOLYTICA ; Pasteurellosis, Pneumonic - immunology ; Random Allocation ; SISTEMA LINFATICO ; SYSTEME LYMPHATIQUE ; TEJIDOS ANIMALES ; TISSU ANIMAL</subject><ispartof>Veterinary research communications, 1999-12, Vol.23 (8), p.467-473</ispartof><rights>Copyright (c) 1999 Kluwer Academic Publishers</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c302t-7e8f42253f3bae3e3cd5cf8aeca9bd2d6c2a379f2594ef69eaac51836070b6b73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10672963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zamri-Saad, M. (Universiti Putra Malaysia, Serdan ,Selangor (Malaysia). Faculty of Veterinary Medicine)</creatorcontrib><creatorcontrib>Effendy, A.W.M</creatorcontrib><title>The effects of dexamethasone on the response of bronchus-associated lymphoid tissue to intranasal administration of formalin-killed Pasteurella haemolytica A2 in goats</title><title>Veterinary research communications</title><addtitle>Vet Res Commun</addtitle><description>A trial was conducted to observe the immediate and chronic effects in goats of dexamethasone administration on the bronchus-associated lymphoid tissue (BALT) response to intranasal administration of formalin-killed Pasteurella haemolytica A2. Twenty-four goats were divided into four groups. Those in group 1 were injected intramuscularly with 1 mg/kg dexamethasone on three consecutive days, followed by intranasal exposure to formalin-killed P. haemolytica A2 one day after the last dexamethasone treatment. The goats in group 2 were similarly injected with dexamethasone followed by intranasal exposure to formalin-killed P. haemolytica A2 21 days after the last dexamethasone treatment. The animals in group 3 were exposed intranasally to formalin-killed P. haemolytica A2 without prior dexamethasone treatment. The animals in group 4 were untreated controls. The intranasal exposures to formalin-killed P. haemolytica A2 were repeated 2 weeks later. Intranasal exposure to formalin-killed P. haemolytica 1 day after dexamethasone treatment further reduced the number and size of BALT compared to the untreated control. Significantly (p < 0.01) more reduction of BALT occurred in goats exposed to formalin-killed P. haemolytica A2 21 days after dexamethasone treatment. On the other hand, intranasal exposure of goats without prior dexamethasone treatment stimulated the BALT compared to the untreated controls.</description><subject>Administration, Intranasal</subject><subject>ANIMAL TISSUES</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>BRONCHE</subject><subject>BRONCHI</subject><subject>Bronchi - drug effects</subject><subject>Bronchi - immunology</subject><subject>Bronchi - microbiology</subject><subject>BRONQUIOS</subject><subject>CAPRIN</subject><subject>CAPRINOS</subject><subject>DEXAMETASONA</subject><subject>DEXAMETHASONE</subject><subject>Dexamethasone - pharmacology</subject><subject>FORMALDEHIDO</subject><subject>FORMALDEHYDE</subject><subject>Goat Diseases - immunology</subject><subject>GOATS</subject><subject>LINFOCITOS</subject><subject>LYMPHATIC SYSTEM</subject><subject>LYMPHOCYTE</subject><subject>LYMPHOCYTES</subject><subject>Lymphoid Tissue - drug effects</subject><subject>Lymphoid Tissue - immunology</subject><subject>Lymphoid Tissue - microbiology</subject><subject>Mannheimia haemolytica - immunology</subject><subject>PASTEURELLA HAEMOLYTICA</subject><subject>Pasteurellosis, Pneumonic - immunology</subject><subject>Random Allocation</subject><subject>SISTEMA LINFATICO</subject><subject>SYSTEME LYMPHATIQUE</subject><subject>TEJIDOS ANIMALES</subject><subject>TISSU ANIMAL</subject><issn>0165-7380</issn><issn>1573-7446</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkE1v1DAQhiMEokvhzAlkceAW8EdiJ9xWFV_SCjiUczRxxo1LYi8eR-r-Iv4mXrVcmMtoNM88ejVV9VLwd4JL9X7_QXCulRGdFEJ2j6qdaI2qTdPox9WOC93WRnX8onpGdMs57zuunlYXgmsje6121Z_rGRk6hzYTi45NeAcr5hkoBmQxsFz2CekYA-EZGFMMdt6oBqJoPWSc2HJaj3P0E8ueaEOWI_MhJwhAsDCYVh88lTn7IiwOF9MKiw_1L78s5f4HUMYt4bIAmwHXuJyyt8D2snjYTYRMz6snDhbCFw_9svr56eP11Zf68P3z16v9obaKy1wb7FwjZaucGgEVKju11nWAFvpxkpO2EpTpnWz7Bp3uEcC2olOaGz7q0ajL6u2995ji7w0pD6sne04WMG406L5RQitVwDf_gbdxS6FkG6Rpet01UhTo9QO0jStOwzH5FdJp-Pf_Ary6BxzEAW6Sp-HbQfJzSdMb9RfVIJR3</recordid><startdate>19991201</startdate><enddate>19991201</enddate><creator>Zamri-Saad, M. 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(Universiti Putra Malaysia, Serdan ,Selangor (Malaysia). Faculty of Veterinary Medicine)</au><au>Effendy, A.W.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of dexamethasone on the response of bronchus-associated lymphoid tissue to intranasal administration of formalin-killed Pasteurella haemolytica A2 in goats</atitle><jtitle>Veterinary research communications</jtitle><addtitle>Vet Res Commun</addtitle><date>1999-12-01</date><risdate>1999</risdate><volume>23</volume><issue>8</issue><spage>467</spage><epage>473</epage><pages>467-473</pages><issn>0165-7380</issn><eissn>1573-7446</eissn><abstract>A trial was conducted to observe the immediate and chronic effects in goats of dexamethasone administration on the bronchus-associated lymphoid tissue (BALT) response to intranasal administration of formalin-killed Pasteurella haemolytica A2. Twenty-four goats were divided into four groups. Those in group 1 were injected intramuscularly with 1 mg/kg dexamethasone on three consecutive days, followed by intranasal exposure to formalin-killed P. haemolytica A2 one day after the last dexamethasone treatment. The goats in group 2 were similarly injected with dexamethasone followed by intranasal exposure to formalin-killed P. haemolytica A2 21 days after the last dexamethasone treatment. The animals in group 3 were exposed intranasally to formalin-killed P. haemolytica A2 without prior dexamethasone treatment. The animals in group 4 were untreated controls. The intranasal exposures to formalin-killed P. haemolytica A2 were repeated 2 weeks later. Intranasal exposure to formalin-killed P. haemolytica 1 day after dexamethasone treatment further reduced the number and size of BALT compared to the untreated control. Significantly (p < 0.01) more reduction of BALT occurred in goats exposed to formalin-killed P. haemolytica A2 21 days after dexamethasone treatment. On the other hand, intranasal exposure of goats without prior dexamethasone treatment stimulated the BALT compared to the untreated controls.</abstract><cop>Netherlands</cop><pub>Springer Nature B.V</pub><pmid>10672963</pmid><doi>10.1023/A:1006371821128</doi><tpages>7</tpages></addata></record> |
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| ispartof | Veterinary research communications, 1999-12, Vol.23 (8), p.467-473 |
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| subjects | Administration, Intranasal ANIMAL TISSUES Animals Anti-Inflammatory Agents - pharmacology BRONCHE BRONCHI Bronchi - drug effects Bronchi - immunology Bronchi - microbiology BRONQUIOS CAPRIN CAPRINOS DEXAMETASONA DEXAMETHASONE Dexamethasone - pharmacology FORMALDEHIDO FORMALDEHYDE Goat Diseases - immunology GOATS LINFOCITOS LYMPHATIC SYSTEM LYMPHOCYTE LYMPHOCYTES Lymphoid Tissue - drug effects Lymphoid Tissue - immunology Lymphoid Tissue - microbiology Mannheimia haemolytica - immunology PASTEURELLA HAEMOLYTICA Pasteurellosis, Pneumonic - immunology Random Allocation SISTEMA LINFATICO SYSTEME LYMPHATIQUE TEJIDOS ANIMALES TISSU ANIMAL |
| title | The effects of dexamethasone on the response of bronchus-associated lymphoid tissue to intranasal administration of formalin-killed Pasteurella haemolytica A2 in goats |
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